Peculiarities of Etiology of Respiratory Virus Infections in Hospitalized Patients Depending on the Demographic, Socio-Economic Factors and Previous Vaccination

Abstract

Etiology of respiratory virus infections among 1699 hospitalized patients (HP) was determined by PCR during the period of increased influenza activity in 2012 - 2013 season. The rate of accidence of influenza virus in dependence of gender, age, social and demographic factors and previous vaccination was analysed. Young children dominated in the age structure of HP, while the elderly were hospitalized very rarely. According to results obtained rate of influenza detection in HP was significantly higher among adults in comparison with children (63,5 and 30,7% of investigated patients, correspondingly). Respiratory syncytial virus and rhinoviruses were detected the most regularly (8.7 and 3.1%, correspondingly) in children, parainfluenza and adenoviruses were registered rarely (1.4 and 2.1%, correspondingly). Rate of detection of coronaviruses and bocavirus was low and varied in the range 0.3 - 0.6%. Indicated above ARI agents among hospitalized adults were detected rarely (0 - 1.5%) with exception of RSV which was detected among elderly (75 - 84 years) in 5.9% cases. No metapneumovirus cases were detected among HP in indicated period. Although males dominated (58%) among HP influenza cases, regardless of the type/subtype, were registered more frequently among girls in comparison with the boys of the same age groups. Influenza cases were registered more frequenly as well among smoking than in not smoking patients. Young children dominated in the age structure of HP, while the elderly were hospitalized very rarely.

Metapneumovirus infection in children in modern conditions: clinical and immunological parallels

“…Вместе с тем отсутствие полной регистрации и ограниченная доступность этиологической верификации в реальной практике не позволяют представить истинные масштабы заболеваемости и «клиническое лицо» этой собирательной группы инфекционных болезней. Данные отечественной и зарубежной литературы свидетельствуют об изменении этиологического спектра ОРВИ в последние годы, указывая на рост удельного веса риновирусной, метапневмовирусной, коронавирусной инфекции в популяции [1,2,3,4,5,6]. Обращает на себя внимание также увеличение роли вирусных агентов в качестве триггеров в развитии иммунопатологических синдромов (васкулитов, вторичного гемофагоцитарного синдрома и т.д.).…”

Influenza Vaccine Effectiveness Assessed at Different Stages of the Epidemic Cycle in Reducing the Frequency of Hospitalization with Influenza

“…Ковариаты. Демографическая, клиническая и эпидемиологическая информация была получена от всех включенных в исследование пациентов, как описано ранее [4]. Собранные базовые данные вводили в индивидуальную карту больного (ИКБ).…”

Respiratory Syncytial Virus G Protein Sequence Variability among Isolates from St. Petersburg, Russia, during the 2013–2014 Epidemic Season

“…In children, RSV is implicated in: 50–90% of bronchiolitis; 5–40% of pneumonia; and 10–30% of tracheobronchitis [ 3 , 4 , 5 ]. During the 2012–2013 epidemic season in St. Petersburg, the frequency of RSV infection was 13.5% (comparable to that of influenza) among hospitalized children in the first year of life [ 6 ].…”