Pectin nanocoating of titanium implant surfaces ‐ an experimental study in rabbits

Gurzawska, Katarzyna; Dirscherl, Kai; Jørgensen, Bodil; Berglundh, Tord; Jørgensen, Niklas Rye; Gotfredsen, Klaus

doi:10.1111/clr.12798

Cited by 14 publications

(13 citation statements)

References 60 publications

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“…Each animal received two implants of the same kind of material and same treatment. We did not detect histological differences between both legs despite of temporal difference, in a similar way as other authors …”

Section: Methodssupporting

confidence: 91%

“…We did not detect histological differences between both legs despite of temporal difference, in a similar way as other authors. 20,21 All animals received postoperative analgesia consisting of 200 μl of subcutaneous meloxicam over the first 5 days; following this, analgesia was administered based on a daily assessment of pain. We assessed pain-stress and the temperature and weight of each animal every 24 h on weekdays to ensure the physical status.…”

Section: Sample Preparationmentioning

confidence: 99%

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Staphylococcus aureus Prosthetic Joint Infection Is Prevented by a Fluorine‐ and Phosphorus‐Doped Nanostructured Ti–6Al–4V Alloy Loaded With Gentamicin and Vancomycin

Auñón

Esteban

Doadrio

et al. 2019

Journal Orthopaedic Research

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Prosthetic joint infection (PJI) is one of the most devastating complications in orthopedic surgery. One approach used to prevent PJI is local antibiotic therapy. This study evaluates the antibiotic release, in vitro cytocompatibility and in vivo effectiveness in preventing PJI caused by Staphylococcus aureus (S. aureus) of the fluorine‐ and phosphorus‐doped, bottle‐shaped, nanostructured (bNT) Ti–6Al–4V alloy loaded with a mixture of gentamicin and vancomycin (GV). We evaluated bNT Ti–6Al–4V loading with a mixture of GV, measuring the release of these antibiotics using high‐performance liquid chromatography. Further, we describe bNT Ti–6Al–4V GV cytocompatibility and its efficacy against S. aureus using an in vivo rabbit model. GV was released from bNT Ti–6Al–4V following a Boltzmann non‐linear model and maximum release values were obtained at 240 min for both antibiotics. The cell proliferation of MCT3T3‐E1 osteoblastic cells significantly increased at 48 (28%) and 168 h (68%), as did the matrix mineralization (52%) of these cells and the gene expression of three of the most important markers related to bone differentiation (more than threefold for VEGF and BGLAP, and 65% for RunX) on bNT Ti–6Al–4V GV compared with control. In vivo study results show that bNT Ti–6Al–4V GV can prevent S. aureus PJI according to histopathological and microbiological results. According to our results, bNT Ti–6Al–4V loaded with a mixture of GV using the soaking method is a promising biomaterial with favorable cytocompatibility and osteointegration, demonstrating local bactericidal properties against S. aureus. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:588–597, 2020

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Section: Methodssupporting

confidence: 91%

Section: Sample Preparationmentioning

confidence: 99%

Staphylococcus aureus Prosthetic Joint Infection Is Prevented by a Fluorine‐ and Phosphorus‐Doped Nanostructured Ti–6Al–4V Alloy Loaded With Gentamicin and Vancomycin

Auñón

Esteban

Doadrio

et al. 2019

Journal Orthopaedic Research

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“…Nanocomposite coatings have also been used on dental implants to manipulate materials’ mechanical properties to better match natural bone [ 139 ]. Various nanoparticles, including but not limited to titanium dioxide (TiO 2 ), silver (Ag), hydroxyapatite (HA), pectins, cubic zirconia, ultra-nanocrystalline diamond, carbon nanotube, can be added to titanium using both physical and chemical techniques [ 139 , 140 , 141 , 142 , 143 ]. Typical physical methods include nanoparticle compaction, plasma spraying deposition, physical vapor deposition, and hot isostatic pressing [ 57 ].…”

