Pectin in cancer therapy: A review

Zhang, Wenbo; Xu, Ping; Zhang, Han

doi:10.1016/j.tifs.2015.04.001

Cited by 202 publications

(132 citation statements)

References 121 publications

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“…Endocytosis of modified pectin into liver cells occurs via asialoglycoprotein receptors. Hydrophilic modified pectin can move across cell membrane barrier only through intervention of active transporter (Zhang et al, 2015).…”

Section: Mechanism Of Absorption Of Pectin In Vivomentioning

confidence: 99%

“…Biologically active portions in pectin are enriched under conditions which favour β-elimination such as acid hydrolysis, alkali treatment at 50 to 60°C. Elimination reaction reduces the length of pectin backbone, that is, induces depolymerisation, lowers DE through deesterification of HG regions, preferentially removes arabinose residues and ultimately results in improved solubility (Leclere et al, 2013;Zhang et al, 2015). Enzymatic modification of pectin has been brought about by endo-polygalacturonase (Endo-PG) which results in highly selective and specific structural changes in the polymer backbone.…”

Section: Modification Of Pectinmentioning

confidence: 99%

“…It has been shown that active fragments are low molecular weight (10 to 20 kDa) oligosaccharides (Jackson et al, 2007). Programmed cell death of tumor cells via cell detachment from its matrix or tumor cell anoikis is another probable mechanism of antitumor effects of modified pectin (Zhang et al, 2015).…”

Section: Effect Of Modified Pectin On Cancersmentioning

confidence: 99%

“…Similarly, growth of breast (MDA-MB-435) and colon (LSLiM6) tumors implanted in NRC nu/nu mice was halted by MCP with decline in the number of metastases in lungs and lymph nodes. Balb/C mice fed on daily oral dose of MCP showed reduction in size of colon tumors (Leclere et al, 2013;Zhang et al, 2015).…”

Section: Effect Of Modified Pectin On Cancersmentioning

confidence: 99%

“…Re-sensitization of cancer cells to different cytotoxic agents such as doxorubicin, cisplatin, bortezomide and dexamethasone have been reported after administration of GCS-100, commercial form of MCP during investigations on multiple myeloma cells and prostate cancer cells (Leclere et al, 2013). Modified pectin can function as biological response modifier and can be involved in regulation of immunological system (Zhang et al, 2015).…”

Section: Effect Of Modified Pectin On Cancersmentioning

confidence: 99%

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Therapeutic and pharmaceutical benefits of native and modified plant pectin

Majee¹,

Avlani²,

Biswas³

2018

J. Med. Plants Res.

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Plant pectin constitutes an important class of naturally occurring polysaccharides and are widely distributed in various fruits and vegetables consumed on a regular basis. These biomolecules are reported to exhibit a vast array of biological activities including effects on digestive system, chemopreventive effect in colon cancer, regulation of blood cholesterol level and immune-potentiating effects. However, variation in spectrum of activity and efficacy occurs due to different sources of pectin and also different methods of extraction. Pectin modification by pH treatment, change in temperature or enzymatic modification methods can ensure derivatives with variable but defined degrees of esterification, customized physicochemical properties and improved pharmacological and therapeutic profile, mainly in cancer prevention and management. Pharmaceutical utility of plant pectin is attributed to the unique rheological behavior and gelling properties in aqueous medium and have been successfully employed in development of colon specific sustained release drug delivery systems and edible pectin films with stabilizing effect on entrapped labile molecules. The goal of the review article is to focus on the therapeutic and pharmaceutical benefits of native and modified pectin. Although, several milestones towards understanding the process of pectin modification have been established, most of the data generated till date are obtained from in vitro studies or on commercial varieties of modified pectin. Complete characterization of structure-activity relationships of modified pectin, wellplanned in vivo investigations and optimization of pectin-based scaffolds for controlled and targeted drug delivery in oncotherapy are yet to be ascertained for enhancing the marketing potential of these renewable plant-derived biopolymers.

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Section: Mechanism Of Absorption Of Pectin In Vivomentioning

confidence: 99%

Section: Modification Of Pectinmentioning

confidence: 99%

Section: Effect Of Modified Pectin On Cancersmentioning

confidence: 99%

Section: Effect Of Modified Pectin On Cancersmentioning

confidence: 99%

Section: Effect Of Modified Pectin On Cancersmentioning

confidence: 99%

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Therapeutic and pharmaceutical benefits of native and modified plant pectin

Majee¹,

Avlani²,

Biswas³

2018

J. Med. Plants Res.

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Pectin as a Rheology Modifier: Chemistry, Production, and Rheology

Chan

Choo

Young

et al. 2020

Materials Science and Technology

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Pectin is a diverse family of polysaccharides with an anionic backbone of α‐1,4‐linked d ‐galacturonic acid (GalA) units. It has been widely used as an emulsifier, gelling agent, glazing agent, stabilizer, and thickener in food, pharmaceutical, personal care, and polymer applications. Commercial pectin is obtained through acid extraction from food waste such as apple pomace, citrus peel, and to a lesser extent, sugar beet pulp. Commercial pectin is classified according to degree of methylation (DM): high methoxy pectin (HMP) with DM > 50% and low methoxy pectin (LMP) with DM < 50%. In general, pectin solution exhibits Newtonian behavior at low shear rate and pseudoplastic behavior when the shear rate is increased. The pseudoplastic behavior of pectin solution is more pronounced with higher pectin concentration. HMP gels in the presence of co‐solute in acidic medium through hydrogen bonding and hydrophobic interactions. Alternatively, LMP gels in the presence of cation over a wide range of pH through ionic linkages, famously known as the “egg‐box” model. This review provides an overview of the chemistry, production, and rheology of pectin. In addition, the effect of modification and processing on the physicochemical properties of pectin and the application of pectin as a rheology modifier are discussed.

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Pectin‐Based Biocomposite Materials for Biomedical and Cosmetic Applications

Biswal

2024

Biopolymers in Pharmaceutical and Food Applications

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Pectin in cancer therapy: A review

Cited by 202 publications

References 121 publications

Therapeutic and pharmaceutical benefits of native and modified plant pectin

Therapeutic and pharmaceutical benefits of native and modified plant pectin

Pectin as a Rheology Modifier: Chemistry, Production, and Rheology

Pectin‐Based Biocomposite Materials for Biomedical and Cosmetic Applications

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