PDGF-loaded microneedles promote tendon healing through p38/cyclin D1 pathway mediated angiogenesis

Liu, Xuanzhe; Li, Yuange; Wang, Shuo; Lu, Mingkuan; Zou, Jian; Shi, Zhongmin; Xu, Bin; Wang, Wei; Hu, Bo; Jin, Tao; Wu, Fei; Liu, Shen; Fan, Cunyi

doi:10.1016/j.mtbio.2022.100428

Cited by 9 publications

(2 citation statements)

References 56 publications

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“…It has been reported that Mn deficiency results in impairment of cell adhesion, proliferation, and differentiation ( 45 ). Furthermore, Mn ions display a positive effect on angiogenesis which is essential for osteogenic and tenogenic processes ( 36 , 46 , 47 ). Notably, Mn-containing biomaterials also have been confirmed to inhibit the expression of typical pro-inflammatory genes, such as TNF- α, IL-6 , OSM , and IL-1 β.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration

Du,

Wu,

Han

et al. 2024

Sci. Adv.

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Limited motor activity due to the loss of natural structure impedes recovery in patients suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening the regenerative ability of tendons/bones to restore natural structure. However, owing to ignoring the immune environment and lack of multi-tissue regenerative function, satisfactory outcomes remain elusive. Here, combined manganese silicate (MS) nanoparticles with tendon/bone-related cells, the immunomodulatory multicellular scaffolds were fabricated for integrated regeneration of tendon-to-bone. Notably, by integrating biomimetic cellular distribution and MS nanoparticles, the multicellular scaffolds exhibited diverse bioactivities. Moreover, MS nanoparticles enhanced the specific differentiation of multicellular scaffolds via regulating macrophages, which was mainly attributed to the secretion of PGE2 in macrophages induced by Mn ions. Furthermore, three animal results indicated that the scaffolds achieved immunomodulation, integrated regeneration, and function recovery at tendon-to-bone interfaces. Thus, the multicellular scaffolds based on inorganic biomaterials offer an innovative concept for immunomodulation and integrated regeneration of soft/hard tissue interfaces.

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Section: Introductionmentioning

confidence: 99%

Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration

Du,

Wu,

Han

et al. 2024

Sci. Adv.

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“…One is transdermal delivery of active substances with MNs to promote tissue regeneration. For example, hyaluronic acid (HA) MNs to enhance transdermal uptake of exosomes for Achilles tendon repair [ 39 ], polyvinyl alcohol (PVA) MNs loaded with carbonized wormwood and inflammatory factors for skeletal muscles repair [ 40 ], and PVA MNs loaded with platelet derived growth factor for tendon healing [ 41 ]. Another is to use MNs as the scaffold for ISTR to enhance the healing ability of damaged tissues [ 13 , 42 , 43 ], which is also the focus of the present review.…”

Section: Introductionmentioning

confidence: 99%

Microneedles for in situ tissue regeneration

Long¹,

Ji²,

Hu³

et al. 2023

Materials Today Bio

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CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway

Chen,

Zheng,

Wang

et al. 2024

Advanced Science

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Tendinopathy poses a formidable challenge due to the inherent limitations of tendon regenerative capabilities post‐injury. At present, effective curative approaches for tendinopathy are still lacking. Collagen triple helix repeat‐containing 1 (CTHRC1) is an extracellular matrix protein with significant roles in both physiological and pathological processes. The present study aims to investigate the function and underlying mechanism of CTHRC1 in tendinopathy. In this study, CTHRC1 is identified as a potential effector in promoting tendon regeneration through multi‐proteomic analysis of Achilles tendon tissues in mice. In vitro, CTHRC1 enhances the proliferation, migration, and tenogenic differentiation of tendon stem/progenitor cell (TSPC). In vivo, CTHRC1 deletion impairs tendon healing, while its overexpression reverses the detrimental effects caused by CTHRC1 deficiency. Mechanistically, proteomics on TSPC stimulated with recombinant CTHRC1 reveal that CTHRC1 activates the mitogen‐activated protein kinase (MAPK) signaling pathway via binding to epidermal growth factor receptor (EGFR), which in turn promotes the proliferative, migrative, and tenogenic capacities of TSPC to attenuate Achilles tendinopathy. Conversely, inhibiting EGFR reverses the tendon‐healing effect of CRHRC1. The study demonstrates that CTHRC1 can promote the proliferative, migrative, and tenogenic capacities of TSPC, ultimately facilitating tendon healing through activating the EGFR/MAPK signaling pathway. CTHRC1 holds promise as a potential intervention for tendinopathy.

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PDGF-loaded microneedles promote tendon healing through p38/cyclin D1 pathway mediated angiogenesis

Cited by 9 publications

References 56 publications

Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration

Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration

Microneedles for in situ tissue regeneration

CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway

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