In the context of the information era, the integration of industry and education, as a key direction for future educational reform, imposes higher standards on the quality of talent cultivation in colleges and universities. The study develops and investigates the hotel talent cultivation model and operation mechanism based on industry-education integration, starting from industry-education integration’s guiding ideology and principles. Then, in order to confirm the realistic feasibility of the hotel talent training model, the research object is selected, the relevant questionnaire is designed, and after the reliability test of the questionnaire, the questionnaire is distributed. The data are collected, and then the statistical analysis algorithm, including the difference test, correlation analysis, and regression analysis, is used to verify the examples. The data showed that corporate internship time, corporate internship environment, corporate internship management, corporate internship course planning, on-campus supervisors, and off-campus supervision were all significantly and positively correlated with satisfaction (Sig<0.05). At the same time, the regression equation was satisfaction= 0.2989+0.0459*corporate internship time+0.1329*corporate internship environment+0.0641*corporate internship management+ 0.1034*Enterprise Internship Curriculum Planning + 0.1017*Internship Supervisor + 0.0762* Externship Supervision. This study not only ensures the effectiveness, continuity, and standardization of talent cultivation but also helps to promote innovation in hotel talent cultivation modes in the context of industry-education integration.