PD-L1 and PD-1 in immune regulation and their implications in blood cancers

Shiri Aghbash, Parisa; Mehdizadeh, Faezeh; Pourbeiragh, Ghazal; Yazdani, Yalda; Bannazadeh Baghi, Hossein; Jafari Sales, Abolfazl; Pashazadeh, Mehrdad; Kangari, Parisa

doi:10.1016/j.adcanc.2024.100125

Advances in Cancer Biology - Metastasis

2024

DOI: 10.1016/j.adcanc.2024.100125

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PD-L1 and PD-1 in immune regulation and their implications in blood cancers

Parisa Shiri Aghbash,

Faezeh Mehdizadeh,

Ghazal Pourbeiragh

et al.

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2024

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Role of Proteins in Oncology: Advances in Cancer Diagnosis, Prognosis, and Targeted Therapy—A Narrative Review

Kędzierska,

Bańkosz

2024

JCM

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Modern oncology increasingly relies on the role of proteins as key components in cancer diagnosis, prognosis, and targeted therapy. This review examines advancements in protein biomarkers across several cancer types, including breast cancer, lung cancer, ovarian cancer, and hepatocellular carcinoma. These biomarkers have proven critical for early detection, treatment response monitoring, and tailoring personalized therapeutic strategies. The article highlights the utility of targeted therapies, such as tyrosine kinase inhibitors and monoclonal antibodies, in improving treatment efficacy while minimizing systemic toxicity. Despite these advancements, challenges like tumor resistance, variability in protein expression, and diagnostic heterogeneity persist, complicating universal application. The review underscores future directions, including the integration of artificial intelligence, advanced protein analysis technologies, and the development of combination therapies to overcome these barriers and refine personalized cancer treatment.

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Role of Proteins in Oncology: Advances in Cancer Diagnosis, Prognosis, and Targeted Therapy—A Narrative Review

Kędzierska,

Bańkosz

2024

JCM

View full text Add to dashboard Cite

show abstract

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PD-L1 and PD-1 in immune regulation and their implications in blood cancers

Cited by 1 publication

References 112 publications

Role of Proteins in Oncology: Advances in Cancer Diagnosis, Prognosis, and Targeted Therapy—A Narrative Review

Role of Proteins in Oncology: Advances in Cancer Diagnosis, Prognosis, and Targeted Therapy—A Narrative Review

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