2013
DOI: 10.24061/1727-4338.xii.1.43.2013.51
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Peculiarities of the Etiology and Pathogenesis of Intrahepatic Cholestasis Inpregnancy

Abstract: ïèòàííÿ åò³îëî㳿, ïàòîãåíåçó, ôàêòîðè ðèçèêó, ùî ïðèçâîäÿòü äî ðîçâèòêó âíóòð³øíüîïå÷³íêîâîãî õîëåñòàçó âàã³òíèõ. Îñíîâíèìè ïðè÷èíàìè ðîçâèòêó âíóòð³øíüîïå÷³íêîâîãî õîëåñòàçó âàã³òíèõ ââàaeàþòüñÿ ãåíåòè÷íà ñõèëüí³ñòü òà âïëèâ åñòðîãåí³â ï³ä ÷àñ âàã³òíîñò³. Çâåðíåíà óâàãà íà ðîëü ó ïàòîãåíåç³ âíóòð³øíüîïå÷³íêîâîãî õîëåñòàçó âàã³òíèõ äèñôóíêö³¿ òðàíñïîðòíèõ ñèñòåì áàçîëàòåðàëüíî¿ ³ êàíàë³êóëÿðíî¿ ìåìáðàí ãåïàòîöèòà, ùî çóìîâëþþòü ïîðóøåííÿ ñåêðåö³¿ aeîâ÷³.

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