Pediatric Allergy

Rajaee, Arezoo; Masquelin, Meghane E.; Pohlgeers, Katherine M.

doi:10.1016/j.pop.2021.04.006

Cited by 4 publications

(2 citation statements)

References 59 publications

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“…The prevalence rate in the general population is 10-25%, and it is increasing each year. [1][2][3][4][5] The prevalence of self-reported AR is approximately 15% in Southeast China. 6 Members of the order Blattodea (eg, cockroaches), and marine crabs and lobsters produce the most important allergens in Quanzhou, which is a city in Southern Fujian Province, China.…”

Section: Introductionmentioning

confidence: 99%

Distributional Characteristics Analysis of Allergens in Patients with Allergic Rhinitis in Southern Fujian Province, China

He,

Gao,

Zhao

et al. 2024

JAA

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Background Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa. However, few studies focus on the distributional characteristics of allergens in AR patients in Southern Fujian Province, China. Methods A skin prick test (SPT) was performed and eight common allergens including Dermatophagoides farinae ( Df), Dermatophagoides pteronyssinus ( Dpt ), weeds, animal dander, molds, cockroaches, and mangoes were chosen. Results The positive reactions rate to the allergens was 65.79% in 6689 patients in Southern Fujian Province. Positive reactions to Df and Dpt had a negative association with age, whereas positive reactions to cockroach and weed had a positive association with age. A linear trend analysis demonstrated a significant positive relationship between positive reactions to various allergens from 2016 to 2019. Positive reactions to Df and Dpt were both correlated with the season. Positive reactions to Df, Dpt , cockroach and weed were related to disease duration and positive reactions to cockroach were correlated with city residence. Multivariate analysis revealed that male positive reactions gradually decreased with age (≤ 60), in contrast to female (≤ 60) positive reactions. Statistical difference was observed between the genders with regard to AR incidence from 2016 to 2019. The positive rate of skin tests was highest in summer in men, whereas in women it was lowest in summer. The gender composition ratios of positive cases in Xiamen, Zhangzhou, and Quanzhou cities differed significantly. The proportion of patients with positive reactions to the allergens in the three cities decreased with age. The highest proportions of patients with positive reactions all occurred during summer in the three cities. Furthermore, there were statistically significant differences in the age composition ratios across the seasons. Conclusion This study analyzed the distributional characteristics of AR allergens in Southern Fujian Province, China. These findings will inform specific immunotherapy for AR patients.

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Section: Introductionmentioning

confidence: 99%

Distributional Characteristics Analysis of Allergens in Patients with Allergic Rhinitis in Southern Fujian Province, China

He,

Gao,

Zhao

et al. 2024

JAA

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“…Manifestations include sneezing, itching in the nasal area, obstruction of airflow, and transparent nasal secretions, triggered by IgE-mediated responses ( 15 ). This condition has become a significant health issue globally ( 16 ), with an estimated 20% of the UK’s population affected ( 17 ). In China, a meta-analysis revealed that around 19% of adults and 22% of children are afflicted by AR ( 18 ), adversely influencing sleep quality, academic achievements, and life quality ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Causal association between air pollution and allergic rhinitis, asthma: a Mendelian randomization study

Zhong,

Li,

Yang

et al. 2024

Front. Public Health

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BackgroundsObservational studies suggest that air pollutants, including particulate matter and nitrogen compounds, could elevate asthma and allergic rhinitis health risks. Nevertheless, the exact nature of the causal relationship between air pollution and asthma and allergic rhinitis remains unknown. This study utilizes the Mendelian randomization (MR) technique to explore the potential causal links between air pollution components (PM2.5, PM2.5–10, PM10, NO₂, and nitrogen dioxide) and the incidence of allergic rhinitis and asthma.MethodsA MR study utilized summary statistics from GWAS that are publicly accessible. The inverse variance weighting (IVW) approach served as the foundational analysis technique. To ensure robustness, supplementary methodologies such as the weighted median, MR-Egger regression, simple mode, and weighted model were also applied. Heterogeneity was evaluated using Cochran’s Q test, and the presence of pleiotropy was determined through MR-Egger regression. The MR-PRESSO test was employed for outlier detection, and the analysis’s sensitivity was scrutinized via a leave-one-out strategy.ResultsThe IVW technique showed a strong correlation between PM10 and asthma (OR = 0.625, 95% CI = 0.396–0.988, p = 0.044). No significant associations were found between asthma and other air pollutants such as PM2.5, PM2.5–10, NO₂, or nitrogen dioxide. Similarly, allergic rhinitis showed no causal relationships with any studied air pollution metrics. Pleiotropy was absent in the findings. Sensitivity analyses, employing the leave-one-out method, confirmed the stability of these results, unaffected by individual single nucleotide polymorphisms (SNPs).ConclusionThis Mendelian randomization study establishes a causal link between PM10 exposure and asthma, suggesting that interventions to reduce air pollution may decelerate the adverse progression of asthma.

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Role of the dietary components in food allergy: A comprehensive review

Yang

Gao

et al. 2022

Food Chemistry

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Pediatric Allergy

Cited by 4 publications

References 59 publications

Distributional Characteristics Analysis of Allergens in Patients with Allergic Rhinitis in Southern Fujian Province, China

Distributional Characteristics Analysis of Allergens in Patients with Allergic Rhinitis in Southern Fujian Province, China

Causal association between air pollution and allergic rhinitis, asthma: a Mendelian randomization study

Role of the dietary components in food allergy: A comprehensive review

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