2021
DOI: 10.1080/02713683.2021.1966479
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PDGF as an Important Initiator for Neurite Outgrowth Associated with Fibrovascular Membranes in Proliferative Diabetic Retinopathy

Abstract: Purpose:The formation of fibrovascular membranes (FVMs) is a serious sight-threatening complication of proliferative diabetic retinopathy (PDR) that may result in retinal detachment and eventual blindness. During the formation of these membranes, neurite/process outgrowth occurs in retinal neurons and glial cells, which may both serve as a scaffold and have guiding or regulatory roles. To further understand this process, we investigated whether previously identified candidate proteins, from vitreous of PDR pat… Show more

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Cited by 10 publications
(4 citation statements)
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“…PDGF-BB is another pro-angiogenic factor (Heldin and Westermark 1999 ) which is implicated in the development of proliferative retinopathies when PDGF activity is excessive (Lefevere et al. 2022 ). Sipjeondaebo-Tang (SDT), a traditional formula used widely for a long time, has been shown to reduce the expression of PDGF-AB/BB compared to the model group.…”
Section: Methodsmentioning
confidence: 99%
“…PDGF-BB is another pro-angiogenic factor (Heldin and Westermark 1999 ) which is implicated in the development of proliferative retinopathies when PDGF activity is excessive (Lefevere et al. 2022 ). Sipjeondaebo-Tang (SDT), a traditional formula used widely for a long time, has been shown to reduce the expression of PDGF-AB/BB compared to the model group.…”
Section: Methodsmentioning
confidence: 99%
“…Apart from VEGF, other key molecules involved in neovascularization in DR include platelet-derived growth factor (PDGF), placental growth factor (PlGF) and others. Platelet-derived growth factors are secreted by platelets, endothelial cells, activated macrophages and smooth muscle cells and are vital players of DR ( 49 51 ); PDGF has 4 polypeptide chains(PDGF-A, PDGF-B, PDGF-C, and PDGF-D) and becomes active by homodimer isoform formation such as PDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD or heterodimeric form PDGF-AB. PDGF ligands will bind to transmembrane tyrosine kinase PDGF receptors, which contain homodimeric and heterodimeric isoforms such as PDGFR-αα, PDGFR-ββ and PDGFR-αβ ( 50 ).…”
Section: Neovascularization In Diabetic Retinopathymentioning
confidence: 99%
“…In the mouse retinal vasculature, active Notch1, Jag1, Dll1 and Dll4 have been described with distinct distribution patterns ( 140 ). Cellular analysis and gene inactivation or mutation of mouse or zebrafish retinas, combined with ocular disease models, have demonstrated that Notch signaling plays an important role in embryonic and postnatal ocular angiogenesis and is involved in angiogenic ocular diseases ( 141 ). Recent findings show that NOTCH1 signaling in retinal microvascular endothelial cells induces vascular permeability in diabetes: NOTCH1 ligands JAGGED1 and DELTA LIKE-4 are secondary to hyperglycemia and activate the canonical and rapid atypical NOTCH1 pathways, ultimately disrupts adherent junctions between endothelial cells by causing diabetic endothelial dissociation ( 142 ).…”
Section: Classic Regulators Of the Endothelial Dysfunction Of Diabeti...mentioning
confidence: 99%