Pdb6 Relative Effectiveness Management of Type Ii Diabetes in Europe: Can the Agencies' Demands Be Met?

Hemels, M.; Jensen, Rcø; Toumi, M; Adalsteinsson, E

doi:10.1016/s1098-3015(10)72253-1

Cited by 1 publication

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“…In this respect, metformin-containing dosage forms ensuring its prolonged release in the upper gastrointestinal tract would represent a major step forward in the current treatment of diabetes [60]. Besides increasing therapy effectiveness and possibly limiting the risk of patient hospitalization for uncontrolled symptoms, the therapeutic approach involving the use of GRDDSs would have a major impact on the costs associated with diabetes, which in Europe were estimated to be around € 2850 for each subject yearly [65][66][67][68][69][70].…”

Section: Introductionmentioning

confidence: 99%

Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin

Uboldi,

Chiappa,

Rossi

et al. 2023

Expert Opinion on Drug Delivery

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Objectives Efficacy and compliance of type II diabetes treatment would greatly benefit from dosage forms providing controlled release of metformin in the upper gastrointestinal tract. In this respect, the feasibility of a new system ensuring stomach-retention and personalized release of this drug at its absorption window for multiple days was investigated. MethodsThe system proposed comprised of a drug-containing core and a viscoelastic umbrella-like skeleton, which were manufactured by melt-casting and 3D printing. Prototypes, alone or upon assembly and insertion into commercially-available capsules, were characterized for key parameters: thermo-mechanical properties, accelerated stability, degradation, drug release, deployment performance and resistance to simulated gastric contractions.Results Each part of the system was successfully manufactured using purposely-selected materials and the performance of final prototypes matched the desired one. This included: i) easy folding of the skeleton against the core in the collapsed administered shape, ii) rapid recovery of the cumbersome configuration at the target site, even upon storage and iii) prolonged release of metformin.Conclusions Composition, geometry and performance of the system developed in this work were deemed acceptable for stomach retention and prolonged as well as customizable release of metformin at its absorption window, laying promising bases for further development steps.

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