Pd-catalyzed vinyl C–H amination with diaziridinone

Abstract

3-Amino-N-(quinolin-8-yl)acrylamides are obtained with up to 78% yield via Pd-catalyzed vinyl C–H amination with di-tert-butyldiaziridinone as a nitrogen source.

Palladium-Catalyzed anti-Michael-Type (Hetero)arylation of Acrylamides

“…To gain more insight into the reaction mechanism, a cinnamamide with a deuterium atom at the β-position was subjected to the reaction conditions. The results revealed a subtle reduction in deuteration, implying that C–H activation does not represent the predominant pathway in the anti -Michael-type addition reaction − (Scheme C). Next, the removal of the directing group was examined.…”