Pd(II) and Pt(II) complexes with aromatic diamines: study of their interaction with DNA

Linear free energy relationship for 4-substituted (o-phenylenediamine)platinum(II) dichloride derivatives using quantum mechanical descriptors

“…However, these angles are very close to those calculated for cis-dichloro(ethane-1,2-diamine)platinum(II) in our previous work [19]. These results indicate a reasonable structure when there is a bifunctional ligand attached to the Pt atom instead two amines [33,39]. The Pt-Cl and Pt-N bond lengths were found to be close to 2.1 and 2.4 Å , respectively.…”

“…The IC 50 values of two other o-phdPt derivatives were tested for in vitro growth inhibitory activity on three human cancer cell lines and the results were very promising since show basically the same effectiveness found for [Pt(en)Cl 2 ] and cisplatin in the breast cancer cell lines. More recently [33] distinct aromatic diamines have been used as ligand in the synthesis of new Pt(II) and Pd(II) complexes and their antitumour activity tested. The results show a promising biological activity when compared to cisplatin itself.…”

Palladium(II) and platinum(II) complexes containing benzimidazole ligands: Molecular structures, vibrational frequencies and cytotoxicity

“…The high toxicity of Pd-L 1,2 complex than Pt-L 2 happens because the ligand-exchange behavior of platinum compound is quite slow, which gives them a high kinetic stability and results in ligand-exchange reactions within minutes to days, rather than microseconds to seconds for many other coordination compounds. In addition, another unusual phenomenon deals with the preferred ligands for platinum ions is that Pt(II) has a strong thermodynamic preference for binding to S-donor ligands and for this reason, one would predict that platinum compounds would perhaps never reach DNA, with many cellular platinophiles (S-donor ligands, such as glutathione, methionine) as competing ligands in the cytosol [65]. In addition, Pt-L 1 complex shows the same cyctotoxic activity against the MCF-7 and Hep-G2 cell lines and twice that found against HCT cells.…”

Novel Pd(II) and Pt(II) complexes of N,N-donor benzimidazole ligand: Synthesis, spectral, electrochemical, DFT studies and evaluation of biological activity

“…This happens because the ligand-exchange behavior of platinum compounds is quite slow, which gives them a high kinetic stability and results in ligand-exchange reactions of minutes to days, rather than microseconds to seconds for many other coordination compounds. In addition, another unusual phenomenon deals with the preferred ligands for platinum ions is that Pt(II) has a strong thermodynamic preference for binding to Sdonor ligands and for this reason, one would predict that platinum compounds would perhaps never reach DNA, with many cellular platinophiles (S-donor ligands, such as glutathione, methionine) as competing ligands in the cytosol [55]. These complexes show higher activity at 100 lM against Hep-G2 cells in comparable with cis-platin and nearly the same activity against the other cells.…”