Peculiar lifespan changes of periodic leg movements during sleep in restless legs syndrome

Ferri, Raffaele; DelRosso, Lourdes M.; Silvani, Alessandro; Cosentino, F.; Picchietti, Daniel L.; Mogavero, Maria Paola; Manconi, Mauro; Bruni, Oliviero

doi:10.1111/jsr.12896

Cited by 30 publications

(15 citation statements)

References 45 publications

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“…Another possibility that cannot be discounted at present is that rodent models of RLS are characterized by an increased occurrence of non‐periodic tibialis anterior EMG bursts during sleep. This would be in line with the data that PLMS make up less than 20% of total leg movements during sleep in children and adolescents with RLS, 20 and that adult patients with RLS have significantly greater frequency not only of PLMS, but also of non‐periodic leg movements during sleep, including SILMS, compared with healthy controls 21 …”

Section: Resultssupporting

confidence: 86%

“…Another possibility that cannot be discounted at present is that rodent models of RLS are characterized by an increased occurrence of non-periodic tibialis anterior EMG bursts during sleep. This would be in line with the data that PLMS make up less than 20% of total leg movements during sleep in children and adolescents with RLS, 20 and that adult patients with RLS have significantly greater frequency not only of PLMS, but also of non-periodic leg movements during sleep, including SILMS, compared with healthy controls. 21 Consequently, the task force recommended that the occurrence of tibialis anterior EMG bursts be reported as a function of the distribution of inter-burst interval and, ideally, also of the number of bursts per run, to allow clear comparison with data in other animal models and humans.…”

Section: Periodic Leg Movementssupporting

confidence: 89%

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Consensus Guidelines on Rodent Models of Restless Legs Syndrome

et al. 2020

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Restless legs syndrome (RLS) is a chronic sensorimotor disorder diagnosed by clinical symptoms. It is challenging to translate the diagnostic self‐reported features of RLS to animals. To help researchers design their experiments, a task force was convened to develop consensus guidelines for experimental readouts in RLS animal models. The RLS clinical diagnostic criteria were used as a starting point. After soliciting additional important clinical features of RLS, a consensus set of methods and outcome measures intent on capturing these features—in the absence of a face‐to‐face interview—was generated and subsequently prioritized by the task force. These were, in turn, translated into corresponding methods and outcome measures for research on laboratory rats and mice and used to generate the final recommendations. The task force recommended activity monitoring and polysomnography as principal tools in assessing RLS‐like behavior in rodents. Data derived from these methods were determined to be the preferred surrogate measures for the urge to move, the principal defining feature of RLS. The same tools may be used to objectively demonstrate sleep‐state features highly associated with RLS, such as sleep disturbance and number and periodicity of limb movements. Pharmacological challenges and dietary or other manipulations that affect iron availability are desirable to aggravate or improve RLS‐like behavior and lend greater confidence that the animal model being proffered replicates key clinical features of RLS. These guidelines provide the first consensus experimental framework for researchers to use when developing new rodent models of RLS. © 2020 International Parkinson and Movement Disorder Society

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Section: Resultssupporting

confidence: 86%

Section: Periodic Leg Movementssupporting

confidence: 89%

Consensus Guidelines on Rodent Models of Restless Legs Syndrome

et al. 2020

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“…Interestingly, all RLS cases were detectable among men with HIV duration of more than 20 years. Recently, age-related changes in the periodicity of PLMS have been reported in individuals with RLS, stabilizing during middle age but increasing after the age of 60 [31]. Whether such age-related phenomena also occur in older people with HIV is currently unknown but merits future study.…”

Section: Plos Onementioning

confidence: 95%

Prevalence and correlates of restless legs syndrome in men living with HIV

Wallace

Alcaide

Wohlgemuth³

et al. 2021

PLoS ONE

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Background Data on the prevalence and correlates of restless legs syndrome (RLS) in people with HIV are limited. This study sought to determine the prevalence of RLS, associated clinical correlates, and characterize sleep-related differences in men with and without HIV. Methods Sleep-related data were collected in men who have sex with men participating in the Multicenter AIDS Cohort Study (MACS). Demographic, health behaviors, HIV status, comorbidities, and serological data were obtained from the MACS visit coinciding with sleep assessments. Participants completed questionnaires, home polysomnography, and wrist actigraphy. RLS status was determined with the Cambridge-Hopkins RLS questionnaire. RLS prevalence was compared in men with and without HIV. Multinomial logistic regression was used to examine correlates of RLS among all participants and men with HIV alone. Sleep-related differences were examined in men with and without HIV by RLS status. Results The sample consisted of 942 men (56% HIV+; mean age 57 years; 69% white). The prevalence of definite RLS was comparable in men with and without HIV (9.1% vs 8.7%). In multinomial regression, HIV status was not associated with RLS prevalence. However, white race, anemia, depression, and antidepressant use were each independently associated with RLS. HIV disease duration was also associated with RLS. Men with HIV and RLS reported poorer sleep quality, greater sleepiness, and had worse objective sleep efficiency/fragmentation than men without HIV/RLS. Conclusions The prevalence of RLS in men with and without HIV was similar. Screening for RLS may be considered among people with HIV with insomnia and with long-standing disease.

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“…On the contrary, other medications, such as levetiracetam, perampanel, or gabapentin, can reduce the PLMI, 49,50 while valproic acid or carbamazepine do not seem to have any effect on PLMS. 51,52 Taking into account that PLMS are frequently associated with RLS in children 53 and that they are present since adolescence, 54,55 antidepressants or antipsychotics should be used with caution in pediatric psychiatric disorders, to avoid the possible drug-induced onset or worsening of PLMS. 43 There are currently no Food and Drug Administration (FDA)approved medications for RLS in children and therapeutic protocols for pediatric RLS are lacking.…”

Section: Rlsmentioning

confidence: 99%

Restless sleep disorder, restless legs syndrome, and periodic limb movement disorder—Sleep in motion!

DelRosso

Mogavero

Ferri

2021

Pediatric Pulmonology

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Sleep‐related movement disorders (SRMDs) represent an important part of pediatric sleep disorders. The most common complaint in SRMD is restless sleep at night. Restless sleep is reported in up to 80% of children with restless legs syndrome (RLS) and children with periodic limb movements of sleep (PLMS) disorder (PLMD). However, restless sleep causing daytime behavioral consequences can be seen in children without another apparent condition and has recently been identified as a new independent primary pediatric sleep disorder, called restless sleep disorder (RSD). This study describes these three main SRMDs (RSD, RLS, and PLMD), explains the new consensus criteria for RSD, emphasizes the rapidly evolving areas of research in this field, and proposes recommendations for future research. In particular, the published data constitute convincing evidence that sleep‐related movements are disruptors of sleep quality and continuity. However, while important advancements have recently been reported in adults, a detailed analysis of the phenomenology and consequences of sleep‐related movements has just started in children. New approaches, standardized diagnostic methods, and specific guidelines are needed in the field of pediatric SRMD.

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Peculiar lifespan changes of periodic leg movements during sleep in restless legs syndrome

Cited by 30 publications

References 45 publications

Consensus Guidelines on Rodent Models of Restless Legs Syndrome

Consensus Guidelines on Rodent Models of Restless Legs Syndrome

Prevalence and correlates of restless legs syndrome in men living with HIV

Restless sleep disorder, restless legs syndrome, and periodic limb movement disorder—Sleep in motion!

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