Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway

Xu, Fei; Gao, Xuan; Pan, Hong

doi:10.3892/or.2018.6759

Cited by 15 publications

(16 citation statements)

References 35 publications

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“…Pectolinarigenin was shown to be active against different cancer cell lines [37][38][39][40][41]. To date and to our knowledge, only one study described its anticancer potential on RCC cells (ACHN) with an IC 50 value of 15.2 µM [42].…”

Section: Subfractions Compound Code T R (Min) λMax (Nm) [M-h]mentioning

confidence: 99%

“…To date and to our knowledge, only one study described its anticancer potential on RCC cells (ACHN) with an IC 50 value of 15.2 µM [42]. The effects of pectolinarigenin on the viability of SK-HEP-1, SMMC-7721 and PLC5 liver cancer cells were also reported (IC 50 values of 10, 11.59 and 11.97 µM, respectively) [39][40][41] as well as on A549 and Calu-3 lung cancer cells (IC 50 values of 21.49 and 22.63 µM, respectively) [40], SW620 colon cancer cells (IC 50 = 13.05 µM) and KATO-III, AGS and MKN28 gastric cancer cells (IC 50 of 24.31, 124.79 and 96.88 µM, respectively) [37,38].…”

Section: Subfractions Compound Code T R (Min) λMax (Nm) [M-h]mentioning

confidence: 99%

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Selective Cytotoxicity of Portuguese Propolis Ethyl Acetate Fraction towards Renal Cancer Cells

et al. 2022

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Renal cell carcinoma is the most lethal cancer of the urological system due to late diagnosis and treatment resistance. Propolis, a beehive product, is a valuable natural source of compounds with bioactivities and may be a beneficial addition to current anticancer treatments. A Portuguese propolis sample, its fractions (n-hexane, ethyl acetate, n-butanol and water) and three subfractions (P1–P3), were tested for their toxicity on A498, 786-O and Caki-2 renal cell carcinoma cell lines and the non-neoplastic HK2 kidney cells. The ethyl acetate fraction showed the strongest toxicity against A498 (IC50 = 0.162 µg mL−1) and 786-O (IC50 = 0.271 µg mL−1) cells. With similar toxicity against 786-O, P1 (IC50 = 3.8 µg mL−1) and P3 (IC50 = 3.1 µg mL−1) exhibited greater effect when combined (IC50 = 2.5 µg mL−1). Results support the potential of propolis and its constituents as promising coadjuvants in renal cell carcinoma treatment.

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Section: Subfractions Compound Code T R (Min) λMax (Nm) [M-h]mentioning

confidence: 99%

Section: Subfractions Compound Code T R (Min) λMax (Nm) [M-h]mentioning

confidence: 99%

Selective Cytotoxicity of Portuguese Propolis Ethyl Acetate Fraction towards Renal Cancer Cells

et al. 2022

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“…Phosphatase and tensin homolog (PTEN) has been appreciated as an important tumor suppressor and to oppose phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway in human cancers [12]. Accruing works have revealed that PTEN is involved in progression of cancers and negatively correlated with AKT signaling in hypopharyngeal carcinoma, non-small cell lung cancer and esophageal squamous cell carcinoma [13][14][15]. Previous study suggested that loss of PTEN is associated with progression of papillary thyroid cancer [16].…”

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confidence: 99%

miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN

Shi¹,

Liu²,

Li³

et al. 2020

neo

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Thyroid cancer is one common endocrine malignancy with various pathological types. MicroRNAs (miRNAs) play essential roles in development, prognosis and treatment of thyroid cancer. However, the role of miR-17-5p in thyroid cancer progression and its mechanism remain poorly understood. The expressions of miR-17-5p and phosphatase and tensin homolog (PTEN) were measured in thyroid cancer tissues and cells by quantitative real-time polymerase chain reaction or western blot. Cell proliferation and apoptosis were detected by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay and flow cytometry, respectively. The protein levels of biomarkers in autophagy or protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) pathway were analyzed by western blot. The interaction between miR-17-5p and PTEN was probed by luciferase activity assay. We found that miR-17-5p expression was elevated and PTEN level was reduced in thyroid cancer tissues and cells compared with their corresponding controls. Knockdown of miR-17-5p or overexpression of PTEN suppressed cell proliferation and autophagy but promoted apoptosis in thyroid cancer cells. PTEN was indicated as a target of miR-17-5p and its interference reversed abrogation of miR-17-5p-mediated inhibition of proliferation and autophagy and increase of apoptosis. Moreover, downregulation of miR-17-5p impeded the activation of AKT/mTOR pathway in thyroid cancer cells, which was attenuated by silencing PTEN. Our data supported that knockdown of miR-17-5p upregulated PTEN expression, therefore leading to suppression of the malignancy of thyroid cancer and inactivation of AKT/mTOR pathway, providing a novel avenue for treatment of thyroid cancer.

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“…As a typical candidate, flavonoids have exhibited potential for cancer suppression through apoptosis induction and other different mechanisms, such as autophagy induction ( 20 , 21 ). Pectolinarigenin is a natural extract from multiple herbal medicinal plants, including Cirsium japonicum, Eupatorium odoratum and Trollius chinensis ( 22 ). Previous studies have reported that pectolinarigenin demonstrates potent inhibitory activity on melanogenesis and effective antitumor activity in vivo and in vitro ( 10 , 15 ).…”

Section: Discussionmentioning

confidence: 99%

Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells

Deng

Zhang

et al. 2020

Oncol Lett

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Pectolinarigenin a plant secondary metabolite that has various biological effects, including the inhibition of melanogenesis and tumor growth. Melanoma has a high degree of malignancy, with rapid metastasis and severe drug resistance, explaining the need for new candidate drugs that inhibit tumor growth and metastasis. However, the pharmacological action and mechanism of pectolinarigenin on the growth and metastasis of melanoma remain elusive. Thus, the present study aimed to investigate the role of pectolinarigenin in melanoma cell proliferation, apoptosis, migration and invasion. Apoptotic and metastasis-associated proteins were analyzed using western blotting. The results demonstrated that pectolinarigenin treatment resulted in growth inhibition and apoptosis induction in melanoma cells, arising from the loss of mitochondrial transmembrane potential, reactive oxygen species and the altered expression of apoptosis-associated proteins. In addition, wound-healing and Transwell assays demonstrated the potential of pectolinarigenin to impair the migration and invasion of melanoma cells in accordance with the changes in the expression of the associated proteins. Therefore, the results of the present study suggested that pectolinarigenin may serve a pivotal role in promoting melanoma cell apoptosis and reducing metastasis, and may thus be a promising potential candidate for an anti-melanoma treatment strategy.

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Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway

Cited by 15 publications

References 35 publications

Selective Cytotoxicity of Portuguese Propolis Ethyl Acetate Fraction towards Renal Cancer Cells

Selective Cytotoxicity of Portuguese Propolis Ethyl Acetate Fraction towards Renal Cancer Cells

miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN

Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells

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