Peculiarities of myocardial electrogenesis in laboratory rats under conditions of acute nitrite intoxication

Shumilova, T. E.; Shereshkov, V. I.; Yanvareva, I. N.; Nozdrachev, A. D.

doi:10.1134/s0022093010020079

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…Although mean values of the duration of the PR (PQ ) interval were comparable among the different types of anesthesia and did not exhibit significant differences (Table 2, Figure 2), the shortest duration was found with nembutal anesthesia [114]. With this type of anesthesia, there is a problem with the validity of this value because it is from only one study.…”

Section: Prognostic Significance Of Changes In the Atrial Complex In ...mentioning

confidence: 89%

“…The mentioned examples confirm the informative value of changes in the duration of the QT interval in the evaluation of the severity of disorders in the dispersion of ventricular refractory periods and their impact on the onset and development of ventricular arrhythmias. If we consider the values from telemetry studies, in terms of reference value and range [21,26,117,118], QT interval prolongation was measured with virtually every type of barbiturate anesthesia; as such, under pentobarbital [32, 34, 37, 38, 40, 41, 43-45, 47-50, 122, 124-126], thiopental [61-64, 66, 67, 69], and Nembutal anesthesia [114]. Ketamine/xylazine [45, 78, 85, 87, 89-92, 129, 136], ketamine/medetomidine [96], ketamine/diazepam [96,98], and ketamine/ midazolam [97], anesthesia had the greatest effect on QT interval prolongation.…”

Section: Qt Intervalmentioning

confidence: 99%

“…When comparing the average value of QRS complex duration from telemetry studies [21,31,[117][118][119] to barbiturate anesthesia-under pentobarbital [32, 34, 37, 40, 42, 44-49, 51, 122, 124-126, 154], thiopental [31,61,63,64,68,69,71], and Nembutal [114] anesthesia-the average value of the QRS complex duration was somewhat shorter and the ranges did not differ significantly.…”

Section: Qrs Complexmentioning

confidence: 99%

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Rat Electrocardiography and General Anesthesia

Švorc¹

2023

Novel Pathogenesis and Treatments for Cardiovascular Disease

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General anesthesia is an established and well-known factor with a significant impact on cardiac parameters, which can be a problem in the final evaluation of changes in the individual electrophysiological myocardial parameters after various interventions. The present chapter provides a composite review of published data on electrocardiographic parameters (heart rate, PR interval, P wave duration, P wave amplitude, QRS complex, QT and QTc interval duration, and R wave and T wave amplitude) for in vivo rat experiments under general anesthesia from 130 articles, which were retrieved from a search of the Web of Science database, for articles published mainly between 2000 and 2021. ECG parameters reported as baseline or control values were summarized, and averages with ranges were calculated. It is important to be cautious in interpreting the results of such studies and discussions addressing the mechanisms underlying a given type of arrhythmia, it is important to acknowledge that initial ECG parameters may already be affected to some extent by general anesthesia as well as by sex and the time of day the experiments are performed. Although it is not an original research work, researchers working with rats in the laboratory, who routinely perform anesthesia, can use this as a reference to look into while analyzing their data.

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Section: Prognostic Significance Of Changes In the Atrial Complex In ...mentioning

confidence: 89%

Section: Qt Intervalmentioning

confidence: 99%

Section: Qrs Complexmentioning

confidence: 99%

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Rat Electrocardiography and General Anesthesia

Švorc¹

2023

Novel Pathogenesis and Treatments for Cardiovascular Disease

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“…5(165.6-171.5), n = 3) [7,30,31]; pent -Pentobarbital (161. 1(156.1-165.7), n = 6) [32][33][34][35][36][37]; , n = 5) [38][39][40][41][42]; , n = 1) [43]; , n = 4) [44][45][46][47]; Uret -Urethane (187. 5(183.7-191.2), n = 2) [48,49]; zoletil -Zoletil anesthesia (145.05(136.…”

Section: Distribution Of Average Values and Ranges Of Rr Intervals From Telemetry Studies And Under Different Types Of General Anesthesiamentioning

confidence: 99%

The Autonomic Nervous System, Sex Differences, and Chronobiology under General Anesthesia in In Vivo Experiments Involving Rats

Švorc¹

2022

Autonomic Nervous System - Special Interest Topics

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The aim was to evaluate the current state of the autonomic nervous system (ANS) activity under general anesthesia using heart rate variability (HRV) in dependence on the light-dark (LD) cycle in healthy, sexually mature, spontaneously breathing, zoletil-anesthetized (30 mg/kg) Wistar rats of both sexes after a 4-week adaptation to an LD cycle (12 h:12 h). The animals were divided into four experimental groups according to sex and light period (n = 20 each). RR interval duration, spectral power at very-low-frequency (VLF), low-frequency (LF) and high-frequency (HF), total spectral power of HRV, and the LF/HF ratio were analyzed. Sympathetic and baroreceptor activity was decreased, and parasympathetic activity was increased in both sexes and in both light periods. Regarding sex differences, HRV was significantly lower in females versus males in the light period. In the dark period, females exhibited higher HRV than males. Regarding LD differences, in females, HRV was lower in the light versus the dark period, unlike males, in which HRV was higher in the dark versus the light period of the rat regimen day. Sex differences in the activity of the ANS were apparent in rats, persisted under general anesthesia, and were dependent on the LD cycle.

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Effect of Direct and Mediated through Maternal Organism Activation of the Catecholaminergic System on Heart Rate Parameters in Rat Fetuses

Vdovichenko,

Nikonorova

2024

Bull Exp Biol Med

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Peculiarities of myocardial electrogenesis in laboratory rats under conditions of acute nitrite intoxication

Cited by 3 publications

References 15 publications

Rat Electrocardiography and General Anesthesia

Rat Electrocardiography and General Anesthesia

The Autonomic Nervous System, Sex Differences, and Chronobiology under General Anesthesia in In Vivo Experiments Involving Rats

Effect of Direct and Mediated through Maternal Organism Activation of the Catecholaminergic System on Heart Rate Parameters in Rat Fetuses

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