Pectin-based systems for colon-specific drug delivery via oral route

Liu, LinShu; Fishman, Marshall L.; Kost, Joseph; Hicks, Kevin B.

doi:10.1016/s0142-9612(03)00213-8

Cited by 480 publications

(285 citation statements)

References 59 publications

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“…Lower drug release at low pH was consistent with studies conducted by previous researchers which concludes that pectin-chitosan combination could decrease drug release in acidic conditions [10][11][12]. Drug release in pH 5.0 medium is shown in fig.…”

Section: Drug Release In Acetic Buffer Ph 50 Phosphate Buffer Ph 6supporting

confidence: 90%

“…Previous research showed that ibuprofen release from hydrogel made from pectin decreases with the use of controlled pH dissolution medium, which indicates that pH controlled drug release has occurred [8]. Other research showed that hydrogel beads of pectin-zein protects indomethacin from upper gastrointestinal tract conditions and its release was controlled by pectin degradation with pectinase; however, pectin is highly soluble in water, which leads to the development of another polymer with low solubility in water, to produce a strong and effective gel for carrying drug which is entrapped in gastric fluid and small intestine [9][10]. One of the polymers that can be used to overcome this problem is chitosan, which its carboxylic group binds ionically with the chitosan amine group [11].…”

Section: Introductionmentioning

confidence: 99%

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Hesperidin Hydrogel Formulation Using Pectin-Chitosan Polymer Combination

Fahrurroji

Thendriani

Riza

2017

Int J Pharm Pharm Sci

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Objective: Hesperidin, a flavonoid glycosides that have been proven to have therapeutic activity to some disease, one of them is colon disease; in addition of its efficacy,low solubility(<100 mg/l) makes hesperidin slightly absorbed,hence it needs a delivery system which could deliver hesperidin to its therapeutic target. This research aims to obtain an optimum formula for pectin polymer combination which can regulate in vitro hesperidin release. Methods:Determination of optimum hydrogel formula uses Design Expert 7.0.0 with factorial method design, resulting in pectin-chitosan concentration formula plan-comparison, which are (P3%: C1%), (P3%: C2%), (P5%: C1%), (P5%: C2%) respectively. Hydrogel was obtained from a variety of formulas,then evaluation of the entrapment efficiency test, swelling index, in vitro drug release test, mucoadhesive strength were conducted.Results: Optimum formula with: pectin: chitosan concentration comparison (5: %: 1%) have an entrapment efficiency of 96.658%; k (/hour) swelling index at pH 5.0, 6.8, and 7.4, was 34.917, 15.766, and 8.146 respectively; drug release at pH 5.0, 6.8, and a medium contained 2% rat caecum was 0.461, 20.116, and the mucoadhesive strength was 0.184 N/cm 2 Conclusion: Combination of pectin-chitosan polymer in hydrogel mucoadhesive regulates hesperidin shesperidin in vitro release, with highest drug release in medium containing 2% rats caecum which releases 56% of active substance. Hesperidin hydrogel release mechanism follows Higuchi kinetics. The optimum hesperidin hydrogel formula is the formula with 5% of pectin and 1% of chitosan. Based on experimental data value which uses simplex lattice design, optimum hesperidin hydrogel formula has insignificant difference between observed and predicted value (p value>0.05).. Based on the test result using independent t-test sample, actual and prediction value from every test parameter produced by the optimum formula was not significantly different with p-value>0,05.

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Section: Drug Release In Acetic Buffer Ph 50 Phosphate Buffer Ph 6supporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Hesperidin Hydrogel Formulation Using Pectin-Chitosan Polymer Combination

Fahrurroji

Thendriani

Riza

2017

Int J Pharm Pharm Sci

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“…Citrus peel is also used in biochemical engineering such as the production of biodegradable plastics by the copolymerization of limonene extracted from Citrus peel and carbon dioxide [5] , but also to produce bio fuels (ethanol) and biogas [6] . Pectin can be extracted from Citrus peel to use it in food industries through its thickening, texturizing, a gelling agent (making jams, jellies, fruit preparations, frozen creams and emulsified products [7] , but also in pharmaceutical industry as an ingredient for preparation of anti-diarrheal and detoxifying drugs [8,9] . Extraction of essential oils remains, actually, the main industrial valorisation of Citrus peel [10,11] .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Efficiency of Different Extraction Methods on Antioxidants of Maltease Orange Peel

Boudhrioua¹

2016

IJFNS

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The effect of conventional solvent extraction, CSE, ultrasound assisted extraction, UAE, microwave assisted extraction, MAE and supercritical CO 2 extraction, SC-CO 2 on the total phenols content, total flavonoids, individual flavonoids and antioxidant activity of orange peel were compared. Neohesperidin (from 0.624 ± 0.013 for SC-CO 2 extraction to 1.045 ± 0.001 g100 g orange peel powder for MAE) and hesperidin (from 0.407 ± 0.008 for SC-CO 2 extraction to 0.836 ± 0.029 g/100 g orange peel powder for UAE) are the major flavonoids (80% of total flavonoids by MAE and 87% by CSE) of orange peel whatever the used extraction method. The method giving the highest total phenol and flavonoid contents is microwave assisted extraction (2.363 ± 0.014 g GAE/100g orange peel powder), followed by ultrasound assisted extraction, conventional solvent extraction, and supercritical CO 2 extraction. However, antioxidant activity (DPPH method) cannot be correlated to TPC, TFC or individual flavonoids. Orange peel extracted by CSE (ethanol (80%), m/v: 5 g:50 ml, 30 min, 35°C, mechanical stirring at darkness, 3 successive extractions) presents the higher radical scavenging capacity compared to the other extracts obtained by MAE (Ethanol (80%), m/v: 5 g: 50 ml, 10s, 35°C, 170 W, 3 successive extractions) and UAE (ethanol (80%), m/v: 5g:50 ml, 30 min, 35°C, magnetic stirring at darkness, 3 successive extractions, 125W), SC-CO 2 extraction (ethanol (80%), m/v:5 g:50 ml, 30 min, 35°C, 22 MPa, 3 successive extractions). Besides, no additivity on the antioxidant activity is found with the DPPH method.

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“…Para além disso, sendo o esvaziamento gástrico a parte mais variável do trânsito gastrointestinal, as formas farmacêuticas revestidas podem ser afetadas por alterações deste trânsito (Liu et al, 2003).…”

Section: Hidróliseunclassified

“…Os sistemas matricias apresentam a vantagem de serem utilizados, em larga escala, pela indústria farmacêutica sem necessidade de recorrer a equipamento muito sofisticado (Liu et al, 2003). Apesar disso, a elevada hidrofilia dos polissacarídeos representa, sobretudo nestes sistemas, uma grande limitação, pelo que a sua utilização restringe-se a fármacos pouco solúveis.…”

Section: Hidróliseunclassified