Peculiarities of Planning an Experiment to Study the Wound Process

Abstract

Experimental models play an important role in studying skin wound healing, developing new treatment modes, and analyzing the effectiveness of existing methods. However, there are some issues and limitations that should be considered when conducting and interpreting medical trials. One of the main difficulties is the diversity of the existing models. Some may not fully reflect human life processes, which makes it difficult to transfer research results into clinical practice. Vague standardization and a large number of experimental options complicate the research. Some methods are not enough sensitive or specific, which may lead to erroneous results. This article is a review of some most common animal wound models. The authors consider the basic principles of experimental design, including the choice of appropriate animal models, and methods for evaluating skin wounds in laboratory animals. Despite limitations, rational experimental animal studies remain one of the most useful tools for answering a variety of questions on the fundamentals of wound healing. The study and adaptation of animal wound models may contribute to the development of effective wound treatment modes.