Pectin-derived oligogalacturonic acids ameliorate high-fat diet-induced obesity in mice by regulating gut microbiota and inflammation

Li, Qian; Wang, Man; Zhang, Yue; Li, Yubing; Zhang, Xianfen; Li, Haowei; Peng, Ying; Zhu, Changlian; Zheng, Pengyuan; Yang, Shaolong; Li, Jiang; Lin, Jiafu; He, Rong; Zhang, Hongmei; Zhou, Huoxiang

doi:10.1016/j.jff.2023.105928

Cited by 5 publications

(1 citation statement)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Short chain fatty acids, a type of fatty acid with fewer than six carbon atoms, are produced by gut bacteria when they ferment fiber, and they exert several effects on the host's metabolism and immune system [22]. In the present study, we found that the concentrations of total SCFAs, acetate, propionate, and butyrate were lower in the RPF group than in the CON group, which is in agreement with a previous study on mice [23]. Acetate and butyrate are mainly generated by fiber.…”

Section: Effects Of Dietary Rumen-protected Fat On Fecal Short-chain ...supporting

confidence: 93%

The Changes in Fecal Bacterial Communities in Goats Offered Rumen-Protected Fat

Liu,

Peng,

Mao

et al. 2024

Microorganisms

View full text Add to dashboard Cite

Leizhou goats are famous for their delicious meat but have inferior growth performance. There is little information on rumen-protected fat (RPF) from the Leizhou goat. Hence, we observed the effects of RPF on growth, fecal short-chain fatty acids, and bacteria community with respect to Leizhou goats. Twelve goats (13.34 ± 0.024 kg) were selected and assigned randomly to one of two treatments: (1) a control diet (CON) and (2) 2.4% RPF with a control diet (RPF). The final body weight and average daily gain (ADG) were greater (p < 0.05), and the dry matter intake (DMI): ADG was lower (p < 0.05) in the RPF group than in the CON group. There were no differences in DMI between the CON and RPF groups. The concentrations of total short-chain fatty acids, acetate, propionate, and butyrate were lower (p < 0.05) in the RPF group than in the CON group. The relative abundances of Ruminococcus, Rikenellaceae_RC9_gut_group, Treponema, norank_f__norank_o__RF39, Eubacterium_siraeum_group, and Ruminococcus_torques_group were lower (p < 0.05) in the RPF group than in the CON group. The relative abundances of Bacteroides, norank_f__norank_o__Clostridia_UCG-014, norank_f__Eubacterium_coprostanoligenes_group, Eubacterium_ruminantium_group, norank_f__Oscillospirale-UCG-010, Oscillospiraceae_UCG-002, and Family_XIII_AD3011_group were greater (p < 0.05) in the RPF group than in the CON group. It was concluded that RPF could improve the goats’ growth performance by regulating their fecal bacteria communities.

show abstract

Section: Effects Of Dietary Rumen-protected Fat On Fecal Short-chain ...supporting

confidence: 93%

The Changes in Fecal Bacterial Communities in Goats Offered Rumen-Protected Fat

Liu,

Peng,

Mao

et al. 2024

Microorganisms

View full text Add to dashboard Cite

show abstract

Comparative effects of different dietary pectin types on growth performance and intestinal health in pearl gentian grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂)

Zhu,

Meng,

Wang

et al. 2025

Aquaculture Reports

View full text Add to dashboard Cite

Preventive role of Pastinaca sativa in mitigating metabolic dysfunction- associated steatotic liver disease via modulation of metabolic endotoxemia

Park,

Lee,

Lee

et al. 2024

Preprint

View full text Add to dashboard Cite

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver disorders worldwide. Parsnip (Pastinaca sativa) has been utilized in food and medicine for centuries, owing to its high content of dietary fiber and various pharmacological properties. Although the health benefits of this root vegetable have been reported, its anti- MASLD effects remain largely understudied. Therefore, this study aimed to evaluate the prebiotic effects of a parsnip root water-soluble extract (PRE) and its alleviatory effects against MASLD and metabolic endotoxemia in a mouse model. Mice were fed a high-fat diet supplemented with 50 and 100 mg/kg of PRE for eight weeks. Mice administered with PRE exhibited reduced fat accumulation and serum metabolic changes that were associated with liver injury. Furthermore, PRE treatment reduced the hepatic lipogenic protein levels that were elevated by the high-fat diet. This extract improved intestinal barrier function by modulating endotoxin, intestinal permeability, and tight junction protein expression. This confirms that PRE is associated with improved gut health. These findings suggest that oral administration of PRE may prevent MASLD and improve metabolic health, which can facilitate the use of this extract as a dietary supplement.

show abstract

Pectin-derived oligogalacturonic acids ameliorate high-fat diet-induced obesity in mice by regulating gut microbiota and inflammation

Cited by 5 publications

References 60 publications

The Changes in Fecal Bacterial Communities in Goats Offered Rumen-Protected Fat

The Changes in Fecal Bacterial Communities in Goats Offered Rumen-Protected Fat

Comparative effects of different dietary pectin types on growth performance and intestinal health in pearl gentian grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂)

Preventive role of Pastinaca sativa in mitigating metabolic dysfunction- associated steatotic liver disease via modulation of metabolic endotoxemia

Contact Info

Product

Resources

About