Pearls in the Management of Acne

Usatine, Richard P.; Quan, Martin

doi:10.1016/s0095-4543(05)70196-2

Cited by 14 publications

(19 citation statements)

References 27 publications

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“…Most of the patients were highly competitive professionals. The aetiology is poorly understood and the purpose of treatment is the reduction of lesions with appropriate topical and oral medications, with consequent physical and psychological well‐being, despite treatment being expensive and long‐lasting…”

Section: Psychologymentioning

confidence: 99%

Acne in women

2015

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SummaryThis review focuses on the subject of acne in women, a disease that is increasingly common and that can also affect men. Adult acne differs from the type of acne that occurs in teenagers, and it may persist beyond adolescence or have its onset at an older age (adult-onset acne or late acne). Acne can have a negative impact on the quality of life of patients at any age, leading to a negative body image and decrease in self-esteem, and in older patients it can result in discrimination in the workplace and in other social environments. Acne in women must be understood as a specific problem, and here we discuss the pathogenesis, clinical presentation, psychology and treatment of this very prevalent problem.Acne is most common in teenagers, but so-called physiological acne in adults can be seen in 54% of women and 40% of men, and its prevalence does not decrease substantially with age.1,2 The majority of adult cases can be classified as persistent, occurring especially in women, while in boys acne usually disappears after adolescence. However, there are cases of truly late-onset acne (occurring after 25 years of age), 2 and in the last decade there has been an increase in the age of onset, mainly in women aged 20Á5-26Á5 years. Acne in women differs from that seen in adolescents, showing a predominance of papules and pustules, with an absence of comedones. These were cases formerly diagnosed as acneiform eruption and not as true acne, as they were assumed to be precipitated by external agents such as drugs, cosmetics, chemical products etc. 2,3Acne can cause psychological disturbances and have a negative impact on the quality of life of patients at any age, 1 leading to a negative body image and decrease in selfesteem, as well as discrimination in the workplace and in other social environments.4,5 Consequently, successful therapy offers, without doubt, much more than just cosmetic benefits. Acne in women must be understood as a specific problem, different from the form we see occurring in teenagers, and, as such, it must be understood and treated seriously, even in mild cases. PathogenesisAcne has a multifactorial pathogenesis, but the androgenic stimulus of the sebaceous glands certainly plays a role. Despite the fact that sebaceous secretion is under genetic control, acne probably results from an exacerbated response of the pilosebaceous unit to the normal circulating androgen levels.6,7 Studies have found increased levels of circulating androgens in some female patients. [8][9][10] Acne in women is a disorder that is particularly sensitive to hormonal changes during the menstrual cycle, and almost 70% of women who were assessed in a study reported worsening of the lesions during the premenstrual period. 11 Clinical presentationThe severity of acne in women tends to vary from mild to moderate, comprising mainly inflammatory lesions. Two main subtypes can be identified: persistent acne and late-onset acne (beginning after the age of 25 years), which are responsible for 80% and 20% of cases, respectively. 12 Wo...

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Section: Psychologymentioning

confidence: 99%

Acne in women

2015

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“…Patients who had been treated for acne with topical agents, systemic antibiotics, or isotretinoin within the preceding 15 days, one month, or six months, respectively, and those who had severe acne vulgaris according to the acne grading system of the American Academy of Dermatology were excluded (2).…”

Section: Methodsmentioning

confidence: 99%

Benzoyl Peroxide, Adapalene, and Their Combination in the Treatment of Acne Vulgaris

Korkut

Pişkin

2005

The Journal of Dermatology

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Benzoyl peroxide and adapalene are among the most effective topical agents used in the treatment of acne. We planned an open-labeled, prospective study to compare the effects and side effects of these two drugs alone and in combination in the treatment of acne vulgaris. One hundred and five consecutive patients (30 men and 75 women) with acne vulgaris were included in this study. The patients were randomly divided into three groups with 35 patients in each. The groups were randomly assigned to 0.1% adapalene gel, 5% benzoyl peroxide lotion, or combination of 0.1% adapalene gel +5% benzoyl peroxide treatment. Acne lesions were classified as noninflammatory (open and closed comedones) and inflammatory (papule, pustule, nodule, cyst), and the lesions on the face were counted before the therapy, during the control visits, and after the treatment. Erythema, dryness, burning, and other side effects were recorded during the treatment. The mean age of the patients was 18.44 +/- 3.75 years. Eight patients were excluded because of noncompliance with the treatment regimen or the follow-up schedule, and four patients were excluded due to allergic contact dermatitis. The study revealed that all three therapy protocols were effective in treating noninflammatory and inflammatory lesions in acne vulgaris (p<0.05) and that there was no significant difference between the groups in efficacy or side effects (p>0.05). Adapalene and benzoyl peroxide are effective and well tolerated agents for acne vulgaris; combination therapy has no superiority over adapalene or benzoyl peroxide alone.

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“… In order to attain a follicular targeting, the adapalene is integrated with the microcrystals (with a size range of 3-10 µm) 14 .…”

Section: C) Adapalenementioning

confidence: 99%

“…It is used in the treatment of mild to moderate acne. Commercially, it is available as a gel (0.05 %, 0.1%) which is applied daily in the evening only once 14 .…”

Section: D) Tazarotenementioning

confidence: 99%

Untitled

2019

IJPSR

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Acne is a common inflammatory disorder which is common among the adolescent age groups. Even though it is not a life-threatening disease but it affects the patient's self-esteem. Additionally, they have also gone into depression and suicidal ideation. Based on the severity it can be classified into several types. Various factors are responsible for the occurrence of acne. The main factors are discussed in this article. According to the Global Burden of Disease study about 85% of the populations are being affected when we consider the epidemiology. Among this, the Americans are most prone to it. A variety of medications are available in the market for the treatment of acne like retinoid derivatives, benzoyl peroxide, and antibiotics etc. Among which the topical treatment is most preferred. Other treatments are carried out only if the existing treatment doesn't give the desired results. Nanotechnology has also been incorporated for the existing drug in order to target the disease. Acne can be induced in the animal. Existing works of literature gives information on how to induce acne in an animal by using bacteria as well as chemical. Different in-vitro and in-vivo studies exist to determine several aspects of the drug. In this article, we have focused on all the above topics in brief. INTRODUCTION: Acne is otherwise called as acne vulgaris. It is a chronic inflammatory disease. It occurs on the parts like: face, neck, upper chest, upper back, etc. According to studies, acne is the most prevalent disease in the world. It affects the patient both psychologically as well as psychosocially. The available topical treatments are having few side effects.

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Pearls in the Management of Acne

Cited by 14 publications

References 27 publications

Acne in women

Acne in women

Benzoyl Peroxide, Adapalene, and Their Combination in the Treatment of Acne Vulgaris

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