Pecularities of determining the content of 3-substituted 4-hydroxycoumarins in disinfectants and drugs

Кочетов, А. Н.; Shestakov, K. A.; Shpilevskii, G. M.; Kuz'mina, L. G.

doi:10.1007/s11094-013-0906-5

Pharm Chem J

2013

DOI: 10.1007/s11094-013-0906-5

|View full text |Cite

Pecularities of determining the content of 3-substituted 4-hydroxycoumarins in disinfectants and drugs

А. Н. Кочетов¹,

K. A. Shestakov²,

G. M. Shpilevskii³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2017

2018

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Establishment of Isomeric Composition of Insecticidal Cypermethrin Substance by Rp-HPLC

Nosikova

Кочетов²

2017

Fine Chem. Tech.

View full text Add to dashboard Cite

The determination of cypermethrin, one of the most sought pyrethroid insecticides having a wide range of activities, by isocratic RP-HPLC is considered. The analysis of substances (technical products) with different content of both the geometrical (cis-, trans-) and optical (zetacypermethrin and alfacypermethrin) isomers of cypermethrin was carried out. Information about the content of the most active forms of cis- allows evaluating the effectiveness of the biological substance based only on RP-HPLC data, which in turn can be a decisive factor in the of the substance assessment supplier / manufacturer or ready commercial products. The optimum concentration range for determining the geometric isomers of cypermethrin in the working solution is from 0.2 to 1.0 mg/ml. The substance detection limit in working solutions/washings is 0.005 mg/ml.

show abstract

Establishment of Isomeric Composition of Insecticidal Cypermethrin Substance by Rp-HPLC

Nosikova

Кочетов²

2017

Fine Chem. Tech.

View full text Add to dashboard Cite

show abstract

Analysis of Insecticide Gels Containing Fipronil by Rp HPLC

Nosikova

Кочетов

2018

Fine Chem. Tech.

View full text Add to dashboard Cite

The article considers fipronil determination by the method of RP HPLC in isocratic mode with ultraviolet detection at 280 nm. The analysis of insecticidal gels containing fipronil and fipronil mixture with chlorpyriphos was carried out. The possibility and expediency of determining the isomeric composition of fipronil were considered. The conditions for carrying out extraction of insecticides from gel matrices containing food attractive, including additional processing by ultrasound, were determined. The developed mode of extraction of active ingredients (fipronil and chlorpyriphos) is based on the preferred homogenization of the gel sample with a minimum amount of water followed by extraction with isopropanol acidified with acetic acid. The proposed scheme differs from the previously realized chloroform extraction by the stage of sample preparation. However, under these conditions in case of the gel matrix it is possible to achieve a high degree of homogeneity of the sample and to prevent possible hydrolysis of the target components. At the same time, the selected conditions are well combined with the polarity of the mobile phase upon direct separation. Selected chromatography modes allow identifying the title compound in real insecticides without overlapping signals from other extractable components using the trivial stationary phases. The possibility and expediency of carrying out chromatographic analysis to determine the optical isomers of the title compounds with different insecticidal activity have been considered. The optimal concentration range of fipronil determination in the working solution is from 0.005 to 0.15 mg/ml (chlorpyriphos, from 0.002 to 0.15 mg/ml). The limit of determination of substance in the working solution/swabs is 0.0005 mg/ml.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Pecularities of determining the content of 3-substituted 4-hydroxycoumarins in disinfectants and drugs

Cited by 2 publications

References 79 publications

Establishment of Isomeric Composition of Insecticidal Cypermethrin Substance by Rp-HPLC

Establishment of Isomeric Composition of Insecticidal Cypermethrin Substance by Rp-HPLC

Analysis of Insecticide Gels Containing Fipronil by Rp HPLC

Contact Info

Product

Resources

About