Pectin shows antibacterial activity against &amp;lt;i&amp;gt;Helicobacter pylori&amp;lt;/i&amp;gt;

Daoud, Ziad; Sura, Mihir; Abdel-Massih, Roula M.

doi:10.4236/abb.2013.42a037

Cited by 15 publications

(15 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies that involved evaluating functionalities of different oligosaccharides showed the tremendous potential of oligosaccharides in various aspects related to health and disease. Functional oligosaccharides have been found effective in gastrointestinal normal flora proliferation and pathogen suppression, dental caries prevention, enhancement of immunity, facilitation of mineral absorption, source of antioxidant, antibiotic alternative, regulators of blood glucose in diabetics, and serum lipids in hyperlipidemics [7]. Xylooligosaccharides in pharmaceutical preparations exhibit antiallergy, antimicrobial, anti-infection, and anti-inflammatory properties, selective cytotoxicity, and immunomodulatory action [10].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In Vitro and In Vivo Anti-Salmonella Evaluation of Pectin Extracts and Hydrolysates from “Cas Mango” (Spondias dulcis)

Zofou

Shu

Foba-Tendo

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. The threat to human health posed by multidrug-resistant strains of Salmonella typhi (S. typhi) and Salmonella paratyphi (S. paratyphi) is of growing concern. Generally, there has been increasing resistance and even multidrug resistance to almost all classes of antibiotics. This has rendered treatment with antibiotics difficult and costly. The present study investigated the bioactivity of pectin and pectin hydrolysates derived from a local fruit, Spondias dulcis, against four strains of Salmonellae. Methods. Pectin was extracted from alcohol extractives-free peel by acidic hydrolysis at a temperature of 80°C for one hour at pH 2 and 4. The pectin was precipitated with 95% alcohol at an extract to alcohol ratio of 1:10 v/v. Antimicrobial activity was determined using agar well diffusion technique. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were determined using the broth dilution technique. An in vivo study was then carried out with the bioactive extracts against the most resistant bacteria strain, to fully establish the therapeutic effect of these extracts. Balb/C mice were used, and ciprofloxacin was the positive control antibiotic. The extracts were administered to mice at two doses, 5mg/Kg and 10mg/Kg. The efficacy of extracts in the treatment of typhoid was evaluated based on survival rate, change in body weight, and change in bacteria load. Results. Only one of the extracts (crude pectin pH 2.5) was active against all the Salmonellae by well diffusion, and the growth inhibition varied from 12mm to 15mm at100 μg/ml. Three of the extracts (crude pectin pH 2.5, pH 4, 12h hydrolysate, and pH 4, 1h hydrolysate) had MIC and MBC against all four Salmonellae strains with MIC ranging from 5.68 to 44.45 μg/ml and MBC from 11.36 to 44.45 μg/mL. Three treatments, namely, the pH4-12 hr, hydrolysate at 10mg/Kg and 5mg/Kg, and the pH4-1hr, hydrolysate at 10mg/Kg, had therapeutic effects against Salmonella infection in mice. Conclusion. The present study highlights the potential of pectin oligosaccharides as new source of anti-Salmonella drugs. Further investigations including exploration of mechanism of action of the most active pectin extracts/hydrolysates are envisaged.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Pectins are found to have antimicrobial potential against the methicillin resistant Staphylococcus aureus and Aspergillus niger [6]. Pectin also showed antibacterial activity against Helicobacter pylori [7].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Anti-Salmonella Evaluation of Pectin Extracts and Hydrolysates from “Cas Mango” (Spondias dulcis)

Zofou

Shu

Foba-Tendo

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…In 2013, scholars in Lebanon reported the significant antibacterial activity of citrus pectin against all 16 clinical isolates and 2 reference strains of Gram-negative Helicobacter pylori, a common human pathogen and public health problem that causes gastritis and peptic ulcers. [20] Once again, the highest antibacterial activity was observed at pH 5.0 and lower activity at higher pH values, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL and minimum bactericidal concentration (MBC) of 0.325 mg/mL. Two years later, the same team reported that optimal antibacterial activity against S. aureus and E. coli was observed at pH 6, with MIC values against S. aureus ranging between 0.39 mg/mL and 3.125 mg/mL and minimum bactericidal concentration (MBC) varying in the ample range 3.125-12.5 mg/ mL.…”

