PDE-5 inhibitors: patients’ preferences

Efremov, E.A.; Kasatonova, E. V.; Melnik, Ya I; Nikushina, A.A. Nikushina

doi:10.18565/urol.2017.3.120-126

Cited by 2 publications

(2 citation statements)

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“…This formulation especially benefits patients who have difficulty in swallowing and who are on liquid restriction (eg, patients with renal impairment, endocrine system, and adrenal gland disorders). 9 , 10 , 11 , 12 , 13 …”

Section: Introductionmentioning

confidence: 99%

Bioequivalence Studies of Sildenafil Citrate Orodispersible Film Administered with and without Water vs ViagraⓇ Film-Coated Tablets in Healthy Male Volunteers

Shaw,

Lawrence,

Yan

et al. 2023

Current Therapeutic Research

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Section: Introductionmentioning

confidence: 99%

Bioequivalence Studies of Sildenafil Citrate Orodispersible Film Administered with and without Water vs ViagraⓇ Film-Coated Tablets in Healthy Male Volunteers

Shaw,

Lawrence,

Yan

et al. 2023

Current Therapeutic Research

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“…Sildenafil orodispersible film (ODF) is one of the novel formulations that have been recently made available. Sildenafil ODF disintegrates in the mouth without the need for water and could offer several advantages over conventional film-coated tablet formulations for patients with ED 19, 20, 21, 22, 23…”

Section: Introductionmentioning

confidence: 99%

Needs and Expectations of Patients with Erectile Dysfunction: An Update on Pharmacological Innovations in Phosphodiesterase Type 5 Inhibition with Focus on Sildenafil

Jannini

Droupy

2018

Sexual Medicine

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Introduction Phosphodiesterase type 5 inhibitors (PDE5-Is) have an excellent efficacy and tolerability profile and remain the first-line choice for the treatment of erectile dysfunction (ED). However, ED is still an underdiagnosed and undertreated condition, and many men prematurely discontinue therapy with conventional dosage formulations despite successful intercourse. Aim To review the unmet needs and expectations of patients with ED and describe the latest pharmaceutical innovations in the field of PDE5-I formulations designed to address these needs, with particular reference to a new orodispersible film (ODF) formulation of the PDE5-I, sildenafil. Methods Online literature search in PubMed and the Cochrane Library. Main Outcome Measure To identify English-language publications relevant to the aims of the present review. Results Improved recognition and management of ED would enable the early diagnosis of underlying and comorbid conditions that contribute to ED, leading to improved patient health and health-related quality of life. To ensure successful outcomes and patient and partner satisfaction, the complex and personal issues that influence the patient’s needs and expectations regarding treatment for ED must be considered along with their personal experiences and preferences. Innovative drug delivery systems, including orally disintegrating formulations, have been developed as alternatives to conventional dosage forms with the aim of improving patient convenience and acceptability and enhancing compliance. These alternative formulations include the sildenafil ODF, which is designed to improve acceptance and compliance over conventional solid dosage forms and extend the treatment options for men with ED by offering a convenient and discrete dosage form of a drug with proven efficacy. Conclusion The sildenafil ODF is an example of an innovative dosage formulation for ED that can be used interchangeably with the conventional film-coated formulation to better address the needs and expectations of men with ED. Jannini EA, Droupy S. Needs and Expectations of Patients with Erectile Dysfunction: An Update on Pharmacological Innovations in Phosphodiesterase Type 5 Inhibition with Focus on Sildenafil. Sex Med 2019;7:1–10.

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PDE-5 inhibitors: patients’ preferences

Cited by 2 publications

References 0 publications

Bioequivalence Studies of Sildenafil Citrate Orodispersible Film Administered with and without Water vs ViagraⓇ Film-Coated Tablets in Healthy Male Volunteers

Bioequivalence Studies of Sildenafil Citrate Orodispersible Film Administered with and without Water vs ViagraⓇ Film-Coated Tablets in Healthy Male Volunteers

Needs and Expectations of Patients with Erectile Dysfunction: An Update on Pharmacological Innovations in Phosphodiesterase Type 5 Inhibition with Focus on Sildenafil

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