Peculiarities of Determining the Gastric Acid Secretion and Diabetic Autonomic Neuropathy in Patients With Chronic Pancreatitis and Type 2 Diabetes

Sirchak, Yelyzaveta S; Barani, V. Ye.; Odoshevska, O. M.; Petrichko, O.I.

doi:10.36740/wlek202104132

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…The initial state of the central nervous system and any functional disturbances were determined by means of Wayne's questionnaire. [19][20][21][22] The questionnaire refers to 9 parameters, which are evaluated by a doctor during an objective functional examination of the patient. Each parameter is evaluated on a scale of 3-8 points.…”

Section: Determination Of the Cardiovascular System Function And The ...mentioning

confidence: 99%

Changes in the periodontium against the background of systemic vascular reactions in young individuals with obesity

Skrypnyk¹,

Petrushanko²,

Непорада³

et al. 2023

Dent. Med. Probl.

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Background. Overweight and obesity are defined as abnormal or excessive fat accumulation that impairs health. The global prevalence of obesity has been increasing significantly among all age groups. Further more, obesity is a comorbid factor for numerous diseases, including cardiovascular and periodontal pathologies.Objectives. The present study aimed to investigate the influence of overweight and obesity on the peri odontium of young adults in relation to the functional state of the cardiovascular system. Material and methods.The oral health status of 132 males and females aged 18-22 years was exa mined. They were divided into 4 groups according to their body mass index (BMI): normal weight; over weight; class I obesity; and class II obesity. A periodontal chart, the records on oral hygiene and caries, and periodontal indices were provided for each participant. The main functional parameters of the cardiovascu lar system were measured before and after the dental examination.Results. Overweight or obesity did not affect the intensity of caries in young adults. The prevalence and severity of gingivitis were significantly higher in obese individuals. A moderate correlation was found be tween gingivitis and BMI in patients with class I and II obesity. Disturbances in the cardiovascular system function and in the autonomic nervous system tone were also diagnosed in obese patients. An impaired vascular response and significant functional changes in the cardiovascular system developed against the background of obesity. These changes show the development of subcompensation in young adults with obesity.Conclusions. In obese individuals, significantly worse oral hygiene was observed as compared to normal BMI patients. Moreover, the clinical manifestation and intensity of gingivitis in obese individuals were high even in those with satisfactory oral hygiene. In young obese individuals, the periodontal disease mani fested as gingivitis is due to significant adaptive and compensatory mechanisms.

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Section: Determination Of the Cardiovascular System Function And The ...mentioning

confidence: 99%

Changes in the periodontium against the background of systemic vascular reactions in young individuals with obesity

Skrypnyk¹,

Petrushanko²,

Непорада³

et al. 2023

Dent. Med. Probl.

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“…Для виявлення ознак вегетативних порушень у пацієнтів гастроентерологічного профілю використовується опитувальник Вейна, який складається з 11 питань. Сума балів понад 15 свідчить про високу ймовірність наявності дисфункції АНС [9,10]. Як свідчить аналіз вітчизняної та зарубіжної літератури, у пацієнтів із ХП часто спостерігаються тривожнодепресивні розлади.…”

Section: 2022unclassified

Effect of autonomic dysfunction on the exocrine function of the pancreas in chronic pancreatitis

