Pectin fromPassiflora edulisShows Anti-inflammatory Action as well as Hypoglycemic and Hypotriglyceridemic Properties in Diabetic Rats

Abstract

Flour made from Passiflora edulis fruit peel has been used in Brazil to treat diabetes. This study evaluated the effects of pectin from P. edulis on rats with alloxan-induced diabetes, on myeloperoxidase release from human neutrophils, and on carrageenan-induced paw edema. In the experiments on carrageenan-induced paw edema, paws were dissected for hematoxylin-eosin staining and immunohistochemistry determinations of tumor necrosis factor-α and inducible nitric oxide synthase. Male Wistar rats were divided into the following groups: diabetic controls and diabetic treated with pectin daily for 5 days (0.5-25 mg/kg orally). Glibenclamide and metformin were used as reference drugs. Forty-eight hours after alloxan administration, blood measures were determined (before treatment) and again 5 days later (after treatment). Pectin decreased blood glucose and triglyceride levels in diabetic rats. Pectin also decreased edema volume and release of myeloperoxidase (0.1-100 μg/mL). It also significantly decreased neutrophil infiltration and partially decreased immunostaining for tumor necrosis factor-α and inducible nitric oxide synthase. In conclusion, these data indicated that pectin, a bioactive compound present in P. edulis, has potential as a useful alternative treatment for type 2 diabetes. Its anti-inflammatory properties are probably involved in its antidiabetic action.

Capacidade antioxidante e composição química da casca de maracujá (Passiflora edulis)

“…Além disso, estudo com modelo experimental demonstrou efeito anti-infl amatório, com diminuição do volume do edema, liberação de mieloperoxidase, infi ltração de neutrófi los e da expressão de TNF- e iNOS (SILVA et al, 2011).…”

Low‐methoxyl lemon pectin attenuates inflammatory responses and improves intestinal barrier integrity in caerulein‐induced experimental acute pancreatitis

“…Earlier studies on dietary pectins have been functionally described for their nutritional, antioxidant, antiapoptotic, anticancer, and antidiabetic properties . Supplementation of pectins varies from 1 day up to weeks in vivo .…”

Effect of vegetal-oil emulsion and passion fruit peel-powder on sensory acceptance of functional yogurt

“…Even though there are some studies showing the individual effect of Fabuless and passion fruit peel-fibres, respectively, in suppressing appetite as well as in anti-diabetic and in the prevention of dyslipidaemia (Burns et al, 2001;Barbalho et al, 2011;Gupta et al, 2011;Silva et al, 2011), scarce literature is available concerning its simultaneous influence on firmness and sensory properties when added to dairy products.…”