Section: A Broad-spectrum Antimicrobialmentioning

confidence: 99%

“…Not only is pectin a broad-spectrum antimicrobial agent whose in vitro [1,5,6,7,12,19,20] and in vivo [14,15,16] activity has long been established in thorough laboratory and clinical trials, but low methoxyl pectin is also a biomaterial whose exceptional biocompatible nature and superior rheological properties make it ideally suited as an injectable cell vehicle for bone tissue regeneration. [26] In the latter case, a low degree of esterification is required because the galacturonic acid groups are functionalized with an RGD-containing oligopeptide (RGD, Arg-Gly-Asp).…”

Section: A Broad-spectrum Antimicrobialmentioning

confidence: 99%

Pectin: A Long‐Neglected Broad‐Spectrum Antibacterial

Ciriminna

Fidalgo

Meneguzzo³

et al. 2020

ChemMedChem

View full text Add to dashboard Cite

This article is dedicated to Professor Mohamed A. el-Nakeeb (University of Alexandria, Egypt) for his pioneering research on the antimicrobial activity of pectin First reported in the late 1930s and partly explained in 1970, the antibacterial activity of pectin remained almost ignored until the late 1990s. The concomitant emergence of research on natural antibacterials and new usages of pectin polysaccharides, including those in medicine widely researched in Russia, has led to a renaissance of research into the physiological properties of this uniquely versatile polysaccharide ubiquitous in plants and fruits. By collecting scattered information, this study provides an updated overview of the subtle factors affecting the behaviour of pectin as an antimicrobial. Less-degraded pectin extracted by acid-free routes, we argue in the conclusions, will soon find applications from new treatments for polymicrobial infections to use as an implantable biomaterial in tissue and bone engineering.

show abstract

“…Polysaccharides from natural sources, including fucoidans, may have a direct bactericidal influence on various microorganisms. Thus, the bactericidal action of citrus pectin, which is a branched, high molecular weight polysaccharide found in the cell walls of higher plants, against H. pylori has been described in the literature . The bactericidal effect of pectin was established for 16 clinical and two reference strains of the causative agent.…”

Section: The Direct Bactericidal Effect Of Sulfated Polysaccharidesmentioning

confidence: 99%

Review: Prospects for the Use of Extracts and Polysaccharides from Marine Algae to Prevent and Treat the Diseases Caused by Helicobacter pylori

Беседнова¹,

Ts²,

Сомова³

et al. 2015

Helicobacter

View full text Add to dashboard Cite

Helicobacter pylori possesses a broad spectrum of pathogenic factors that allow it to survive and colonize the gastric mucosa, and thus, the pathogenetic targets, which have the same diversity, require search for and the development of alternative, effective, and innocuous means for the eradication of H. pylori. In recent years, fucoidans have been extensively studied due to the numerous interesting biological activities, including the anti-adhesive, anti-oxidative, antitoxic, immunomodulatory, anticoagulant, and anti-infection effects. This review summarizes the data on the effects of extracts and sulfated polysaccharides of marine algae, mainly fucoidans, on pathogenic targets in Helicobacter infection. The pathogenetic targets for therapeutic agents after H. pylori infection, such as flagellas, urease, and other enzymes, including adhesins, cytotoxin A (VacA), phospholipase, and L-8, are characterized here. The main target for the sulfated polysaccharides of seaweed is cell receptors of the gastric mucosa. This review presents the published data about the pleiotropic anti-inflammatory effects of polysaccharides on the gastric mucosa. It is known that fucoidan and other sulfated polysaccharides from algae have anti-ulcer effects, prevent the adhesion of H. pylori to, and reduce the formation of biofilm. The authors speculate that the effect of sulfated polysaccharides on the infectious process caused by H. pylori is related to their action on innate and adaptive immunity cells, and also anti-oxidant and antitoxic potential. Presented in the review are materials indicated for the study of extracts and sulfated polysaccharides from seaweed during H. pylori infection, as these compounds are characterized by multimodality actions. Based on the analysis of literary materials in recent years, the authors concluded that fucoidan can be attributed to the generation of new candidates to create drugs intended for the inclusion in the scheme of eradication therapy of H. pylori infection.

show abstract

Pectin shows antibacterial activity against <i>Helicobacter pylori</i>

Cited by 15 publications

References 20 publications

In Vitro and In Vivo Anti-Salmonella Evaluation of Pectin Extracts and Hydrolysates from “Cas Mango” (Spondias dulcis)

In Vitro and In Vivo Anti-Salmonella Evaluation of Pectin Extracts and Hydrolysates from “Cas Mango” (Spondias dulcis)

Pectin: A Long‐Neglected Broad‐Spectrum Antibacterial

Review: Prospects for the Use of Extracts and Polysaccharides from Marine Algae to Prevent and Treat the Diseases Caused by Helicobacter pylori

Contact Info

Product

Resources

About