Peculiarities of the Pregnancy in Women with Hepatobiliary System Pathology

Abstract

During pregnancy, there is a significant restructuring of various organs and systems, including liver functions. Due to the increase in circulating blood volume, most indicators of liver function may differ from their level in non-pregnant women. In the liver of pregnant women, the synthesis of a large class of proteins (excluding immunoglobulins), fibrinogen, prothrombin, blood coagulation factors (V, VII, X, XI, XII, XIII), fibrinolytic factors (antithrombin III, proteins C and S) increases. Hepatic enzymes (serum transaminases, γ-glutamyltranspeptidase), as well as the bilirubin content do not change during the physiological course of pregnancy 1 .