Peculiar modulation of taste aversion learning by the time of day in developing rats

Manrique, Tatiana; Gámiz, Fernando; Morón, Ignacio; Ballesteros, Ma Angeles; Gallo, M.

doi:10.1002/dev.20354

Cited by 12 publications

(14 citation statements)

References 82 publications

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“…In line with this notion and on the basis of their previous finding that environmental and temporal contexts can modulate taste aversion learning (Moron et al, 2002), Gallo and her colleagues (Manrique et al, 2009a,b) have studied modulation of taste aversion learning by the time of day (morning 9:00 or evening 19:00) in rats of different ages ranging from 32-day-old to 25-month-old and the role of hippocampus in such a modulation. Their results suggest that the ability to form segregated representations of a complex experience is impaired in aging and abolished by lesions of the dorsal hippocampus.…”

Section: Avoidancementioning

confidence: 54%

Brain Mechanisms of Flavor Learning

Yamamoto¹,

Ueji²

2011

Front. Syst. Neurosci.

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Once the flavor of the ingested food (conditioned stimulus, CS) is associated with a preferable (e.g., good taste or nutritive satisfaction) or aversive (e.g., malaise with displeasure) signal (unconditioned stimulus, US), animals react to its subsequent exposure by increasing or decreasing ingestion to the food. These two types of association learning (preference learning vs. aversion learning) are known as classical conditioned reactions which are basic learning and memory phenomena, leading selection of food and proper food intake. Since the perception of flavor is generated by interaction of taste and odor during food intake, taste and/or odor are mainly associated with bodily signals in the flavor learning. After briefly reviewing flavor learning in general, brain mechanisms of conditioned taste aversion is described in more detail. The CS–US association leading to long-term potentiation in the amygdala, especially in its basolateral nucleus, is the basis of establishment of conditioned taste aversion. The novelty of the CS detected by the cortical gustatory area may be supportive in CS–US association. After the association, CS input is conveyed through the amygdala to different brain regions including the hippocampus for contextual fear formation, to the supramammillary and thalamic paraventricular nuclei for stressful anxiety or memory dependent fearful or stressful emotion, to the reward system to induce aversive expression to the CS, or hedonic shift from positive to negative, and to the CS-responsive neurons in the gustatory system to enhance the responsiveness to facilitate to detect the harmful stimulus.

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Section: Avoidancementioning

confidence: 54%

Brain Mechanisms of Flavor Learning

Yamamoto¹,

Ueji²

2011

Front. Syst. Neurosci.

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“…A similar result was reported by the same authors when analyzing the role of context in the renewal effect after extinction of fear memories during this ontogenetic period (Yap & Richardson, 2007). Manrique and collaborators (2009) also reported that the temporal context-dependency of latent inhibition, a hippocampal-dependent phenomenon (Molero, Moron, Angeles Ballesteros, Manrique, Fenton & Gallo, 2005), emerges late in adolescence. What is happening in this developmental stage in response to experimental preparations assessing the role of context in these interference paradigms is reminiscent of similar phenomena in rats with hippocampal inactivation or lesions.…”

Section: Discussionmentioning

confidence: 97%

The unconditioned stimulus pre‐exposure effect in preweanling rats in taste aversion learning: Role of the training context and injection cues

Revillo

Arias

Spear

2012

Developmental Psychobiology

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The unconditioned stimulus pre‐exposure effect (US‐PE) refers to the interference paradigm in which acquisition of the conditioned response is retarded due to prior experience with the US. Most studies analyzing the psychological mechanisms underlying this effect have been conducted with adult rats. The most widely accepted hypothesis explains this effect as a contextual blocking effect. Contextual cues associated with the US block the conditioned stimulus (CS)‐US association during conditioning. The modulatory role of a context devoid of distinctive olfactory attributes is not observable until approximately PD23 in rats, including modulation of interference paradigms such as latent inhibition or extinction. In this study, we analyzed US‐PE in preweanling rats along with the role of the training context in this effect in terms of conditioned taste aversion preparation. Pre‐exposure to LiCl before conditioning retarded the acquisition of taste aversion. The US‐PE was observed in preweanling rats when, during pre‐exposure, subjects were exposed to the conditioning context, and this effect was not attenuated either by the administration of the US in a familiar environment (Experiment 1a), or by the presence of an alternative, more salient context during pre‐exposure (Experiment 1b). Additionally, the US‐PE was still observed when the route by which the US was administered was changed between the pre‐exposure and conditioning phases (Experiment 2a) as well as when the injection cues were removed during conditioning (Experiment 2b). These experiments show a strong US‐PE in preweanling rats and fail to support the contextual blocking hypothesis, at least in this stage of ontogeny. © 2012 Wiley Periodicals, Inc. Dev Psychobiol 55: 193–204, 2013

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“…The magnitude of a conditioned taste aversion (CTA) can be modulated by a change in the time of day between conditioning and test (Manrique, Gámiz, Morón, Ballesteros, & Gallo, 2009;Morón et al, 2002). This procedure shows that animals tested in temporal contexts different from that of the conditioning acquire less aversion, which is similar to what has been consistently described by changing the spatial context (Boakes, Elliot, Swinbourne, & Westbrook, 1997;Bonardi, Honey, & Hall, 1990;Bouton, 1993;Bouton, Westbrook, Corcoran, & Maren, 2006;González, Garcia-Burgos, & Hall, 2012;Pearce & Bouton, 2001;Rosas & Bouton 1997).…”

Section: Taste Stimulus Restriction Temporal Contextmentioning

confidence: 49%

Circadian-temporal context and latent inhibition of conditioned taste aversion: Effect of restriction in the intake of the conditioned taste stimulus

Molero‐Chamizo

2016

Learn Behav

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Latent inhibition of conditioned taste aversion (CTA) is sensitive to changes in the temporal context. A change in the time of day of conditioning with respect to the time of day of the preexposure can disrupt the latent inhibition. This contextual change in the time of day may reveal a temporal specificity of latent inhibition. The optimum procedure to induce this temporal specificity is not well established. For example, it has been shown that a long period of habituation to temporal contexts is one factor that can determine the effect. However, the experimental conditions on the conditioning day that facilitate this phenomenon are unknown. The aim of this study is to elucidate whether a restriction in the intake of the conditioned taste stimulus affects the temporal specificity of latent inhibition. Two main groups of Wistar rats were tested in a latent inhibition of CTA paradigm, in which the temporal specificity of this phenomenon was analyzed by a change in the time of day of conditioning. The intake of the taste stimulus was restricted in the conditioning day in one of the groups, but this restriction was not applied in the other group. The results indicated temporal specificity of latent inhibition only in the group without restriction, but not in the group with limitation in the intake of the taste stimulus during conditioning. These findings can help to elucidate the characteristics of the procedure to induce temporal specificity of latent inhibition.

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Peculiar modulation of taste aversion learning by the time of day in developing rats

Cited by 12 publications

References 82 publications

Brain Mechanisms of Flavor Learning

Brain Mechanisms of Flavor Learning

The unconditioned stimulus pre‐exposure effect in preweanling rats in taste aversion learning: Role of the training context and injection cues

Circadian-temporal context and latent inhibition of conditioned taste aversion: Effect of restriction in the intake of the conditioned taste stimulus

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