Pediatric Acute Hypoxemic Respiratory Failure: Management of Oxygenation

Prodhan, Parthak; Noviski, Natan

doi:10.1177/0885066604263859

Cited by 22 publications

(11 citation statements)

References 184 publications

(230 reference statements)

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“…Treatment with SNAP significantly reduced protein concentration in BALF and W/D ratio, suggesting that SNAP protects the integrity of the alveolar-capillary membrane. These effects can be attributed to involvement of NO in protection from oxidative injury, in regulation of both immune and inflammatory responses, in modulation of neutrophil sequestration into the lung, and in modulation of edema formation (Prodhan and Noviski 2004).…”

Section: Discussionmentioning

confidence: 99%

Effects of Nitric Oxide Donor on the Lung Functions in a Saline Lavage-Induced Model of ARDS

et al. 2019

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Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia, neutrophil-mediated inflammation, and lung edema formation. Whereas lung damage might be alleviated by nitric oxide (NO), goal of this study was to evaluate if intratracheal NO donor S-nitroso-N-acetylpenicillamine (SNAP) can positively influence the lung functions in experimental model of ARDS. New Zealand rabbits with respiratory failure induced by saline lavage (30 ml/kg, 9±3 times) were divided into: ARDS group without therapy, ARDS group treated with SNAP (7 mg/kg i.t.), and healthy Control group. During 5 h of ventilation, respiratory parameters (blood gases, ventilatory pressures) were estimated. After anesthetics overdosing, left lung was salinelavaged and cell count, cell viability and protein content in bronchoalveolar lavage fluid (BALF) were measured. Right lung tissue was used for estimation of wet/dry weight ratio, concentration of NO metabolites, and histomorphological investigation. Repetitive lung lavage induced lung injury, worsened gas exchange, and damaged alveolar-capillary membrane. Administration of SNAP reduced cell count in BALF, lung edema formation, NO metabolites, and histopathological signs of injury, and improved respiratory parameters. Treatment with intratracheal SNAP alleviated lung injury and edema and improved lung functions in a saline-lavaged model of ARDS suggesting a potential of NO donors also for patients with ARDS.

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Section: Discussionmentioning

confidence: 99%

Effects of Nitric Oxide Donor on the Lung Functions in a Saline Lavage-Induced Model of ARDS

et al. 2019

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“…Acute Respiratory Distress Syndrome (ARDS) was first described in 1967 in 12 adult patients. It was then addressed as Acute Hypoxaemic Respiratory Failure [1]. The American-European Consensus Conference on ARDS (1994) introduced the first definition of ARDS and another benign form of acute respiratory failure termed Acute Lung Injury (ALI).…”

Section: Discussionmentioning

confidence: 99%

“…The risk is higher in ARDS because normal and diseased lung tissues are interspersed. In addition, inappropriate ventilation may initiate an inflammatory cascade causing further damage to the surfactant system and worsening of pulmonary oedema [1]. The results from the ARDS network study in 2000 have changed the ventilator management of ARDS and ALI.…”

Section: Discussionmentioning

confidence: 99%

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Management of Acute Respiratory Distress Syndrome: A Challenge to Modern Medicine

Wmn¹

2014

Emergency Medicine

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Acute Respiratory Distress Syndrome (ARDS) is an acute inflammatory pulmonary injury in which marked oedema of the lungs causing progressive impairment of gas exchange, atelectasis, and decreased lung compliance. Over the years, several innovative methods to control the lung injury had been studied. Improvement in ventilation strategy has resulted in reduce mortality is ARDS patients. Meanwhile, adjunctive therapies such as inhaled nitric oxide, exogenous surfactant administration, patient positioning and immune-nutrition are other methods which may further improve the outcome of this condition. This case illustrates the use of multiple modalities of treatment which were useful in infant with this condition and a review of these treatment modalities.

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“…There is no evidence that hypocarbia during ventilation for sepsis is beneficial (and real evidence that over-ventilation may reduce preload to the right heart with subsequent decrease in cardiac output and can also lead to cerebral vasoconstriction and secondary ischemic brain injury), and some evidence that hypercarbia is not harmful and may well be beneficial [88]. In all cases ventilation should be provided using lung-protective strategies incorporating a tidal volume of approximately 6 mL/kg and a peak pressure of \30 cm H 2 O [89]. Strategies such as high-frequency oscillatory ventilation and prone ventilation may be useful adjuncts in patients with acute respiratory distress syndrome.…”

Section: Respiratory Supportmentioning

confidence: 99%

What’s New in the Recognition and Management of Septic Shock in Children: Dos and Don'ts

Argent

2013

Curr Pediatr Rep

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While there has been a reduction in the number of children dying of septic shock in the richer countries of the world, septic shock remains an important cause of both mortality and morbidity for children across the world. Major reduction in the incidence of septic shock will depend on the implementation of public health measures, including immunization. Improvements in outcome of pediatric septic shock have been closely linked to early recognition (although this may be challenging in many situations); early antibiotic administration; early and appropriate fluid administration and subsequent escalation of critical care. A particular challenge has been the development and implementation of systems to ensure that these elements of management are reliably and efficiently implemented in children (even in well-resourced countries). Recent studies have highlighted the complexity of caring for patients with acute severe sepsis and septic shock in countries with fewer resources, and there is an urgent need for further studies to elucidate the implications of these studies for the management of children with septic shock, particularly in settings where additional critical care support such as inotropic or ventilator support may not be readily available.

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Pediatric Acute Hypoxemic Respiratory Failure: Management of Oxygenation

Cited by 22 publications

References 184 publications

Effects of Nitric Oxide Donor on the Lung Functions in a Saline Lavage-Induced Model of ARDS

Effects of Nitric Oxide Donor on the Lung Functions in a Saline Lavage-Induced Model of ARDS

Management of Acute Respiratory Distress Syndrome: A Challenge to Modern Medicine

What’s New in the Recognition and Management of Septic Shock in Children: Dos and Don'ts

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