Pediatric Baseline Patch Test Series: Pediatric Contact Dermatitis Workgroup

Yu, JiaDe; Atwater, Amber Reck; Brod, Bruce A.; Chen, Jennifer K.; Chisolm, Sarah; Cohen, David E.; Feld, Salma de la; Gaspari, Anthony A.; Martin, Katherine; Montanez‐Wiscovich, Marjorie; Sheehan, Michael P.; Silverberg, Nanette B.; Lugo-Somolinos, Aída; Thakur, Basant Kumar; Watsky, Kalman L.; Jacob, Sharon E.

doi:10.1097/der.0000000000000385

Cited by 44 publications

(18 citation statements)

References 37 publications

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“…A meta‐analysis done found that studies published after 1995 have reported higher rates of positive patch tests 8,9 . In recent years, unique patch test series have been developed to facilitate diagnosis and management of ACD in children 8,10 . Our rates of sensitization and relevant positive patch tests are similar to other studies published in the past decade 8,11,12 …”

Section: Discussionsupporting

confidence: 61%

Pediatric patch testing in a multi‐ethnic Asian population: A retrospective review

Lee

Wee

Tan

et al. 2021

Pediatric Dermatology

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Background Pediatric allergic contact dermatitis (ACD) is increasingly prevalent. Patch testing is the gold‐standard diagnostic investigation. The aims of our study were to describe the clinical profile of pediatric patients with ACD in a multi‐ethnic Asian population and identify the common contact allergens. Methods This was a retrospective study involving children and adolescents aged 16 years or younger with clinically suspected ACD who underwent patch testing between January 2007 and March 2020 at two institutions in Singapore. Information pertaining to their demographics, atopy history, clinical presentation, and patch test results was analyzed. Results A total of 252 patients were included. The mean age was 10.9 years (1.0–16.7 years). The majority were Chinese (79.8%) and girls (57.5%). Many (66.3%) had atopic dermatitis (AD), which was mild. The most common presentation was an acral eczematous rash. The sensitization rate was 50.0%. The most frequent reactions were to nickel sulfate (49.2%) and fragrance mix (19.1%). The overall rate of relevant positive patch tests was 72.5%. Patients with AD were less likely to have a reaction to fragrance mix (p = .019) and more likely to have a reaction to disperse blue (p = .041). Compared to younger children, adolescents were less likely to have a positive patch test (p = .008). Indians were also less likely to have a positive reaction (p = .004). Conclusion Metals and fragrances were the most common allergens causing childhood ACD in Singapore. Patients with AD were less likely to be sensitized to fragrances and more likely to be sensitized to disperse blue dye.

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Section: Discussionsupporting

confidence: 61%

Pediatric patch testing in a multi‐ethnic Asian population: A retrospective review

Lee

Wee

Tan

et al. 2021

Pediatric Dermatology

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“…In addition, two of the most common allergens encountered in children with HE in this study (benzalkonium chloride, oleamidopropyl dimethylamine) and one of the allergens that was significantly increased in children with HE (2-mercaptobenzothiazole) are not present on the American Contact Dermatitis Society recommended paediatric screening series. 25 Most of the HE-associated allergens are commonly used in personal care products and topical medications. Methylisothiazolinone is an almost ubiquitous preservative used in leave-on and rinse-off personal care products, including shampoos, conditioners, moisturizers and nail polish, industrial chemicals, paint, slime, adhesive agents and even prescription medications.…”

