PdII–PdII bonding interaction in dinuclear PdII complex with non-macrocyclic (O&amp;N) chelates: Characterization, kinetics and DFT study

Pincer PdII–isocyanide complexes are described that display intermolecular interactions and emissive 3MMLCT excited states in aggregation state(s) at room temperature. The intermolecular PdII−PdII and ligand–ligand interactions drive these complexes to undergo supramolecular polymerization in a living manner. Comprehensive spectroscopic studies reveal a pathway with a kinetic trap that can be modulated by changing the counteranion and metal atom. The PdII supramolecular assemblies comprise two different aggregation forms with only one to be emissive. DFT/TDDFT calculations lend support to the MMLCT absorption and emission of these pincer PdII–isocyanide aggregates.

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The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer Pd^II–Isocyanide Complexes

Wan

Yang

et al. 2018

Angewandte Chemie

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The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer Pd^II–Isocyanide Complexes

Wan

Yang

et al. 2018

Angew Chem Int Ed

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In Vitro DNA/BSA Binding, Anticancer and Normal Cell Activity of Pd(II) Complexes: Substitution Behaviour and Computational Study

et al. 2018

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In the aspect of an effective palladium based anticancer drug design, Pd(II) complexes [Pd(MAMP)Cl2], C1; [Pd(MAMP)(H2O)2]x2, C2; [Pd(MAMP)(L‐cys)]x, C3; [Pd(MAMP)(N‐ac‐L‐cys)], C4; [Pd(MAMP)(DL‐meth)]x2, C5; and [Pd(MAMP)(DL‐pen)]x, C6 (where x=ClO4−/NO3−) have been synthesised and characterised where 2‐[(methylamino)methyl]pyridine (MAMP) has been considered as carrier ligand and chloride, aqua, L‐cysteine (L‐cys), N‐acetyl‐L‐cysteine (N‐ac‐L‐cys), DL‐methionine (DL‐meth) and DL‐penicillamine (DL‐pen) are selected as leaving group. DNA as well as protein binding ability of the complexes has been investigated with CT‐DNA and BSA and the related binding parameters have been evaluated. Kinetic investigation for the reactions of Pd(II)‐diaqua complex C2 with four selected sulfur containing bio‐molecules have been carried out under pseudo first order condition. In addition, theoretical investigation has also been considered for structural optimisation, frontier molecular orbital mapping, TD‐DFT and NBO analysis. To get an insight into the cytotoxicity, the complexes have been treated on three different cancer cell lines (A549, HeLa, Hep G2) which reveal comparable anticancer activity of the reported complexes with the clinically acquainted anticancer drug Cisplatin. Very less complex initiated reactive oxygen species (ROS) with low degree of cell death in two different non‐tumour cell lines (L6 myotubes and HEK 293) indicate minimum normal cell toxicity of the complexes.

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PdII–PdII bonding interaction in dinuclear PdII complex with non-macrocyclic (O&N) chelates: Characterization, kinetics and DFT study

Cited by 16 publications

References 61 publications

The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer Pd^II–Isocyanide Complexes

The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer Pd^II–Isocyanide Complexes

The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer Pd^II–Isocyanide Complexes

In Vitro DNA/BSA Binding, Anticancer and Normal Cell Activity of Pd(II) Complexes: Substitution Behaviour and Computational Study

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PdII–PdII bonding interaction in dinuclear PdII complex with non-macrocyclic (O&N) chelates: Characterization, kinetics and DFT study

Cited by 16 publications

References 61 publications

The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer PdII–Isocyanide Complexes

The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer PdII–Isocyanide Complexes

The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer PdII–Isocyanide Complexes

In Vitro DNA/BSA Binding, Anticancer and Normal Cell Activity of Pd(II) Complexes: Substitution Behaviour and Computational Study

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Product

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The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer Pd^II–Isocyanide Complexes

The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer Pd^II–Isocyanide Complexes

The Metal–Metal‐to‐Ligand Charge Transfer Excited State and Supramolecular Polymerization of Luminescent Pincer Pd^II–Isocyanide Complexes