Pectus excavatum: Benefit of randomization

Dalton, Brian G.A.; Gonzalez, Katherine W.; Millspaugh, Daniel L.; Desai, Arti D.; Sharp, Susan W.; Peter, Shawn D. St.

doi:10.1016/j.jpedsurg.2015.05.009

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…The use of TEA is heavily influenced by local experience, excessive failure rates , and rare complications. Three cases of spinal cord injury following TEA for PE have been reported of which anesthetic details are available only for one.…”

Section: Discussionmentioning

confidence: 99%

A review of anesthetic techniques and outcomes following minimally invasive repair of pectus excavatum (Nuss procedure)

Frawley

Crameri

2016

Pediatric Anesthesia

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Section: Discussionmentioning

confidence: 99%

A review of anesthetic techniques and outcomes following minimally invasive repair of pectus excavatum (Nuss procedure)

Frawley

Crameri

2016

Pediatric Anesthesia

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“…Two types of randomization can be considered: fixed randomization, which gives each included patient the same likelihood of receiving one of the treatments, regardless of the time of inclusion in the trial; and adaptive randomization, which gives each included patient the likelihood of receiving one of the treatments, depending on the time of inclusion [16]. The latter allows the correction of a possible imbalance in the number of patients or in the initial disease characteristics compared.…”

Section: Copyrightmentioning

confidence: 99%

Planning Clinical Trials: The Main Step in Developing New Drugs

Bourin¹

2017

SOJPPS

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A therapeutic trial is generally conducted to determine a new treatment or improve therapeutic applications. Several crucial questions should be considered before the trial is undertaken. The planning of a clinical trial involves a succession of steps intended to develop a protocol providing a clear and unbiased answer to a precise therapeutic question. What treatments are to be compared? What type of population should be studied? What are the evaluation criteria? What is the most suitable experimental scheme? How many patients should be included? What statistical procedures should be implemented (single analysis, intermediary analysis, serial analysis)? This paper considers briefly the main points to be resolved at each planning stage.

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“…S ir — Epidural analgesia has been an important part of the perioperative care of children undergoing thoracic surgery for over 60 years. One limitation is that the analgesic failure rate of thoracic epidurals, when implemented as an unsupplemented analgesic technique, has been reported to be as high as 30% . The placement of pediatric epidural catheters normally occurs following induction of general anesthesia, thus precluding patient feedback regarding proper placement in the epidural space.…”

Section: Predictors Of Epidural Analgesic Failurementioning

confidence: 99%