With the increased need for technology implementation, educational systems across the world have made various efforts to utilize technology to optimize learning efficacy. With regard to the MENA region, many reforms have been administered in order to effectively digitize education. Pedagogical aspects remain in great need of further investigation. Thus, through a conceptual review of applied pedagogical strategies, this chapter aims to explore issues related to such implementation in the MENA region. As pedagogy varies according to age, teaching environment, and subject, the author aims to explore the theory and practice of Mathematics teaching in online environments. The educational policy also diverges from one country to another, especially in terms of STEM education. The present study is based on a focus on the MENA region context which allows for a better understanding and development of STEM education. Moreover, this review provides issues and challenges to consider for future research and proposes pedagogical modifications to suit the online teaching environments.