Section: Discussionmentioning

confidence: 99%

Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000–2016*

et al. 2021

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Learning & Change and has consulted for Henkel. J.S.T. owns noncontrolling shares of stock in AstraZeneca, Cigna, Merck, Johnson & Johnson and Opko Health. He has consulted for Kao Brands and Monsanto (Bayer), is a member of the Cosmetic Ingredient Review Steering Committee, and has a nondependent child employed by Pfizer. E.M.W. has received an investigator-initiated grant from and served as a consultant for Wen by Chaz Dean. She has also served as a consultant for Noven Pharmaceuticals. D.S. receives royalties SummaryBackground Little is known about the aetiologies and relevant allergens in paediatric patients with hand eczema (HE). Objectives To characterize the aetiologies and determine the proportion of positive and currently relevant allergens in children/adolescents (age < 18 years) with HE referred for patch testing. Methods A retrospective analysis (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016) of North American Contact Dermatitis Group data was performed. Results Of 1634 paediatric patients, 237 (14Á5%) had involvement of the hands. Final physician diagnoses included allergic contact dermatitis (49Á4%), atopic dermatitis (37Á1%) and irritant contact dermatitis (16Á9%). In multivariable logistic regression models, employment was the only association with increased odds of any HE or primary HE. Children with HE vs. those without HE had similar proportions of positive patch tests (56Á1% vs. 61Á7%; v 2 -test, P = 0Á11). The five most common currently relevant allergens were nickel, methylisothiazolinone, propylene glycol, decyl glucoside and lanolin. In multivariable logistic regression models of the top 20 relevant allergens, HE was associated with significantly higher odds of currently relevant reactions to lanolin, quaternium-15, Compositae mix, thiuram mix, 2-mercaptobenzathiazole and colophony. The allergens with the highest mean significance-prevalence index number were methylisothiazolinone, carba mix, thiuram mix, nickel and methylchloroisothiazolinone/methylisothiazolinone.

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“…An American survey of dermatologists and allergists conducting patch testing in children attending the 2017 American Contact Dermatitis Society meeting held in Washington, D.C., resulted in a discussion of collected data and a consensus review by a pediatric contact dermatitis working group at the conference. A baseline pediatric patch test panel for children above 6 years old was established through working group consensus children [150] and consists of 38 allergens: beside the allergens mentioned above, the following allergens were included: MI; formaldehyde releasers, i.e., quaternium-15, diazolidinyl urea, imidazolidinyl urea, DMDM hydantoin, bromonitropropanediol (bronopol), and iodopropynyl butylcarbamate; corticosteroids, i.e., tixocortol-21-pivalate, hydrocortisone-17butyrate, clobetasol-17-propionate, and budesonide; surfactants, i.e., cocamidopropyl betaine and its impurities dimethylaminopropylamine and amidoamine and emulsifiers, i.e., amerchol L101 and decyl glucoside; natural products, i.e., propolis, sesquiterpene lactone and Compositae mix, tea tree oil, cinnamic aldehyde, and carmine; bacitracin; propylene glycol; fragrance mix II; carba mix; and benzophenone-3.…”

Section: Is It Advisable To Test With a Shortened Standard Series Formentioning

confidence: 99%

Contact Allergy in Children

Goossens

Morren

2020

Contact Dermatitis

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Contact allergy in children is more frequent than previously suspected. Metals, ingredients of pharmaceutical and cosmetic products, preservatives/biocides, para-phenylenediamine, rubber additives, plastics and resins, and plants are known sensitizers in them. In adolescents, occupation-induced allergens may be involved as well. Sometimes unusual clinical presentations of allergic contact dermatitis can be observed. If there is a suspicion by history and clinical picture, or there is an unexplained eczema at particular body sites, patch testing should be performed at all ages. Patch testing in children is safe, but false-positive (as false-negative) reactions are, of course, possible. Patch test reactions must be interpreted carefully, particularly in atopic subjects, since their skin is readily irritated; this is especially the case for metals. An abbreviated baseline series, supplemented with relevant allergens from other test series, as well as contacted products and respective ingredients suggested by the history, should be patch tested.

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Pediatric Baseline Patch Test Series: Pediatric Contact Dermatitis Workgroup

Abstract: A baseline pediatric patch test panel was established through working group consensus.

Cited by 44 publications

References 37 publications

Pediatric patch testing in a multi‐ethnic Asian population: A retrospective review

Pediatric patch testing in a multi‐ethnic Asian population: A retrospective review

Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000–2016*

Contact Allergy in Children

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