Pd39-07 overall Adverse Events of Drugs for Metastatic Renal Cell Carcinoma: Real World Reporting Patterns From Eudra Vigilance Database

Abstract

EGFR-20-CTF expression was < 16 months. GSEA showed that EGFR-20-CTF correlated with a significant decrease in expression of gene sets related to immune response including the HALLMARK inflammatory response, IL-2 signaling, and INF gamma response (all FDR q-val < 0.001).CONCLUSIONS: EGFR-20-CTF occurs frequently in patients with ccRCC and is enriched in patients who had a poor response to immunotherapy. The presence of the EGFR-20-CTF was associated with a global decrease in expression of several gene sets related to immune response, which could account for the decreased response to immunotherapy observed in these patients. This previously unrecognized splice variant presents a possible marker of resistance and will need prospective validation.