Peak expiratory flow monitoring in asthmatic children

Fonseca, Ana Cristina; Fonseca, Maria Tereza M; Rodrigues, Mary Elisabeth Santos Moura; Lasmar, Laura Maria de Lima Belizário Facury; Camargos, Paulo Augusto Moreira

doi:10.2223/jped.1566

Cited by 17 publications

(15 citation statements)

References 11 publications

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“…Um dispositivo externo é responsável pela geração de pressões oscilatórias que são aplicadas ao interior do sistema respiratório através de um bocal. Um sinal de fluxo é refletido a cada pulso gerado, medido por um pneumotacógrafo, fornecendo dados que possibilitem análise sobre a função pulmonar dos indivíduos (FONSECA AC et al, 2006;LARSEN G et al, 2009).…”

Section: Discussão E Conclusãounclassified

Avaliação Do Perfil Dos Pacientes Com Síndrome Da Apneia Obstrutiva Do Sono E Outras Comorbidades Em Um Serviço De Fisioterapia

Cruz¹,

Machado²,

Andrade³

et al. 2020

Fisioterapia Na Atenção À Saúde

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. A Atena Editora não se responsabiliza por eventuais mudanças ocorridas nos endereços convencionais ou eletrônicos citados nesta obra. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação.

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Section: Discussão E Conclusãounclassified

Avaliação Do Perfil Dos Pacientes Com Síndrome Da Apneia Obstrutiva Do Sono E Outras Comorbidades Em Um Serviço De Fisioterapia

Cruz¹,

Machado²,

Andrade³

et al. 2020

Fisioterapia Na Atenção À Saúde

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“…Another traditional endpoint – PEF – has also been shown not to correlate with asthma severity in children. Instead, PEF correlates with FEV 1 , suggesting this test may also have limitations as an asthma outcome measurement in children with asthma 72. In addition, portable PEF meters allow for self-monitoring at home, which can be beneficial for children, although all patients need to be observed carefully, as it has been reported that many patients, both adults and children, do not use the PEF meters correctly 73…”

Section: Challenges For Future Clinical Trials In Pediatric Asthmamentioning

confidence: 99%

<p>Clinical efficacy and safety of anticholinergic therapies in pediatric patients</p>

Goldstein¹

2019

TCRM

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The burden of uncontrolled asthma in children and adolescents is high. Treatment options for pediatric patients (aged under 18 years) with asthma are largely influenced by the Global Initiative for Asthma recommendations. Algorithms for adolescents (12–18 years) and adults are identical, but recommendations for children aged under 6 years and 6–11 years differ. Although the goals of treatment for pediatric patients with asthma are similar to those for adults, relatively few new therapies have been approved for this patient population within the last decade. Designing clinical trials involving children presents several challenges, notably that children are often less able to perform lung function tests, and traditional endpoints used in clinical trials with adults, such as forced expiratory volume in 1 second, asthma exacerbations and questionnaires, have limitations associated with their use in children. There are also ethical considerations related to the performance of longer placebo-controlled exacerbation trials. This review considers additional clinical endpoints to those traditionally reported, including forced expiratory flow at 25%–75% of forced vital capacity, which may help shed light on which treatments are most effective for use in pediatric patients with asthma. The pros and cons of specific and potentially clinically relevant endpoints are considered, along with device considerations and patient preferences that may enhance adherence and quality of life. Recent advances in the management of children and adolescents, including the US Food and Drug Administration and European Medicines Agency approval of tiotropium in patients with asthma aged 6 years and over, are also discussed.

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“…However, especially during childhood, the management of asthmatic patients based solely on symptoms and pulmonary function might be a mistake, since the perception of symptoms and its correlation with the pulmonary function can vary. 10,11 In addition to these aspects, it is important to consider that the alterations in the pulmonary function might be permanent due to remodeling of bronchial mucosa. Thus, the evaluation of pulmonary function is insufficient to assess the therapeutic response.…”

Section: Introductionmentioning

confidence: 99%

Avaliação da inflamação com base na liberação de radicais oxidantes por granulócitos na asma crônica não-controlada

Sartorelli¹,

Rehder²,

Neto³

et al. 2009

J. Pediatr. (Rio J.)

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Objective: To evaluate spontaneous release of superoxide anion by peripheral blood granulocytes of atopic patients with uncontrolled asthma undergoing glucocorticoid therapy and of healthy subjects. Methods:We studied 32 patients, aged 6 to 18 (mean 12.04), and 29 healthy subjects as a comparative group.Patients were grouped according to the forced expiratory vital capacity in the first second. Group I, forced expiratory vital capacity in the first second of between 60 and 80%, had 19 patients, and group II, forced expiratory vital capacity in the first second = 60%, had 13 patients. Spontaneous superoxide release by granulocytes was measured by a spectrophotometer method based on superoxide dismutase, before and after oral prednisone and beclomethasone, budesonide or fluticasone inhaled therapy. Statistical analyses were performed using ANOVA, Wilcoxon and Tukey tests. Results:Comparing the superoxide anion release by granulocytes of asthmatic patients and healthy subjects, we observed a higher release by cells of the uncontrolled patient group II (p < 0.05). Evaluating the superoxide release by cells of asthmatic patients before and after steroid therapy, a significant decrease was found only in patient group I. Conclusion:The impact of corticosteroids on inflammatory modulation occurred in the uncontrolled asthmatics with forced expiratory vital capacity in the first second between 60 and 80%. In those with forced expiratory vital capacity in the first second of = 60%, this finding was not observed. Further studies are necessary to evaluate the effect of this finding on asthmatic patients.

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Peak expiratory flow monitoring in asthmatic children

Cited by 17 publications

References 11 publications

Avaliação Do Perfil Dos Pacientes Com Síndrome Da Apneia Obstrutiva Do Sono E Outras Comorbidades Em Um Serviço De Fisioterapia

Avaliação Do Perfil Dos Pacientes Com Síndrome Da Apneia Obstrutiva Do Sono E Outras Comorbidades Em Um Serviço De Fisioterapia

<p>Clinical efficacy and safety of anticholinergic therapies in pediatric patients</p>

Avaliação da inflamação com base na liberação de radicais oxidantes por granulócitos na asma crônica não-controlada

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