Peculiar IgA transfer in the pigeon from mother to squab

Goudswaard, J.; Donk, J.A. van der; Gaag, I van der; Noordzij, A.

doi:10.1016/s0145-305x(79)80027-0

Cited by 35 publications

(24 citation statements)

References 5 publications

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“…As demonstrated in this study a small portion of crop milk IgA is obviously resorbed by 1-day-old squabs. In contrast with Goudswaard et al (1979) this study failed to show further transfer of IgA in 2 and 3-day-old pigeons. However, most of the crop milk IgA as well as IgG will remain in the intestine to provide local immunity.…”

Section: Figure 2 Sds-page Of Pigeon Serum Globulins On a Linear Porcontrasting

confidence: 99%

“…No further high molecular weight globulins like IgM could be demonstrated in crop milk using SDS-PAGE. This finding is in accordance with results obtained from the study of Goudswaard et al (1979). The authors were not able to detect IgM in crop milk by agarose gel immunoelectrophoresis.…”

Section: Figure 2 Sds-page Of Pigeon Serum Globulins On a Linear Porsupporting

confidence: 92%

“…After removing the fat and treating with sodium sulphate, only one gel filtration is required to isolate highly purified IgA. The results of the molecular weight determination support the assumption of Goudswaard et al (1979) that crop milk IgA exclusively appears in the dimeric state and is probably not provided with a secretory component. If pigeon secretory IgA shows the same characteristics as chicken secretory IgA (Porter & Parry, 1976), a molecular weight higher than 360,000 would be expected.…”

Section: Figure 2 Sds-page Of Pigeon Serum Globulins On a Linear Porsupporting

confidence: 59%

“…Goudswaard et al (1979) propose that IgA present in crop milk is derived from the bloodstream and reaches the crop via the saliva. This hypothesis still remains to be verified.…”

Section: Figure 2 Sds-page Of Pigeon Serum Globulins On a Linear Pormentioning

confidence: 99%

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Quantification of the immunoglobulin classes IgG and IgA in the young and adult pigeon(Columba livia)

et al. 1992

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SUMMARYPigeon immunoglobulin classes IgG and IgA were purified and specific isotype antisera were produced in rabbits. The antisera were used to develop a quantitative assay for both immunoglobulins.Serum IgG concentrations in relation to age showed a similar pattern in pigeons to that in chickens. The same applies to the transfer of maternal immunoglobulins via egg. Besides this transfer mechanism, an additional transfer of immunoglobulins exists in the pigeon via feeding of crop milk. Crop milk contains considerable amounts of IgA (1.45 mg/ml) and significantly less IgG (0.34 mg/ml). During day 1 intestinal absorption of IgA is possible to a very low extent. Most of the IgA, as well as IgG, remains in the intestine to provide local immunity.

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Section: Figure 2 Sds-page Of Pigeon Serum Globulins On a Linear Porcontrasting

confidence: 99%

Section: Figure 2 Sds-page Of Pigeon Serum Globulins On a Linear Porsupporting

confidence: 92%

Section: Figure 2 Sds-page Of Pigeon Serum Globulins On a Linear Porsupporting

confidence: 59%

“…Goudswaard et al (1979) propose that IgA present in crop milk is derived from the bloodstream and reaches the crop via the saliva. This hypothesis still remains to be verified.…”

Section: Figure 2 Sds-page Of Pigeon Serum Globulins On a Linear Pormentioning

confidence: 99%

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Quantification of the immunoglobulin classes IgG and IgA in the young and adult pigeon(Columba livia)

et al. 1992

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“…IgA was subsequently identified in the blood, bile, and secretions of the turkey (Meleagris gallopavo) (Goudswaard et al, 1977a;Hädge and Ambrosius, 1988), pigeon (Columba livia) (Goudswaard et al, 1977b), duck (Anas platyrhynchos) (Ng and Higgins, 1986;Magor et al, 1998;Hädge and Ambrosius, 1988), and goose (Anser anser) (Hädge and Ambrosius, 1988). In a remarkable example of convergent evolution, pigeons transport IgA from the circulation into "crop milk," with which they feed their young (Goudswaard et al, 1979). Like amphibian IgX, IgA in birds lacks a hinge region and has four C H domains, rather than the three C H domains found in mammalian IgA (Warr et al, 1995).…”

Section: Birdsmentioning

confidence: 99%

Phylogeny and Comparative Physiology of Mucosal Immunoglobulins

Kaetzel

Russell

2015

Mucosal Immunology

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Secretory immune system of the duck (Anas platyrhynchos ). Identification and expression of the genes encoding IgA and IgM heavy chains

et al. 1998

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IgA has not previously been identified in waterfowl. Studies instead revealed physical and antigenic similarities between duck bile immunoglobulin (Ig) and serum IgM. Here, a differential screening approach was used to clone, from a duck spleen library, the cDNA encoding the heavy (H) chains of IgM and the Ig, identified here as IgA, occurring in duck secretions. Phylogenetic comparisons of inferred amino acid sequences of entire H chain constant (C) regions and of individual domains revealed that the duck mu chain was closest to chicken mu (54% overall identity), and duck alpha was closest to chicken alpha (50% identity). Comparison of the mu and alpha C regions revealed areas of up to 65% amino acid similarity within the C4 domains, accounting for the previously noted antigenic overlap of duck IgM and IgA. Messages for alpha and mu were detected in duck lymphoid organs but the alpha message was most abundant in the respiratory, alimentary and reproductive tracts. The alpha message first appeared around 14 days of age and reached adult levels of expression only at 35-50 days. The results indicate that the duck has a mucosal immune system which utilizes IgA; however, the delayed expression and secretion of duck IgA explains the susceptibility of ducklings to mucosal pathogens. Since the waterfowl are among the most primitive extant birds, the recognition of IgA in the duck supports the conclusion that IgA occurs throughout the class Aves and also existed in the common ancestors of birds and mammals.

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Peculiar IgA transfer in the pigeon from mother to squab

Cited by 35 publications

References 5 publications

Quantification of the immunoglobulin classes IgG and IgA in the young and adult pigeon(Columba livia)

Quantification of the immunoglobulin classes IgG and IgA in the young and adult pigeon(Columba livia)

Phylogeny and Comparative Physiology of Mucosal Immunoglobulins

Secretory immune system of the duck (Anas platyrhynchos ). Identification and expression of the genes encoding IgA and IgM heavy chains

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