Peculiarities of clinical course of inflammatory diseases of the oropharynx of various etiologies and possibilities of local therapy

Кryukov, A. I.; Гуров, А. В.; Yushkina, M. A.; Изотова, Г. Н.

doi:10.17116/otorino20198405168

Cited by 4 publications

(2 citation statements)

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“…Для ХТ ТАФ I характерно наличие местных признаков ХТ, как при простой форме заболевания, а также наличие общих токсико-аллергических реакций -периодического повышения температуры тела до субфебрильных значений, повышенная утомляемость, слабость, разбитость, миалгии, артралгии, кардиалгии, функциональные нарушения сердечной деятельности. Сопутствующие заболевания, как и ХТ простой формы, не имеют общей этиопатогенетической основы с ХТ [22,23].…”

Section: Introductionunclassified

“…Также возможно появление местных и общих сопряженных заболеваний. Это заболевания, имеющие общую этиопатогенетическую основу с ХТ (паратонзиллярный абсцесс, парафарингит, ревматизм, приобретенные болезни сердца, тонзиллогенный сепсис) [22,23].…”

Section: Introductionunclassified

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Comparative characteristics of the options for conservative therapy of chronic tonsillitis of toxic-allergic form I

et al. 2021

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Introduction. The high incidence of chronic tonsillitis (CT), as well as the high risk of complications, make research in this area very relevant. The ambiguity of approaches to conservative therapy determines the need to search for new, reasonably effective, chemotherapy regimens.Objective. To carry out a comparative characteristic of various options for conservative therapy of chronic tonsillitis of toxicallergic form (TAF) I degree (CT TAF I).Materials and methods. The study included patients with CT TAF I according to the classification of B.S. Preobrazhensky and V.T. Palchun. The patients were divided into three clinical groups, depending on the therapy. Patients of the first group underwent a course of washing the lacunae of the tonsils with 1% dioxidine solution. Patients of the second group were prescribed antibiotic therapy with a retard form of clarithromycin. Patients of the third group underwent complex treatment – washing the lacunae of the palatine tonsils and simultaneously taking antibiotic therapy. The effectiveness of treatment was assessed by comparing the dynamics of changes in complaints, pharyngoscopic symptoms of CT, regional lymph nodes, and laboratory parameters.Results. Complex conservative therapy of CT TAF I provides early relief of patients’ complaints (in 93.2% of patients on the 7th day from the start of treatment), the maximum decrease in the severity of local CT symptoms (up to 1 point on the VAS at the end of treatment, with the exception of the Zak sign — 1.4 points) and the greatest positive dynamics of laboratory parameters.Conclusions. The analysis showed that for patients with CT TAF I, complex therapy, including a course of washing the lacunae of the palatine tonsils with 1% dioxidine solution and simultaneous administration of antibacterial therapy with a retard form of clarithromycin, is the most optimal therapeutic tactic that allows to achieve an earlier and stable reduction in the severity of symptoms HT, patient complaints, as well as the normalization of laboratory parameters.

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Comparative characteristics of the options for conservative therapy of chronic tonsillitis of toxic-allergic form I

et al. 2021

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Comparative characteristics of the effectiveness of local therapy in acute tonsillopharyngitis

Овчинников¹,

Мирошниченко²,

Akopyan³

et al. 2022

Vestn. otorinolaringol.

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Selection of effective therapy for inflammatory diseases of the pharynx

Ryazantsev,

Vysockaya,

Fanta

et al. 2023

Medicinskij sovet

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Inflammatory processes of the upper respiratory tract and pharynx occupy a leading position both in terms of the frequency of visits to an otolaryngologist and in the variety of pathogenic factors that cause processes accompanied by sore throat. With an inflammatory process occurring in the lymphoid ring of the pharynx, symptoms are usually caused by local factors, so local treatment, both anti-inflammatory and analgesic, is especially important. However, according to the literature, in most cases systemic antibacterial therapy is prescribed. According to modern concepts, it is known that systemic antimicrobial agents should be prescribed strictly according to indications, since the viral etiology of the inflammatory process is the most common. Based on this point of view, non-steroidal anti-inflammatory drugs are effective. In turn, according to many studies, preparations of the lysine salt of ketoprofen have shown their effectiveness in relieving symptoms without leading to the development of obvious side effects. Based on a review of literature data, it is shown that the lysine salt of ketoprofen has a wide therapeutic potential, good tolerability, and ease of use, which allows us to recommend this drug for use in patients with acute inflammatory processes in the pharynx caused by both microbial and viral agents. This drug is one of the most effective because there is no interaction with other drugs, and it can be used as part of combination therapy with antiseptics. If it is necessary to carry out antibacterial therapy for the treatment of an acute or exacerbation of a chronic process in the pharyngeal cavity, the drug of choice can be considered a third-generation semisynthetic cephalosporin antibiotic for oral administration with a broad spectrum of action, cefixime.

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Peculiarities of clinical course of inflammatory diseases of the oropharynx of various etiologies and possibilities of local therapy

Cited by 4 publications

References 4 publications

Comparative characteristics of the options for conservative therapy of chronic tonsillitis of toxic-allergic form I

Comparative characteristics of the options for conservative therapy of chronic tonsillitis of toxic-allergic form I

Comparative characteristics of the effectiveness of local therapy in acute tonsillopharyngitis

Selection of effective therapy for inflammatory diseases of the pharynx

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