Pd(II) complexes with chelating N-(1-alkylpyridin-4(1H)-ylidene)amide (PYA) ligands: Synthesis, characterization and evaluation of anticancer activity

Zafar, Muhammad; Butt, Abdul Mannan; Chaudhry, Gul-e-Saba; Perveen, Fouzia; Nazar, Muhammad Faizan; Masood, Sara; Dalebrook, Andrew F.; Mughal, Ehsan Ullah; Sumrra, Sajjad Hussain; Sung, Yeong Yik; Muhammad, Tengku Sifzizul Tengku; Wright, L. James

doi:10.1016/j.jinorgbio.2021.111590

Cited by 20 publications

(9 citation statements)

References 54 publications

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“…With respect to other palladium(II) complexes reported, some of them have better biological results than ours at the same incubation times [ 28 , 30 , 32 ]. In contrast, our results improved some of the IC 50 values achieved with other palladium(II) compounds, thereby decreasing the concentration of some of them at the same incubation times, and even having lower IC 50 at shorter incubation times (24 h) [ 29 , 31 , 32 ]. Moreover, compared to closer structures to the ones presented in this work, we were not able to improve the biological activity of a complex previously synthesized by our lab (PdTdTn) on the U937 cell line [ 13 ].…”

Section: Resultsmentioning

confidence: 55%

“…The IC 50 values found for these two complexes were between 46.39 ± 3.99 μM and 62.74 ± 6.45 μM in the three lines, with no existing strong differences between the complexes or the cell lines ( Figure 2 A–C and Table 5 ). As reported in previous publications, other palladium(II) complexes have been studied on tumor cells, but in general with longer incubation times (48–72 h) [ 28 , 29 , 30 , 31 , 32 ]. To properly compare our findings with the literature, the cytotoxicity assay was also performed at 48 and 72 h in HeLa cells.…”

Section: Resultsmentioning

confidence: 99%

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Cytotoxic Effects of New Palladium(II) Complexes with Thiazine or Thiazoline Derivative Ligands in Tumor Cell Lines

et al. 2023

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The synthesis of analogs of cisplatin, which is a widely used chemotherapeutic agent, using other metal centers could be an alternative for cancer treatment. Pd(II) could be a substitute for Pt(II) due to its coordination chemistry similarity. For that reason, six squared-planar Pd(II) complexes with thiazine and thiazoline ligands and formula [PdCl2(L)] were synthesized and characterized in this work. The potential anticarcinogenic ability of the compounds was studied via cytotoxicity assay in three different human tumor cell lines, i.e., epithelial cervix carcinoma (HeLa), promyelocytic leukemia (HL-60), and histiocytic lymphoma (U-937). Data obtained showed that complexes with methyl substitutions did not modify cell viability, while no-methyl substituted compounds had a moderate cytotoxic effect on all three cell lines. The complexes with phenyl substitutions displayed the lowest IC50 values, which ranged between 46.39 ± 3.99 μM and 62.74 ± 6.45 μM. Moreover, Pd accumulation inside the cell was observed after incubation with any of the four complexes mentioned, and the two complexes with phenyl rings were found to induce an increase in the percentage of apoptotic cells. These results suggested that the presence of bulky substitutions on the ligands such as phenyl groups may influence the cytotoxicity of the chemotherapeutic agents synthesized.

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Section: Resultsmentioning

confidence: 55%

Section: Resultsmentioning

confidence: 99%

Cytotoxic Effects of New Palladium(II) Complexes with Thiazine or Thiazoline Derivative Ligands in Tumor Cell Lines

et al. 2023

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“…After treatment, cell viability was assessed by introducing 20 μl of fresh MTS solution into each well, allowing them to incubate for three hours, and then measuring the absorbance at 490 nm. 14,35…”

Section: Methodsmentioning

confidence: 99%

“…The known methylated and new benzylated meta pincer-PYA pro-ligands (H 2 L m Me (OTf) 2 and H 2 L m Bn (Cl) 2 were synthesized according to previously reported protocols. 12,29,35 Complexation to zinc and cadmium (C1-C4) was achieved by reacting the pro-ligands with the corresponding metal salts (Zn(OTf) 2 , Cd(CH 3 COO) 2 ) in the presence of DBU as a nonnucleophilic base (Scheme 1). 35 Complexation under these reaction conditions consistently afforded moderate yield.…”

Section: Synthesis and Characterization Of The Compoundsmentioning

confidence: 99%

Zn(ii) and Cd(ii) pincer complexes bearing meta alkylated pyridinium amidates; synthesis & preliminary anticancer studies

Masood,

Babar,

Chaudhry

et al. 2023

New J. Chem.

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“…Earlier studies demonstrated that Pd(II) complexes showed strong anticancer activity against different types of tumor cells (18)(19)(20). Studies have also revealed that Pd(II) complexes exhibited a strong cytotoxic effect by inducing apoptosis (18,21,22).…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Palladium(II) Complexes on DU-145 Cell Line in Vitro

Simić

Zarić

Jakovljevic

et al. 2022

Serbian Journal of Experimental and Clinical Research

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In the area of non-platinum complexes, various complexes containing gold, copper, ruthenium, and palladium have shown a strong cytotoxic effect on different cancer cell lines. The aim of our study was to examine the cytotoxicity of the Pd(II) complexes (C1-C5) and the corresponding ligands (L1-L5) on the DU-145 prostate cancer cell line. Also, due to its clinical application, the cytotoxicity of cisplatin has been examined. Our findings showed that C1- C5 complexes and cisplatin show dose-dependent and strong cytotoxic effects against the DU-145 cell line in vitro. Furthermore, the results demonstrated that early apoptosis was induced by all five Pd(II) complexes. Also, the results showed that complexes C1, C3, and C5 induced G0/G1 phase arrest on DU- 145 cells. Pd(II) complex C2 induced S phase arrest, while C4 complex induced G2/M phase arrest on cancer cells. Additionally, all tested complexes significantly reduced the amount of antiapoptotic protein Bcl-2. Also, there was a significant increase in the concentration of proapoptotic Bax protein in DU-145 cells treated C1-C5 complexes. The results of our research demonstrated that Pd(II) complexes induced apoptosis via the mitochondrial pathway. Thus, it is crucial to further investigate the cytotoxicity of these Pd(II) complexes in vivo. Complex C2 might be a good candidate for a new generation of anticancer drugs.

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Pd(II) complexes with chelating N-(1-alkylpyridin-4(1H)-ylidene)amide (PYA) ligands: Synthesis, characterization and evaluation of anticancer activity

Cited by 20 publications

References 54 publications

Cytotoxic Effects of New Palladium(II) Complexes with Thiazine or Thiazoline Derivative Ligands in Tumor Cell Lines

Cytotoxic Effects of New Palladium(II) Complexes with Thiazine or Thiazoline Derivative Ligands in Tumor Cell Lines

Zn(ii) and Cd(ii) pincer complexes bearing meta alkylated pyridinium amidates; synthesis & preliminary anticancer studies

Antitumor Activity of Palladium(II) Complexes on DU-145 Cell Line in Vitro

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