Pedestal subwavelength grating metamaterial waveguide ring resonator for ultra-sensitive label-free biosensing

Chang, Chen-Wei; Xu, Xiaochuan; Chakravarty, Swapnajit; Huang, Hui‐Chun; Tu, Li‐Wei; Chen, Quark Yungsung; Dalir, Hamed; Krainak, Michael A.; Chen, Ray T.

doi:10.1016/j.bios.2019.111396

Cited by 46 publications

(29 citation statements)

References 48 publications

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“…The maximum attainable S mode for the optimized dimensions is 114%, which occurs when both upper and lower claddings contribute to perturb n eff (suspended structure). Recent work on SWG waveguides has shown a similar sensitivity enhancement by pedestaling the nanostructures by an additional wet-etch processing step [23]. Fig.…”

Section: Mode Sensitivity Analysismentioning

confidence: 85%

Mode Sensitivity Analysis of Subwavelength Grating Slot Waveguides

et al. 2019

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In this paper, we investigate the mode sensitivity (S mode) of subwavelength grating slot (SWGS) waveguides. S mode is an important parameter in various waveguide-based photonic circuits such as sensors, modulators, and thermally-controlled devices. It is a measure of the sensitivity of the waveguide effective index towards the refractive index perturbations in the cladding medium. The SWGS waveguide exhibits high mode sensitivity, as it combines sensitivity enhancement features of both slot and subwavelength grating waveguides. Finite-difference time-domain simulations are performed for the analysis, design, and optimization of the hybrid structure. The SWGS waveguide is incorporated into a Mach-Zehnder interferometer and fabricated on a silicon-on-insulator platform for the experimental estimation of S mode. The measured S mode value of 79% is consistent with the theoretical prediction of 83%.

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Section: Mode Sensitivity Analysismentioning

confidence: 85%

Mode Sensitivity Analysis of Subwavelength Grating Slot Waveguides

et al. 2019

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“…Licensed under a Creative Commons Attribution (CC BY) license. (b) Pedestal SWGMR-based biosensor for improved S. 74 Reprinted with permission from Chang et al , Biosens. Bioelectron.…”

Section: Integrated Optical Biosensorsmentioning

confidence: 99%

Section: Integrated Optical Biosensorsmentioning

confidence: 99%

“…In addition to utilizing the unique stable sensing characteristics of SWGMR and the enhanced Q of T-SWGMR, Chang et al 74 showed a pedestal T-SWGMR biosensor that maximizes the mode volume overlap by implementing an asymmetric refractive index distribution along the vertical direction on the silicon-on-insulator (SOI) platform, thereby further improving sensitivity [ Fig. 6(d) ].…”

Section: Integrated Optical Biosensorsmentioning

confidence: 99%

“…UT/OO has detected 67 fg/ml (1 fM), which is the lowest detected concentration reported. 97 UT/OO is in reference to published works jointly by UT, Austin, and Omega Optics, Inc. ASC Prague, Academy of Sciences of the Czech Republic; BIND, biomolecular interaction detection; KTH, KTH Royal Institute of Technology; LCR, liquid crystal sensors; 96 OFRR, opto-fluidic ring resonator; 94,95 PC, photonic crystal; 52,64,65,73–75,79–89 RR, ring resonator; 74,90–92 SPR, surface plasmon resonance; 45,93 U., University; U. Mich, University of Michigan; WG, waveguide.…”

Section: Integrated Optical Biosensorsmentioning

confidence: 99%

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Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challenges

Asghari

Wang

Yoo

et al. 2021

Applied Physics Reviews

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The sudden rise of the worldwide severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in early 2020 has called into drastic action measures to perform instant detection and reduce the rate of spread. Common clinical and nonclinical diagnostic testing methods have been partially effective in satisfying the increasing demand for fast detection point-of-care (POC) methods to slow down further spread. However, accurate point-of-risk diagnosis of this emerging viral infection is paramount as the need for simultaneous standard operating procedures and symptom management of SARS-CoV-2 will be the norm for years to come. A sensitive, cost-effective biosensor with mass production capability is crucial until a universal vaccination becomes available. Optical biosensors can provide a noninvasive, extremely sensitive rapid detection platform with sensitivity down to ∼67 fg/ml (1 fM) concentration in a few minutes. These biosensors can be manufactured on a mass scale (millions) to detect the COVID-19 viral load in nasal, saliva, urine, and serological samples, even if the infected person is asymptotic. Methods investigated here are the most advanced available platforms for biosensing optical devices that have resulted from the integration of state-of-the-art designs and materials. These approaches include, but are not limited to, integrated optical devices, plasmonic resonance, and emerging nanomaterial biosensors. The lab-on-chip platforms examined here are suitable not only for SARS-CoV-2 spike protein detection but also for other contagious virions such as influenza and Middle East respiratory syndrome (MERS).

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Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Wang

Sánchez

Yin

et al. 2020

Adv Materials Technologies

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By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation lab‐on‐a‐chip bioanalytical systems with a great potential for point‐of‐care medical diagnostics. Herein, an overview of the latest advances in silicon‐based integrated optofluidic label‐free biosensing technologies relying on the efficient interactions between the evanescent light field at the functionalized surface and specifically bound analytes is presented. State‐of‐the‐art technologies demonstrating label‐free evanescent wave‐based biomarker detection mainly encompass three device configurations, including on‐chip waveguide‐based interferometers, microring resonators, and photonic‐crystal‐based cavities. Moreover, up‐to‐date strategies for elevating the sensitivities and also simplifying the sensing processes are discussed. Emerging laboratory prototypes with advanced integration and packaging schemes incorporating automatic microfluidic components or on‐chip optoelectronic devices lead to one significant step forward in real applications of decentralized diagnostics. Besides, particular attention is paid to currently commercialized label‐free optical bioanalytical models on the market. Finally, the prospects are elaborated with several research routes toward chip‐scale, low‐cost, highly sensitive, multi‐functional, and user‐friendly bioanalytical systems benefiting to global healthcare.

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Pedestal subwavelength grating metamaterial waveguide ring resonator for ultra-sensitive label-free biosensing

Cited by 46 publications

References 48 publications

Mode Sensitivity Analysis of Subwavelength Grating Slot Waveguides

Mode Sensitivity Analysis of Subwavelength Grating Slot Waveguides

Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challenges

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

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