Pediatric alopecia areata following <scp>COVID</scp>‐19 infection

Herzum, Astrid; Viglizzo, Gianmaria; Gariazzo, Lodovica; Garibeh, Ehab; Occella, C.

doi:10.1111/jocd.15618

Cited by 3 publications

(2 citation statements)

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“…The affected genes are related to immune and inflammatory response genes, such as MHC, CTLA 4, and PRDX 5 ( 18 ). In addition, there is a high correlation between AA and other immune-mediated diseases (such as thyroiditis, diabetes, and vitiligo), which further supports the theory of immune pathogenesis in AA ( 42 ).…”

Section: Discussionsupporting

confidence: 65%

“…Scientists speculate that the autoimmune attack on hair follicles may also be related to viral infections. Viral infections (such as COVID-19) may induce oxidative stress, leading to upregulation of major histocompatibility complex class I (MHC-I) ligands on hair follicles, further activating T cells, destroying hair follicle cells, and releasing IFN-γ and TNF-α around hair follicles, thereby causing a vicious cycle of inflammation ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

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The correlation between corona virus disease 2019 and alopecia areata: a literature review

Xie,

Lv,

Luo

et al. 2024

Front. Immunol.

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Corona virus disease 2019(COVID-19) is one of the most serious respiratory pandemic diseases threatening human health for centuries. Alopecia areata (AA) is a sudden patchy hair loss, an autoimmune disease, which seriously affects the image and mental health of patients. Evidence shows that the risk of autoimmune diseases significantly increases after COVID-19, and is positively correlated with the severity, with a significant increase in the risk of alopecia in those over 40 years old. The relationship between COVID-19 and AA has become a hot topic of current research. Strengthening the research on the correlation between COVID-19 and AA can help to identify and protect susceptible populations at an early stage. This article reviews the research progress on the epidemiological background of COVID-19 and AA, the situation and possible mechanisms of AA induced by COVID-19 or COVID-19 vaccination, and potential treatment methods.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%