Pyroxasulfone is a residual herbicide developed for use in several agronomic crops such as corn (Zea mays L.), soybean (Glycine max L.), wheat (Triticum aestivum L.), and sunflower (Helianthus annuus L.). Pyroxasulfone provides effective preemergence (PRE) control of annual grasses and broadleaf weeds, but little is known about peanut cultivar tolerance. Therefore, field trials were conducted in Georgia during 2012 and 2013 to evaluate peanut cultivars 'Georgia-06G', 'Georgia Greener', and 'Tifguard' response to pyroxasulfone applied PRE at 0, 120, or 240 g ai/ ha. Greater stunting occurred during 2012 than 2013. Peanut stunting 10 days after planting (DAP) during 2012 and 2013 ranged from 38 to 55% and 3 to 11%, respectively. At 10 DAP, greater injury was observed in 'Tifguard' as compared to 'Georgia-06G' with pyroxasulfone at 120 g ai/ha. 'Georgia Greener' was injured more than 'Tifguard' following the 240 g ai/ha rate of pyroxasulfone. By 120 DAP, peanut had recovered substantially from stunting caused by PRE applications of pyroxasulfone with no cultivar interactions. Peanut yield was influenced by pyroxasulfone rate when applied PRE. Peanut yield was 7,140 kg/ha in treatments that did not include pyroxasulfone. Treatments that included pyroxasulfone at 120 g ai/ha yielded similar to treatments without pyroxasulfone. Peanut yield was reduced to 6,750 kg/ha (7%) following pyroxasulfone applied at 240 g ai/ha. When combined over pyroxasulfone rate, 'Georgia-06G' produced greater yields than the other cultivars.