Sabat

Бабинец

2023

GASTRO

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Background. The article evaluates the impact of autonomic dysfunction according to the heart rate variability data and the Spielberger-Khanin questionnaire on the exocrine function of the pancreas in chronic pancreatitis (CP). The aim is to evaluate the exocrine function of the pancreas depending on the heart rate variability and survey using the Spielberger-Khanin questionnaire. Materials and methods. One hundred outpatients with a diagnosis of CP who were treated in Ternopil healthcare institutions were examined. The presence of exocrine pancreatic insufficiency was determined by the level of fecal α-elastase. The psycho-emotional state was assessed using the Spielberger-Khanin questionnaire. Statistical and spectral indicators of heart rate variability were analyzed: the range of variation, the amplitude of the mode, stress index, indicator of activity of regulatory systems, total spectrum power, absolute and percentage values of very low frequency (VLF), low frequency (LF), high frequency power (HF), the LF/HF ratio. A correlation analysis was performed of the obtained heart rate variability data, the Spielberger-Khanin questionnaire data with the degree of exocrine pancreatic insufficiency in terms of the level of fecal α-elastase. Results. The average value of reactive anxiety on the Spielberger-Khanin questionnaire is 44.33 ± 0.89, personal anxiety is 43.19 ± 0.82, which corresponds to the upper limit of the moderate level. A negative correlation was found between these parameters and the level of fecal α-elastase (r = –0.482, p < 0.01, and r = –0.555, p < 0.01, respectively). Based on the heart rate variability of patients with CP, a tendency among them to sympathicotonia was detected, which was accompanied by a significant increase in the amplitude of the mode, stress index, the LF/HF ratio and a decrease in the range of variation compared to the control group. In contrast to the healthy individuals, the humoral-metabolic effect of heart rhythm regulation prevailed in those with CP (VLF — (48.66 ± 1.21) %) and the share of the nervous component (LF — (31.69 ± 0.67) %, HF — (19.65 ± 0.75) %) decreased, there was a significant decrease in the total power of the spectrum compared to the control group (1546.25 ± 44.18 versus 3155.65 ± 211.38). The indicator of the activity of regulatory systems in patients with CP (6.91 ± 0.12) was at the upper limit of the intense load of regulatory systems, which reflects a significant impairment of adaptation among them and reliably differs from the control level (3.90 ± 0.31). A significant correlation was found between the total power of the spectrum, indicator of the activity of regulatory systems and the level of fecal α-elastase (r = 0.511, p < 0.01, and r = –0.398, p < 0.01, respectively). Conclusions. During the study, it was found that with a deterioration in the psycho-emotional state (according to the data of the Spielberger-Khanin questionnaire), exocrine insufficiency of the pancreas in patients with CP increased: there was a correlation between the content of fecal α-elastase and the level of reactive and personal anxiety. Positive statistically significant correlations between the amplitude of the mode, stress index with the duration of the course of CP indicate compensatory activation of the sympathetic division of the autonomic nervous system. It was also proved that exocrine insufficiency (according to the content of fecal α-elastase) worsened with an increase in sympathicotonia (according to the stress index). A decrease in the functional reserve in patients with СР was revealed: a significant decrease in the total power of the spectrum was found compared to that of the control group; against this background, there was a decrease in the adaptive potential, deterioration in the psycho-emotional state, which resulted in an increase in exocrine pancreatic insufficiency. The obtained data motivate to improve the generally accepted comprehensive therapy of patients with chronic pancreatitis with the additional inclusion in it of agents to stabilize the autonomic nervous system.

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The effect of body weight and psychological characteristics on periodontal disease development

Skrypnyk,

Petrushanko,

Neporada

et al. 2023

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Aim: The aim of the study was to examine the association between periodontal health in young patients with various body mass indexes and psychological traits such as temperament, level of anxiety, and autonomic nervous system tone. Materials and methods: The study included 132 male and female subjects aged 18–22 years with different body mass indexes (BMI). They were allocated into four groups by their BMIs: normal weight, overweight, and first- and second-degree obesity. We completed periodontal charts for all patients and evaluated basic oral hygiene and periodontal indexes, such as the Green-Vermillion index (OHI), the approximal plaque index by Lange (API), and papilla bleeding index by Saxer & Mühlemann (PBI). Eysenck personality questionnaire, the state-trait anxiety inventory of Spielberger-Khanin, and Wayne questionnaire were used to determine the psychological characteristics. Results: Patients with the first and second degrees of obesity were found to have the highest prevalence and severity of generalized gingivitis (up to 90%). Patients with normal BMI had significantly lower levels of extraversion and higher levels of neuroticism than the obese individuals, while subjects with extra weight and normal BMI were more emotionally stable. We found no evidence that choleric or melancholic temperament had an impact on BMI or periodontal health. However, phlegmatic temperament was found to be linked to a normal BMI, good oral hygiene, and an intact periodontium, while sanguine temperament was linked to obesity and gingivitis in young adults. A significantly higher level of state and trait anxiety was observed in obese individuals. Fifty percent of the obese subjects had disturbances of the functional state of the cardiovascular system and the tone of the autonomic nervous system. Conclusions: Because obesity and periodontal pathology are multifactorial diseases linked to lifestyle, stress tolerance, and habits, personality temperament may play a causal role in their development.

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Peculiarities of Determining the Gastric Acid Secretion and Diabetic Autonomic Neuropathy in Patients With Chronic Pancreatitis and Type 2 Diabetes

Cited by 3 publications

References 5 publications

Changes in the periodontium against the background of systemic vascular reactions in young individuals with obesity

Changes in the periodontium against the background of systemic vascular reactions in young individuals with obesity

Effect of autonomic dysfunction on the exocrine function of the pancreas in chronic pancreatitis

The effect of body weight and psychological characteristics on periodontal disease development

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