Pectin and Galacturonic Acid and the Intestinal Pathogens

Werch, S. C.; Jung, R. W.; Plenk, H.; Day, Alexander A.; Ivy, A. C.

doi:10.1001/archpedi.1942.02010050003001

Cited by 4 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A glass beaker (250 mL) containing 100 mL PBS pH 6.8 was immersed in the flask of the dissolution apparatus with water at 37 ± 0.5°C. After completing the dissolution in 0.1 mol L -1 HCl (2 h) and phosphate buffer, pH 7.4 (3 h), baskets containing the tablets under study were immersed in the PBS medium and the release study was continued for up to 24 h. Samples (5 mL) were withdrawn at different time points (6,8,12 and 24 h), filtered using membrane filters (0.45 mm) and assayed spectrophotometrically for mesalamine at 299 nm in PBS pH 6.8. The same volume of fresh dissolution medium was added to restore the initial volume of the dissolution medium after each sample withdrawal.…”

Section: Methodsmentioning

confidence: 99%

“…A beaker of 250 mL capacity containing 100 mL of PBS (pH 6.8) with rat cecal content was placed suitably in the dissolution vessel having water maintained at 37 ± 0.5°C, which in turn was kept in the water bath of the apparatus. The study was continued from the 6 th h to 24 th h and the samples were withdrawn at different intervals (6,8,12 and 24 h) for analysis and each time replaced with fresh PBS containing rat cecal material bubbled with CO 2 . The withdrawn samples were diluted with PBS and centrifuged.…”

Section: Methodsmentioning

confidence: 99%

“…They are predominantly linear polymers of mainly a-(1-4) linked D-galacturonic acid residues interrupted by 1,2-linked L-rhamnose residues. These polysaccharides remain intact in the physiological environment of the stomach and the small intestine, but are degraded by the bacterial inhabitants of the human colon (6,7). Being soluble in water, pectin is not able to shield its drug load effectively during its passage through the stomach and small intestine.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Box-Behnken experimental design in the development of pectin-compritol ATO 888 compression coated colon targeted drug delivery of mesalamine

Patel¹,

Patel²,

Shah³

2010

Acta Pharmaceutica

View full text Add to dashboard Cite

A novel oral colon-specific drug delivery system (CDDS) has been developed as one of the site-specific drug delivery systems. This delivery system, by means of combining one or more controlled release mechanisms, hardly releases the drug in the upper part of the gastrointestinal (GI) tract, but rapidly releases drug in the colon following oral administration. The necessity and advantage of CDDS have been recognized and reviewed recently (1-3). Owing to CDDS specifically delivering the drug to the colon, many bene- The aim of this study was to investigate the combined influence of 3 independent variables in the compression coated tablet of mesalamine for ulcerative colitis. A 3--factor, 3-level Box-Behnken design was used to derive a second order polynomial equation and construct contour plots to predict responses. The independent variables selected were: percentage of polymers (pectin and compritol ATO 888) in compression coating (X 1 ), coating mass (X 2 ) and coating force (X 3 ). Fifteen batches were prepared and evaluated for percent of drug released in 5 h (Y 5 ), time required for 50 % mesalamine to dissolve (t 50 ) with rat cecal (RC) content and without rat cecal content (t 50 ), percent of drug released in 24 h in the presence of rat cecal content (Y 24 with RC). Transformed values of independent and dependent variables were subjected to multiple regressions to establish a full-model second-order polynomial equation. F was calculated to confirm the omission of insignificant terms from the full-model equation. The computer optimization process and contour plots predicted the levels of independent variables X 1 , X 2 , and X 3 (0, 0.2 and -0.15, respectively) for colon targeting and total percent of drug released up to 24 h.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Box-Behnken experimental design in the development of pectin-compritol ATO 888 compression coated colon targeted drug delivery of mesalamine

Patel¹,

Patel²,

Shah³

2010

Acta Pharmaceutica

View full text Add to dashboard Cite

show abstract

“…During this time, it was observed that prisoners with diarrhoea who ate apples from a nearby orchard experienced a more rapid resolution of their symptoms than those who did not eat apples. Shortly thereafter, it was shown that a raw apple diet improved the symptoms of diarrhoea and dysentery 41, 42 and evidence was provided that the active ingredient in apple that contributed to a reduction in diarrhoea was pectin 43, 44 . The results of many studies that focused on the antidiarrhoeal effects of apples lead to the popular adage ‘an apple a day keeps the doctor away’.…”

Section: Early Diarrhea Managementmentioning

confidence: 99%

Review article: the history of acute infectious diarrhoea management – from poorly focused empiricism to fluid therapy and modern pharmacotherapy

DuPont

2007

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Summary Background Acute diarrhoea management has progressed from largely ineffective measures in the early years to a more effective physiologic approach in recent years. Aim To review the history of acute diarrhoea management. Methods Citations in PubMed were reviewed on ‘acute diarrhoea treatment’ along with an extensive file maintained by the corresponding author. Results Freedom from diarrhoea was equated in early military conflicts with bravery and strength where diarrhoea‐free soldiers had the ‘guts’ to fight. Until early 20th century, colonic irrigants, purgatives and emetic drugs were used to help eliminate undesired intestinal contents. Only a few early authorities suggested the need for replacement of fluids and salt, now standard treatment. Drugs aimed at diarrhoea symptom control have been broadly used for more than 100 years. The evolving history of one of those drugs, kaopectate is unappreciated. Once understanding the pathophysiology and infectious aetiology of acute diarrhoea, new oral fluids, pharmacologic agents designed to block specific secretory alterations and anti‐infective drugs have been identified. Conclusions Physiologic and antimicrobial approaches to controlling diarrhoea can lead to reduction of stool number and enteric complaints, important in industrialized areas, with the potential for decreasing threat of fatal illness among infants in developing regions.

show abstract

Gastroenterology

Jones¹

1942

Arch Intern Med (Chic)

View full text Add to dashboard Cite

Pectin and Galacturonic Acid and the Intestinal Pathogens

Cited by 4 publications

References 6 publications

Box-Behnken experimental design in the development of pectin-compritol ATO 888 compression coated colon targeted drug delivery of mesalamine

Box-Behnken experimental design in the development of pectin-compritol ATO 888 compression coated colon targeted drug delivery of mesalamine

Review article: the history of acute infectious diarrhoea management – from poorly focused empiricism to fluid therapy and modern pharmacotherapy

Gastroenterology

Contact Info

Product

Resources

About