Peculiarity of Epilepsy in Elderly People: A Review

Sanya, E O

doi:10.4314/wajm.v29i6.68260

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Several studies have demonstrated increased incidence and prevalence of epilepsy in older age groups [107–109]. Epilepsy is the third most common type of brain disease in old age, after stroke and dementias [110, 111].…”

Section: Epilepsymentioning

confidence: 99%

Oxidative Stress and Epilepsy: Literature Review

Aguiar

Almeida

Araújo

et al. 2012

Oxidative Medicine and Cellular Longevity

242

171

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Backgrounds. The production of free radicals has a role in the regulation of biological function, cellular damage, and the pathogenesis of central nervous system conditions. Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis. Experimental studies suggest that oxidative stress is a contributing factor to the onset and evolution of epilepsy. Objective. A review was conducted to investigate the link between oxidative stress and seizures, and oxidative stress and age as risk factors for epilepsy. The role of oxidative stress in seizure induction and propagation is also discussed. Results/Conclusions. Oxidative stress and mitochondrial dysfunction are involved in neuronal death and seizures. There is evidence that suggests that antioxidant therapy may reduce lesions induced by oxidative free radicals in some animal seizure models. Studies have demonstrated that mitochondrial dysfunction is associated with chronic oxidative stress and may have an essential role in the epileptogenesis process; however, few studies have shown an established link between oxidative stress, seizures, and age.

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Section: Epilepsymentioning

confidence: 99%

Oxidative Stress and Epilepsy: Literature Review

Aguiar

Almeida

Araújo

et al. 2012

Oxidative Medicine and Cellular Longevity

242

171

View full text Add to dashboard Cite

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“…Late‐onset epilepsy, conventionally defined as the new occurrence of epilepsy in patients older than 60 years, has different clinical characteristics, including etiology, presence of epileptic auras, seizure manifestations, and features of the postictal period, than epilepsy in younger age groups (Sanya, 2010 ; Tanaka et al., 2013 ). Stroke and neurodegenerative disorders, including AD, are the main causes of late‐onset epilepsy (Sanya, 2010 ; Tanaka et al., 2013 ). Evidence suggests bidirectional associations between epilepsy and AD.…”

Section: Introductionmentioning

confidence: 99%

Brain networks and epilepsy development in patients with Alzheimer disease

Lee

Kim

et al. 2023

Brain and Behavior

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IntroductionThis study aimed to investigate the association between brain networks and epilepsy development in patients with Alzheimer disease (AD).MethodsWe enrolled patients newly diagnosed with AD at our hospital who underwent three‐dimensional T1‐weighted magnetic resonance imaging at the time of AD diagnosis and included healthy controls. We obtained the cortical, subcortical, and thalamic nuclei structural volumes using FreeSurfer and applied graph theory to obtain the global brain network and intrinsic thalamic network based on the structural volumes using BRAPH.ResultsWe enrolled 25 and 56 patients with AD with and without epilepsy development, respectively. We also included 45 healthy controls. The global brain network differed between the patients with AD and healthy controls. The local efficiency (2.026 vs. 3.185, p = .048) and mean clustering coefficient (0.449 vs. 1.321, p = .024) were lower, whereas the characteristic path length (0.449 vs. 1.321, p = .048) was higher in patients with AD than in healthy controls. Both global and intrinsic thalamic networks were significantly different between AD patients with and without epilepsy development. In the global brain network, local efficiency (1.340 vs. 2.401, p = .045), mean clustering coefficient (0.314 vs. 0.491, p = .045), average degree (27.442 vs. 41.173, p = .045), and assortative coefficient (−0.041 vs. −0.011, p = .045) were lower, whereas the characteristic path length (2.930 vs. 2.118, p = .045) was higher in patients with AD with epilepsy development than in those without. In the intrinsic thalamic network, the mean clustering coefficient (0.646 vs. 0.460, p = .048) was higher, whereas the characteristic path length (1.645 vs. 2.232, p = .048) was lower in patients with AD with epilepsy development than in those without.ConclusionWe found that the global brain network differs between patients with AD and healthy controls. In addition, we demonstrated significant associations between brain networks (both global brain and intrinsic thalamic networks) and epilepsy development in patients with AD.

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“…Volpato et al (2011) realizaram uma pesquisa envolvendo atividade física e qualidade de vida e mostraram uma tendência de menor medo de crises nos pacientes considerados ativos. Os autores sugerem que o grupo ativo apresenta uma maior 61 independência e enfrenta melhor sua condição, o que faz com que com eles realizem atividades cotidianas como trabalho, serviços domésticos e atividades de lazer.Apesar de com o passar dos anos a tendência de apresentar maiores problemas fisiológicos ser maior(PUGH et al, 2005;SANIA, 2010), os idosos parecem ser mais resistentes para enfrentar esta doença crônica.Com relação ao estigma, identificamos que os pacientes considerados ativos (42,60) possuem média de percepção de estigma menor, o que indica percepção estigma mais positiva, em comparação ao grupo não ativo(46,75).Os resultados apresentados nessa pesquisa sobre a relação do estigma com a qualidade de vida corroboram com o estudo deMorrel (2002), que identificou uma relação negativa, mostrando que quanto maior o estigma, menor a qualidade de vida. Tal negatividade também é apresentada no estudode Souza et al (2002), que indica que a baixa autoestima e qualidade de vida em adultos com epilepsia, são reflexos da percepção de estigma, dificuldades no trabalho e relacionamentos Jacoby (2002).…”

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Relações entre atividade física e aspectos psicológicos em pacientes com epilepsia

Kishimoto¹,

Fernándes²

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RESUMOA epilepsia é uma condição neurológica grave caracterizada por crises recorrentes e espontâneas no cérebro. Apesar de comum, pode prejudicar as funções cognitivas, emocionais e comportamentais, a capacidade de trabalho, o funcionamento social, a estabilidade familiar e a autoestima do paciente; influenciando assim sua qualidade de vida.Nos dias atuais, a saúde tornou-se um dos mais importantes benefícios associados à atividade física. Assim, o profissional de educação física tem adquirido um novo perfil no processo saúde, doença e cuidado. Neste sentido, este estudo teve como objetivo avaliar aspectos psicológicos (qualidade de vida, autoestima, resiliência, sintomas depressivos e estigma) em pacientes com epilepsia de lobo temporal, comparando com a intensidade de atividade física praticada pelos mesmos. Foram avaliados 80 pacientes com epilepsia de lobo temporal, associada à esclerose mesial hipocampal do Ambulatório de Epilepsia HC/UNICAMP (média±desvio padrão: 42 ±10,0 anos), sendo 31 homens, divididos em Grupo Ativo (61) e Grupo Não Ativo (19). Os instrumentos utilizados foram: 1) IPAQ: grau de atividade física 2) WHOQOL-bref: qualidade de vida 3) QOLIE-31: qualidade de vida específica na epilepsia 4) Escala de autoestima de Rosenberg: nível de autoestima 5) Escala de Resiliência: nível de resiliência 6) Inventário de Depressão de Beck: sintomas depressivos 7) Escala de Estigma na Epilepsia: percepção de estigma. Os resultados mostraram que os aspectos psicológicos foram avaliados em: qualidade de vida:

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Peculiarity of Epilepsy in Elderly People: A Review

Cited by 4 publications

References 43 publications

Oxidative Stress and Epilepsy: Literature Review

Oxidative Stress and Epilepsy: Literature Review

Brain networks and epilepsy development in patients with Alzheimer disease

Relações entre atividade física e aspectos psicológicos em pacientes com epilepsia

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