Peculiarities of vanadium determination in whole blood by icp-ms

Ts, Ulanova; Ov, Gileva; Ev, Stenno; Ga, Veĭkhman

doi:10.18097/pbmc20146001109

BIOMED KHIM

2014

DOI: 10.18097/pbmc20146001109

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Peculiarities of vanadium determination in whole blood by icp-ms

Ulanova Ts

Gileva Ov

Stenno Ev

et al.

Abstract: The parameters of vanadium determination by ICP-MS in whole blood are presented. Conditions for blood sample preparation to reduce measure errors and to determine vanadium at the reference concentration level were optimized. The accuracy of the results is confirmed by analysis of standard blood samples Seronorm L1, L2 and L3. Vanadium mean in whole blood for the group of children from the town of Chusovoy (n=80) was 1.29±0.45 µg/L, and vanadium mean for grown – ups from the town of Chusovoy was 1.63±0.25 µg/L.

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“…In the elemental analysis laboratory of Federal Scientific Center for Medical and Preventive Health Risk Management Technologies (Perm) there were developed and introduced the techniques of simultaneous determination of 12 chemical elements (vanadium, chrome, manganese, nickel, cuprum, zinc, selenium, strontium, thallium, lead, cadmium, arsenic) in biomedia [3][4][5][6] [7] and used in routine clinical diagnosis of health situation in population living in territories with negative impact of the environment, as well as for control after rehabilitation treatment in hospital environment.…”

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Determination of Toxic and Essential Elements in Urine by Inductively Coupled Plasma-Mass Spectrometry

Veikhman¹,

Gilyova²,

Stenno³

et al. 2016

Sovrem Tehnol Med

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The aim of the investigation was to optimize the conditions of a routine urinalysis by inductively coupled plasma mass spectrometry (ICP-MS) for diagnostic studies.Materials and Methods. We determined the content of 12 elements (V, Cr, Mn, Ni, Cu, Zn, As, Se, Sr, Cd, Tl, Pb) in the urine of children in Russian industrial region (n=57, mean age being under 6 years) by ICP-MS on a quadrupole mass spectrometer Agilent 7500cx (Agilent Technologies, USA) with octopole collision/reaction cell according to the methodology developed by MUK 4.1.3230-14. Conclusion.The proposed easy method to determine the essential and toxic elements in urine using a mass spectrometer Agilent 7500cx with octopole collision/reaction cell can be recommended for diagnostic and screening tests in clinical settings.

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mentioning

confidence: 99%

“…The complex standard solution 209 Bi, 73 Ge, 115 In, 6 Li, 45 Sc, 159 Tb, 89 Yс with concentration of 10 mg/L in 5% water solution of HNO 3 (Internal Standard Mix; Aligent Technologies, USA) was used to prepare the internal standard (IS) solutions.…”

mentioning

confidence: 99%

Determination of Toxic and Essential Elements in Urine by Inductively Coupled Plasma-Mass Spectrometry

Veikhman¹,

Gilyova²,

Stenno³

et al. 2016

Sovrem Tehnol Med

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Determination of strontium content in whole blood and urine by ICP-MS

et al. 2015

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Parameters of strontium determination in the whole blood and urine of children living near ore deposits containing up to 20% strontium sulfate have been determined. The average strontium content in the whole blood of two children groups of 109.52±11.07 mg/L and 131.62±12.95 mg/L, significantly exceeded the level in the comparison group 44.2±4.24 mg/L. The average strontium contents of two groups of children in urine were 1252.3±332.2 mg/L and 1341.5±241.8 mg/L, these values were 4.2 and 4.5 times higher than in the comparison group 296.4±61.5 mg/L. The conditions for blood and urine sample preparation were optimized to reduce measure errors and to determine strontium at the reference concentration level. The accuracy of the results has been confirmed by analysis of the standard samples SeronormTM Whole Blood L1, L2, L3 and SeronormTM Urine.

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Features of the Elemental Composition of Whole Blood in Children’s Population of the Western Ural

Zaitseva

Ulanova

Veikhman

et al. 2019

HAS

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Introduction. The element composition of blood is the most relevant index in biomonitoring studies to assess public health risks. The authors determined the elemental composition of the whole blood in 100 the unexposed children residing in the West Ural region using the ICP-MS method and standard biomonitoring methodology of the World Health Organization (WHO). This study allows for improving the comparability and reliability of the analysis results, as well as to supplement information on human biomonitoring for various territories of the Russian Federation. A comparative assessment of the contents of vanadium, chromium, manganese, nickel, copper, zinc, arsenic, selenium, strontium, cadmium, thallium and lead with reference concentrations used in national programs for human biomonitoring (BMC) of European countries and the United States was made. Material and methods. The authors determined mass concentrations of V, Cr, Mn, Ni, Cu, Zn, As, Se, Sr, Cd, Tl, and Pb by ICP-MS in conformity with Methodical Guidelines 4.1. 3230-14 (FR.1.31.2014.17064) developed by the authors. The article contains setting parameters for quadrupole mass spectrometer with inductively coupled plasma (Agilent 7500cx), the optimal sample preparation scheme for eliminating the “matrix” effect. The operating mode of the mass spectrometer with a response/collision cell to mitigate interferences and the choice of internal standards is justified. The sample preparation of whole blood was made by acid dissolution followed by centrifugation. The detection limits (LOD) for each element are calculated. Results. The results are presented in the form of basic statistics: minimum and maximum values, arithmetic mean (AM), geometric mean (GM), 5, 50, 95 percentiles and interpreted in accordance with modern international requirements. The geometric mean (GM) of element content in blood amounted to 0.11 µg/l (V); 5.34 µg/l (Cr); 13.1 µg/l (Mn); 3.15 µg/l (Ni); 854.7 µg/l (Сu); 4655.0 µg/l (Zn); 0.13 µg/l (As); 84.97 µg/l (Se); 28.0 µg/l (Sr); 0.28 µg/l (Сd); 0.05 µg/l (Tl); 18.63 µg/l (Pb). The validity of the results was confirmed by means of SERONORM TM Whole Blood L2 standard samples (Norway). The results of the study relied upon the 95 percentile (P95) can be used as approximate reference data as a basis for assessing the risk associated with exposure to metals. Conclusion. Regional differences from levels found in other Europe countries (Italy, Norway) and the USA included higher concentrations of Mn, Cr and Ni and lower levels of Cu, Zn and Se in blood of children in the rural areas of the West Ural region. The optimal method for determining the content of essential and toxic elements in blood by mass spectrometry with inductively coupled plasma has been substantiated and recommended for practical use (MG 4.1. 3230-14, FR.1.31.2014.17064).

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Peculiarities of vanadium determination in whole blood by icp-ms

Cited by 3 publications

References 3 publications

Determination of Toxic and Essential Elements in Urine by Inductively Coupled Plasma-Mass Spectrometry

Determination of Toxic and Essential Elements in Urine by Inductively Coupled Plasma-Mass Spectrometry

Determination of strontium content in whole blood and urine by ICP-MS

Features of the Elemental Composition of Whole Blood in Children’s Population of the Western Ural

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