Peanut leaf extract has antioxidant and anti-inflammatory activity but no acute toxic effects

Cossetin, Jocelene Filippin; Brum, Evelyne da Silva; Casoti, Rosana; Camponogara, Camila; Dornelles, Rafaela Castro; Maziero, Maiara; Antoniazzi, Caren Tatiane de David; Guex, Camille Gaube; Ramos, Andiara Prates; Pintos, Francielle Guedes; Engelmann, Ana Martiele; Andrade, Cínthia Melazzo de; Manfron, Melânia Palermo; Oliveira, Sara Marchesan; Bauermann, Liliane de Freitas; Sagrillo, Michele Rorato; Machado, Alencar Kolinski; Santos, Adair R.S.; Trevisan, Gabriela

doi:10.1016/j.yrtph.2019.104407

Cited by 16 publications

(13 citation statements)

References 71 publications

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“…Additionally, Limmongkon et al (63) observed that a peanut seed-derived ethanolic extract inhibited the LOX enzyme, with an IC 50 of 0.01 mg/mL. Cossetin et al (64) obtained a peanut leaf extract using 70% ethanol. Which contained condensed tannins, flavonoids, and phenolic compounds (10-100 μg/mL); and detected that the extract decreased NO production and IL-1β levels (10 μg/mL) induced by previous exposure to H 2 O 2 in human peripheral blood mononuclear cells (PBMCs).…”

Section: In Vitro Studiesmentioning

confidence: 99%

Potential anti-inflammatory effects of legumes: a review

et al. 2022

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Legumes are a staple of diets all around the world. In some least developed countries, they are the primary source of protein; however, their beneficial properties go beyond their nutritional value. Recent research has shown that legumes have bioactive compounds like peptides, polyphenols, and saponins; which exhibit antioxidant, antihypertensive, anti-inflammatory, and other biological activities. Thus, these compounds could be an alternative treatment for inflammatory diseases, in particular, chronic inflammation such as arthritis, obesity, and cancer. Nowadays, there is a growing interest in alternative therapies derived from natural products; accordingly, the present review has compiled the bioactive compounds found in legumes that have demonstrated an anti- inflammatory effect in non-clinical studies.

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Section: In Vitro Studiesmentioning

confidence: 99%

Potential anti-inflammatory effects of legumes: a review

et al. 2022

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“…TEE and SEE toxicity was similar to that of the peanut leaf hydroalcoholic extract, which at concentrations of 1, 10, and 100 μg/ml neither produce cell damage after 24 h of incubation ( Cossetin et al., 2019 ).…”

Section: Resultsmentioning

confidence: 69%

Evaluation of cellular safety and the chemical composition of the peanut (Arachis hypogaea L.) ethanolic extracts

Candela

Giordano

Quiroga

et al. 2020

Heliyon

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Arachis hypogaea L. (Leguminosae) is distributed in tropical and subtropical areas. Peanut has high nutritional and commercial value. Scientific research showed that peanut has biological properties such as anticancer, antioxidant, antiinflammatory. However, it is necessary to know if consumption of peanut, either as food or as a phytopharmaceutical implies a health risk. The aim was to evaluate cytotoxicity and genotoxicity of ethanolic extracts from A. hypogaea . Also, chemical characterization of these extracts was performed. Cytotoxicity was evaluated by MTT and Neutral Red Uptake (NRU) assays on Vero cells. Genotoxicity was studied by Micronuclei and comet assays on Balb/C mice. Qualitative and quantitative chemical analysis of extracts were performed. Results showed that extracts have low cytotoxicity. Tegument ethanolic extract (TEE) and Seed ethanolic extract (SEE) were not genotoxic. The treatments with TEE at 250 mg/kg and SEE at 2000 mg/kg revealed (highest concentrations evaluated) some toxicity on blood marrow cells of mice. Chemical characterization indicated that TEE had 74.33 ± 1.10 mg GAE/g of dried extract and SEE had 15.05 ± 0.06 mg GAE/g of dried extract of total phenolic content. Also, proanthocyanidins (O.D. at 550 nm 1.39 ± 0.15) and caffeic acid (2.46%) were identified in TEE. While, linoleic acid (58.84%) oleic acid (11.31%) and palmitic acid (8.37%) were major compounds of SEE. In conclusion, peanut consumption is safe at concentrations recommended for healthy uses, such as nutrition, and phytomedicine.

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“…Peanut leaves have an ample amount of resveratrol which is a strong antioxidant and anti-inflammatory compound (Cossetin et al, 2019).…”

Section: Nutsmentioning

confidence: 99%

Diet and lifestyle modifications: An update on non‐pharmacological approach in the management of osteoarthritis

Shahid

Inam‐Ur‐Raheem

Haq

et al. 2022

Food Processing Preservation

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Osteoarthritis (OA) is a degenerative joint disease, a leading cause of bone-related disabilities affecting the quality of life of a huge segment of the global population. To eradicate this problem, non-pharmacological treatments like diet and lifestyle modification (weight loss, Tai chi, cupping therapy, kinesio taping, ultrasound and wholebody vibration, low-level laser therapy, manual therapy, electrotherapy, mudpack therapy, and moxibustion) are effective along with medical treatments. Nowadays, these preventive and therapeutic remedies are getting more attention as adjuvant measures due to enhanced awareness among the common people. In most OA management guidelines, dietary modifications along with effective exercises and therapies are preferred over other existing treatments owing to their safe nature and significant positive effects on reverting the OA symptoms. Scientific evidence has shown that food components such as phytochemicals, polyphenols, flavonoids, epigallocatechin 3-gallate, ellagic acid (EA), vitamins, minerals, extracellular vesicles, glucosamine, and chondroitin sulfate have a promising effect on relieving the OA symptoms and slowing down its progression due to their antioxidant and anti-inflammatory activities. This review summarizes the evidence-based dietary and lifestyle modifications for improved bone health with special reference to OA. Novelty impact statement:This review summarizes the evidence-based nonpharmacological approach with reference to diet (phytochemicals, antioxidants, nutrients), lifestyle modification (exercises, other therapies), and comments on the effect of food processing on bioactive compounds in the management of OA. This data can serve as a benchmark or guideline for clinicians, practitioners, researchers, and patients to manage the OA.

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Peanut leaf extract has antioxidant and anti-inflammatory activity but no acute toxic effects

Cited by 16 publications

References 71 publications

Potential anti-inflammatory effects of legumes: a review

Potential anti-inflammatory effects of legumes: a review

Evaluation of cellular safety and the chemical composition of the peanut (Arachis hypogaea L.) ethanolic extracts

Diet and lifestyle modifications: An update on non‐pharmacological approach in the management of osteoarthritis

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