2015
DOI: 10.1371/journal.pone.0120038
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Pectate Lyase Pollen Allergens: Sensitization Profiles and Cross-Reactivity Pattern

Abstract: BackgroundPollen released by allergenic members of the botanically unrelated families of Asteraceae and Cupressaceae represent potent elicitors of respiratory allergies in regions where these plants are present. As main allergen sources the Asteraceae species ragweed and mugwort, as well as the Cupressaceae species, cypress, mountain cedar, and Japanese cedar have been identified. The major allergens of all species belong to the pectate lyase enzyme family. Thus, we thought to investigate cross-reactivity patt… Show more

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Cited by 49 publications
(44 citation statements)
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“…Art v 1 [25][26][27][28][29][30][31][32][33][34][35][36] -specific TCR tg Jurkat T-cells 25,26 were added and cocultured and IL-2 promoter-driven luciferase activity was determined. 25 Art v 1 [25][26][27][28][29][30][31][32][33][34][35][36] -specific T-cell lines and clones established from mugwort-allergic donors were tested for proliferation in response to the allergens or Art v 1-peptide by 3 H-thymidine uptake. 20…”
Section: T-cell Reactivitymentioning
confidence: 99%
“…Art v 1 [25][26][27][28][29][30][31][32][33][34][35][36] -specific TCR tg Jurkat T-cells 25,26 were added and cocultured and IL-2 promoter-driven luciferase activity was determined. 25 Art v 1 [25][26][27][28][29][30][31][32][33][34][35][36] -specific T-cell lines and clones established from mugwort-allergic donors were tested for proliferation in response to the allergens or Art v 1-peptide by 3 H-thymidine uptake. 20…”
Section: T-cell Reactivitymentioning
confidence: 99%
“…Another study investigating the cross-reactivity between Amb a 1 and homolog pectate lyase allergens from the botanically unrelated Cupressaceae family (Cry j 1, Jun a 1, and Cup a 1) revealed no significant cross-reactivity between these 2 families [18]. …”
Section: Major Ragweed Pollen Allergensmentioning
confidence: 99%
“…The situation in Asia seems to be different than in America and Europe. Although the ragweed plant is also now established in Japan, South Korea, and certain parts of China [1, 18], the sensitization rate seems to be low, at around 5% [18-20]. …”
Section: Introductionmentioning
confidence: 99%
“…Clinically important pollen allergens are found in Ambrosia, Artemisia, Parietaria, Chenopodium album, Kali turgida and Plantago. These can produce up to a million pollen grains per day, which easily spread depending on weather conditions (4) . The "allergic season" for weed pollen usually occurs later than for trees and grasses: as a rule, from midsummer to late autumn (5) .…”
Section: Introductionmentioning
confidence: 99%