Section: Titanium Implantsmentioning

confidence: 99%

The Impact of Dental Implant Surface Modifications on Osseointegration and Biofilm Formation

Kligman

Ren

Chung

et al. 2021

JCM

188

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Implant surface design has evolved to meet oral rehabilitation challenges in both healthy and compromised bone. For example, to conquer the most common dental implant-related complications, peri-implantitis, and subsequent implant loss, implant surfaces have been modified to introduce desired properties to a dental implant and thus increase the implant success rate and expand their indications. Until now, a diversity of implant surface modifications, including different physical, chemical, and biological techniques, have been applied to a broad range of materials, such as titanium, zirconia, and polyether ether ketone, to achieve these goals. Ideal modifications enhance the interaction between the implant’s surface and its surrounding bone which will facilitate osseointegration while minimizing the bacterial colonization to reduce the risk of biofilm formation. This review article aims to comprehensively discuss currently available implant surface modifications commonly used in implantology in terms of their impact on osseointegration and biofilm formation, which is critical for clinicians to choose the most suitable materials to improve the success and survival of implantation.

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“…No differences were detected between both legs despite the temporal difference, in a similar way to other authors. 21,37…”

Section: Methodsmentioning

confidence: 99%

Urine Aluminum Concentration as a Possible Implant Biomarker of Pseudomonas aeruginosa Infection Using a Fluorine- and Phosphorus-Doped Ti-6Al-4V Alloy with Osseointegration Capacity

et al. 2019

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Joint prosthesis failure is mainly related to aseptic loosening and prosthetic joint infections, both associated with high morbidity and a substantial cost burden for patients and health systems. The development of a biomaterial capable of stimulating bone growth while minimizing bacterial adhesion would reduce the incidence of prosthetic failure. Using an in vivo rabbit model, this study evaluates the osseointegration effect of the fluorine (F)- and phosphorus (P)-doped bottle-shaped nanostructured (bNT) Ti-6Al-4V alloy and effectiveness of monitoring urine aluminum concentration to determine the presence of Pseudomonas aeruginosa infection in Ti-6Al-4V implants. Unlike chemically polished (CP) Ti-6Al-4V alloy implants, bNT Ti-6Al-4V alloy implants promoted osseointegration and showed effectiveness as a biomaterial marker. The bNT Ti-6Al-4V alloy implants were associated with a twofold increase in bone thickness and up to 15% greater bone density compared to the CP alloy. Additionally, bNT Ti-6Al-4V alloy implants allowed for discrimination between P. aeruginosa -infected and noninfected animals for 15 days postoperatively, as indicated by the decrease of aluminum concentration in urine, while this difference was only appreciable over the first 7 days when CP Ti-6Al-4V alloy implants were used. Therefore, bNT Ti-6Al-4V alloys could have clinical applications by detecting the infection and by avoiding aseptic loosening.

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Pectin nanocoating of titanium implant surfaces ‐ an experimental study in rabbits

Abstract: The present study showed that nanocoating of titanium implants with pectin RG-Is did not significantly enhance bone healing and osseointegration when placed in rabbit tibia bone.

Cited by 14 publications

References 60 publications

Staphylococcus aureus Prosthetic Joint Infection Is Prevented by a Fluorine‐ and Phosphorus‐Doped Nanostructured Ti–6Al–4V Alloy Loaded With Gentamicin and Vancomycin

Staphylococcus aureus Prosthetic Joint Infection Is Prevented by a Fluorine‐ and Phosphorus‐Doped Nanostructured Ti–6Al–4V Alloy Loaded With Gentamicin and Vancomycin

The Impact of Dental Implant Surface Modifications on Osseointegration and Biofilm Formation

Urine Aluminum Concentration as a Possible Implant Biomarker of Pseudomonas aeruginosa Infection Using a Fluorine- and Phosphorus-Doped Ti-6Al-4V Alloy with Osseointegration Capacity

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