Pectin-based hydrogels with adjustable properties for controlled delivery of nifedipine: development and optimization

Ajaz, Nyla; Khalid, Ikrima; Minhas, Muhammad Usman; Barkat, Kashif; Khan, Ikram Ullah; Syed, Haroon K.; Asghar, Sajid; Munir, Rabia; Aslam, Fahmida

doi:10.1007/s00289-019-03065-7

Cited by 20 publications

(9 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This dynamic chemical bond forms the main body of the crosslinked hydrogel network, which imparts hydrogels with improved mechanical strength and rapid self-healing properties. Pectin forms strong hydrogen bonds with PVA chains, which can further improve the mechanical strength of the hydrogel . The abundant free Na + and B(OH) 4 – ions impart ionic conductivity to hydrogels.…”

Section: Resultsmentioning

confidence: 99%

“…28 Two biopolymers, pectin and tannic acid, were added to the PVA solution to simultaneously ensure the four functionalities. Pectin, an anionic polysaccharide mainly composed of α-(1,4)-D-galacturonic acid, was applied to improve the elastic behavior of the hydrogel matrix, 32 whereas tannic acid, a polyphenolic polymer with catechol groups, was applied to improve interfacial adhesion. 33 After the dissolution of all chemicals at 90 °C, the pH of the solution was adjusted to 8 using NaOH solution (0.1 M), ensuring the formation of borate ester bonds.…”

Section: Design and Mechanism Of Multifunctionalmentioning

confidence: 99%

“…Pectin forms strong hydrogen bonds with PVA chains, which can further improve the mechanical strength of the hydrogel. 32 The abundant free Na + and B(OH) 4 − ions impart ionic conductivity to hydrogels. In addition, the catechol group of tannic acid can dynamically crosslink with B(OH) 4…”

Section: Design and Mechanism Of Multifunctionalmentioning

confidence: 99%

See 2 more Smart Citations

3D Printable Self-Adhesive and Self-Healing Ionotronic Hydrogels for Wearable Healthcare Devices

Seong

Kondaveeti

Choi

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Ionotronic hydrogels have attracted significant attention in emerging fields such as wearable devices, flexible electronics, and energy devices. To date, the design of multifunctional ionotronic hydrogels with strong interfacial adhesion, rapid self-healing, three-dimensional (3D) printing processability, and high conductivity are key requirements for future wearable devices. Herein, we report the rational design and facile synthesis of 3D printable, self-adhesive, self-healing, and conductive ionotronic hydrogels based on the synergistic dual reversible interactions of poly(vinyl alcohol), borax, pectin, and tannic acid. Multifunctional ionotronic hydrogels exhibit strong adhesion to various substrates with different roughness and chemical components, including porcine skin, glass, nitrile gloves, and plastics (normal adhesion strength of 55 kPa on the skin). In addition, the ionotronic hydrogels exhibit intrinsic ionic conductivity imparting strain-sensing properties with a gauge factor of 2.5 up to a wide detection range of approximately 2000%, as well as improved self-healing behavior. Based on these multifunctional properties, we further demonstrate the use of ionotronic hydrogels in the 3D printing process for implementing complex patterns as wearable strain sensors for human motion detection. This study is expected to provide a new avenue for the design of multifunctional ionotronic hydrogels, enabling their potential applications in wearable healthcare devices.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Design and Mechanism Of Multifunctionalmentioning

confidence: 99%

See 1 more Smart Citation

3D Printable Self-Adhesive and Self-Healing Ionotronic Hydrogels for Wearable Healthcare Devices

Seong

Kondaveeti

Choi

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…In all samples, the swelling ratio increased with time. In this context, CMC emerges as a notable weak polyelectrolyte, exhibiting high water absorption and swelling in aqueous media . P–Ca–CMC displayed the highest swelling (283.85 ± 3.21%) among the samples, attributed to the ionization of carboxyl groups at basic pH, leading to network repulsion and subsequent polymer swelling.…”

Section: Resultsmentioning

confidence: 99%

“…In this context, CMC emerges as a notable weak polyelectrolyte, exhibiting high water absorption and swelling in aqueous media. 51 P−Ca− CMC displayed the highest swelling (283.85 ± 3.21%) among the samples, attributed to the ionization of carboxyl groups at basic pH, leading to network repulsion and subsequent polymer swelling. Additionally, the presence of sugars in the patches demonstrated varying effects on the swelling ratios.…”

