Pectin-Based Scaffolds for Tissue Engineering Applications

Abstract

Tissue engineering (TE) is an interdisciplinary field that was introduced from the necessity of finding alternative approaches to transplantation for the treatment of damaged and diseased organs or tissues. Unlike the conventional procedures, TE aims at inducing the regeneration of injured tissues through the implantation of customized and functional engineered tissues, built on the so-called ‘scaffolds’. These provide structural support to cells and regulate the process of new tissue formation. The properties of the scaffold are essentials, and they can be controlled by varying the biomaterial formulation and the fabrication technology used to its production. Pectin is emerging as an alternative biomaterial to non-degradable and high-cost petroleum-based biopolymers commonly used in this field. It shows several promising properties including biocompatibility, biodegradability, non-toxicity and gelling capability. Pectin-based formulations can be processed through different fabrication approaches into bidimensional and three-dimensional scaffolds. This chapter aims at highlighting the potentiality in using pectin as biomaterial in the field of tissue engineering. The most representative applications of pectin in preparing scaffolds for wound healing and tissue regeneration are discussed.

Impact of Crosslinking on the Characteristics of Pectin Monolith Cryogels

“…These properties, along with the non-toxicity, biodegradability and biocompatibility, make pectin-based materials adequate for a wide range of applications such as agriculture, pharmacy, food and biomedicine. Up to date, pectin-based three-dimensional networks have been investigated for tissue engineering [ 10 ], drug delivery [ 11 ], wound healing [ 12 , 13 ], food technology [ 14 ] and as food packaging material [ 15 ].…”

CytroCell Micronized Cellulose Enhances the Structural and Thermal Properties of IntegroPectin Cross-Linked Films

“…Currently, pectin-based 2D films and 3D structures are widely investigated in tissue engineering for the fabrication of functional scaffolds via bioprinting. 31 The main limitations to widespread utilization of pectin as bio-ink to produce bio-based films and scaffolds are the poor barrier and poor mechanical properties of pectin-based coatings.…”

Advancements and Applications of Electrospray Methods in Skin Tissue Regeneration

“…For instance, the deposition of fibroblasts using ES has shown promising results in maintaining cell viability and function, essential for effective skin regeneration [45,46]. Zheng et al have explored the use of ES for depositing zinc oxide (ZnO) thin films, which are utilized in sensors but have potential applications in skin tissue engineering due to their biocompatibility and microbial resistance [45].…”