Pediatric Antiphospholipid Syndrome

Aguiar, Cassyanne L.; Soybilgic, Arzu; Avčin, Tadej; Myones, Barry L.

doi:10.1007/s11926-015-0504-5

Cited by 43 publications

(32 citation statements)

References 122 publications

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“…Furthermore, more recently, only few studies reported evidence of the beneficial use of IVIG to treat pediatric aPL-related chorea [9,10,[12][13][14][15]. Our clinical case confirmed the importance of the early use of IVIG treatment in CIDP children with aPL positivity.…”

Section: Resultssupporting

confidence: 80%

Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies

et al. 2020

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We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions. Video S1: Functional motor outcome before and after IVIG treatment. Author Contributions: Conceptualization, C.B., M.L., D.M.R., R.M.; methodology, C.B., M.L., G.N., R.S., G.F., E.M.; software, C.B., G.N., D.M.R.; validation, C.B., M.L., D.M.R., B.B., R.M., E.M.; formal analysis, C.B., M.L., D.M.R., R.S., G.F., M.P.; investigation, C.B., M.L., R.M., D.M.R.; resources, C.B., M.L., E.M., M.P.; data curation, C.B., M.L., D.M.R., R.S., G.F.; writing-original draft preparation, C.B., M.L., R.M.; writing-review and editing, C.B., M.L., D.M.R., B.B., R.M., M.P.; visualization, C.B., M.L., D.M.R., B.B., R.M., E.M., M.P.; supervision, C.B., M.L., D.M.R., B.B., R.M., M.P.; project administration, C.B., M.P.; funding acquisition, C.B., M.P. All authors have read and agreed to the published version of the manuscript. Funding: This research received no external funding. Conflicts of Interest:The authors declare no conflict of interest.

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Section: Resultssupporting

confidence: 80%

Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies

et al. 2020

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“…The role of immunotherapy has not been established and is usually reserved for patients with concurrent autoimmune diseases such as SLE. 135…”

Section: Antiphospholipid Antibody Syndromementioning

confidence: 99%

Autoimmune Neurologic Diseases in Children

Sweeney

2018

Semin Neurol

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Autoimmune diseases of the nervous system in children are composed of a heterogeneous group of rare disorders that can affect the central or peripheral nervous system at any level. Presentations may occur in children of any age and are typically acute or subacute in onset. Consideration of an autoimmune process as the etiology of neurologic diseases in children is important, as it may lead to early initiation of immunotherapy and an improvement in long-term neurologic outcomes. The developing nervous and immune systems in children create unique challenges in diagnosis and treatment of these rare diseases. In this review, autoimmune diseases affecting the brain, spinal cord, nerve roots, peripheral nerves, neuromuscular junction, and muscle in children are described.

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“…Alternatively, APS can be secondary to an autoimmune disorder-most commonly SLE-which is the attributed cause of $80% of pediatric cases of secondary APS. 4,41 Children with APS typically demonstrate arterial and deep vein thromboses and pulmonary emboli. 4 Thrombocytopenia, hemolytic anemia, and Evans syndrome (an autoimmune condition characterized by destruction of red blood cells, white blood cells, and platelets) represent hematologic manifestations; skin (Raynaud's phenomenon and livedo reticularis), kidney, heart, and neurologic involvement can also occur.…”

Section: Treatment and Prognosismentioning

confidence: 99%

“…4 Thrombocytopenia, hemolytic anemia, and Evans syndrome (an autoimmune condition characterized by destruction of red blood cells, white blood cells, and platelets) represent hematologic manifestations; skin (Raynaud's phenomenon and livedo reticularis), kidney, heart, and neurologic involvement can also occur. 41…”

Section: Treatment and Prognosismentioning

confidence: 99%

Central Nervous System Involvement in Pediatric Systemic Autoimmune Diseases

Stanton

Knight

2017

J Pediatr Neurol

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Central nervous system (CNS) involvement occurs in many pediatric systemic autoimmune diseases. These manifestations are often associated with increased morbidity and mortality and can have adverse long-term effects on neurodevelopmental, health-related, and quality-of-life outcomes. In this review, we summarize the existing literature on CNS involvement in pediatric systemic autoimmune diseases, compare diagnostic findings, and describe current treatments. CNS manifestations of pediatric systemic autoimmune disease present diagnostic and management challenges due to their relatively rare occurrence in children, the difficulty in confirming direct CNS involvement as opposed to secondary symptoms occurring as a consequence of systemic inflammation, and the need to define treatment strategies effective for CNS involvement.

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Pediatric Antiphospholipid Syndrome

Cited by 43 publications

References 122 publications

Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies

Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies

Autoimmune Neurologic Diseases in Children

Central Nervous System Involvement in Pediatric Systemic Autoimmune Diseases

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