Section: Dissolving Ability Of Microneedle Patches In Skinmentioning

confidence: 99%

Transdermal Delivery of Catechin Using Dissolving Poly(vinyl alcohol)-Based Microneedles: Effect of Microneedle Composition on Drug Release

Sabbagh,

Saha,

Kim

2023

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

The use of dissolving microneedles presents a highly desirable approach for transdermal drug delivery, offering enhanced patient safety and adherence. This study aimed to assess the release rate of catechin when combined with various constituents in a poly(vinyl alcohol) (PVA) microneedle patch. The impact of incorporating 2% dimethyl sulfoxide (DMSO), 5% carboxymethyl cellulose (CMC), 5% fructose, and 5% sucrose into the PVA microneedle patch was investigated. The manufactured microneedles underwent comprehensive characterization through techniques such as thermogravimetric analysis, scanning electron microscopy, Fourier transform infrared spectroscopy, measurement of thickness, evaluation of antioxidant activity, determination of swelling ratio, assessment of content uniformity, investigation of dissolving capability in skin, analysis of erosion, and release studies. An ex vivo investigation was conducted by using porcine skin and Franz diffusion cells to determine the release rate. The CMC-based microneedle patch displayed the highest catechin release (86.62 ± 4.69%) and swelling ratio (283.85 ± 3.21%). The analyses revealed that sugar enhances the microneedle structure effectively, although it renders the structure brittle and results in lower drug release compared with sugar-free microneedles. Consequently, the CMC-based formulation emerged as the optimal choice for the PVA microneedle patch.

show abstract

pH‐responsive bionanocomposite pectin grafted with dimethylaminoethyl methacrylate and acrylic acid copolymer along with silver nanoparticles for breast cancer drug delivery

Hashem,

Sobh,

Abd El‐Ghaffar

2024

Polymer Engineering & Sci

View full text Add to dashboard Cite

In this study, we developed a pH‐responsive hydrogel membrane composed of pectin, dimethylaminoethyl methacrylate (DMAEMA), and acrylic acid (AA) through a free radical‐triggered graft copolymerization method. Freshly formed silver nanoparticles (AgNPs) produced from the reduction reaction were embedded in the produced hydrogel. Pectin‐grafted dimethylaminoethyl methacrylate and acrylic acid copolymer [poly (DMAEMA‐co‐AA)‐g‐pectin] and its bionanocomposite with AgNPs were confirmed by Fourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The swelling behavior of poly (DMAEMA‐co‐AA)‐g‐pectin in solutions with diverse pH values was assessed. For use as a controlled drug delivery agent, the hydrogel was loaded with 5‐fluorouracil (5‐FU). The incorporation of AgNPs had a great impact on the entrapment efficiency of 5‐FU. At pH 7.4, nearly 48% of the 5‐FU was released in vitro from the polymeric nanocomposite within 24 h. Moreover, poly (DMAEMA‐co‐AA)‐g‐pectin and poly (DMAEMA‐co‐AA)‐g‐pectin/AgNPs presented high cytocompatibility toward normal skin fibroblast cells (BJ1), and the drug delivery system strongly inhibited human Caucasian breast adenocarcinoma cells (MCF‐7). These results demonstrated that these poly (DMAEMA‐co‐AA)‐g‐pectin/AgNPs are an excellent candidate for use in anticancer drug delivery systems.Highlights Free radical polymerization of nanocomposites incorporated with nanoparticles. Nanoparticles improve the bionanocomposites' drug loading. The developed bionanocomposites exhibit control drug release. The novel bionanocomposites acts as an excellent anticancer drug carrier.

show abstract

Pectin-based hydrogels with adjustable properties for controlled delivery of nifedipine: development and optimization

Cited by 20 publications

References 40 publications

3D Printable Self-Adhesive and Self-Healing Ionotronic Hydrogels for Wearable Healthcare Devices

3D Printable Self-Adhesive and Self-Healing Ionotronic Hydrogels for Wearable Healthcare Devices

Transdermal Delivery of Catechin Using Dissolving Poly(vinyl alcohol)-Based Microneedles: Effect of Microneedle Composition on Drug Release

pH‐responsive bionanocomposite pectin grafted with dimethylaminoethyl methacrylate and acrylic acid copolymer along with silver nanoparticles for breast cancer drug delivery

Contact Info

Product

Resources

About