Pediatric brain tumors in Nigeria: clinical profile, management strategies, and outcome

Uche, Enoch Ogbonnaya; Shokunbi, Temitayo; Malomo, A O; Akang, E. E. U.; Lagunju, Ikeoluwa; Amanor-Boadu, S.D.

doi:10.1007/s00381-013-2105-9

Cited by 41 publications

(47 citation statements)

References 20 publications

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“…The rate of SI associated with these causes of hydrocephalus is relatively high compared to rates with aqueduct stenosis, where 2 cases of SI occurred in 49 (1:25) patients and tumor-associated hydrocephalus with 1 case of SI was found in 24 cases (table 1). We showed in a recent paper that pediatric patients with brain tumor-associated hydrocephalus tend to present significantly earlier than brain tumor patients without hydrocephalus [12]. The most common manifestation of SI in our study was fever, which occurred in 14 (82.4%) patients.…”

Section: Discussionmentioning

confidence: 72%

Determinants and Outcomes of Ventriculoperitoneal Shunt Infections in Enugu, Nigeria

et al. 2013

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Background: To evaluate the determinants and outcomes of shunt infection (SI). Methods: One hundred ninety-eight pediatric hydrocephalic patients treated with a ventriculoperitoneal (VP) shunt between January 2008 and August 2012 were retrospectively studied. Patients with SI were compared to those without SI in terms of the occurrence of risk factors and outcomes. Data was analyzed using Statistical Package for the Social Sciences software (version 15). Results: The age range was 2 weeks to 13 years, with a mean age of 3.1 ± 0.19 years for the SI group versus 2.7 ± 0.2 years for those without SI. One hundred and twelve patients were female and 86 were male. SI was recorded in 17 (8.6%) patients. Postinfective hydrocephalus (n = 6) was the most common cause of hydrocephalus in the SI group. Individuals in the SI group, compared to those without infection, were more likely to be underweight (χ² = 23.4, p < 0.01). The mean interval between VP shunt placement and SI was 1.83 ± 1.25 months. Coagulase-negative Staphylococcus (29.4%) was the most common pathogen. The mortality rate in our series was 21.4% in patients with SI compared to 2.7% in those without SI. Conclusion: Coagulase-negative Staphylococcus is currently the most common cause of SI and underweight children appear have a higher risk.

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Section: Discussionmentioning

confidence: 72%

Determinants and Outcomes of Ventriculoperitoneal Shunt Infections in Enugu, Nigeria

et al. 2013

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“…Likewise, Makino K. et al in a population-based epidemiological study in Japan have shown that among 210 children (younger than 15 years) with primary brain tumor, astrocytoma was the most common pathology (35.7%), with a boy to girl ratio of 1.3 [2]. Compatible results have obtained in India by Jain et al [5] and in Nigeria by Uche et al [13]. However, the epidemiological profile might be somehow different in other regions of the world.…”

Section: Discussionmentioning

confidence: 99%

Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran

et al. 2016

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BackgroundAstrocytomas are the most common primary adult brain tumors.ObjectivesIn this study, we investigated the impact of some potential prognostic factors on survival in patients with low and high grade astrocytomas.Patients and MethodsThis retrospective cohort study was performed on patients with brain astrocytoma who were referred to oncology departments, Omid and Ghaem hospitals, Mashhad University of Medical Sciences (2000 - 2011).Results415 patients with a median age of 43 and a male to female ratio of 252:163 (1.54) were recorded. Grade I to IV astrocytoma were found in 40 (9.6%), 88 (21.2%), 71 (17.1%) and 216 (52%) patients. With a median follow up time of 37 months for low grade and 13 months for high grade astrocytoma, the 5-year survival in grades I to IV was 92.1%, 69.1%, 49.2% and 9.6% respectively. In low grade astrocytomas, patients with grade I tumors, being ambulatory (5-year survival: 88% vs. 60.3%, P < 0.001) and performing optimal surgery (5-year survival 86% vs. 59.3%, P < 0.001) were associated with more favorable survival. In high grade astrocytomas, patients with grade III tumors, age < 50 (5-year survival 29.6% vs. 14.6%, P < 0.001), being ambulatory (5-year survival 39.4% vs. 10.5, P < 0.001), performing optimal surgery (5-year survival 46.1% vs. 4.3%, P < 0.001) and receiving chemotherapy (5-year survival 23.7% vs. 18.7%, P = 0.02) were associated with significantly higher overall survival.ConclusionsPerforming optimal surgery and good performance status were associated with more favorable survival in both low and high grade astrocytomas. In high grade a strocytomas, patients younger than 43 and those who received chemotherapy had better overall survival.

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“…In Nepal, these 4 tumors combined accounted for The theme of delayed presentation was observed both in our study as well as in studies of other LMICs. [21,24] Though the cultural reasons for late presentation are likely complex, there are clear socioeconomic factors that are prohibitive of earlier presentation and diagnosis. Delayed presentation and treatment likely negatively impact the survival of children in LMIC with CNS tumors.…”

Section: Nepal Compared To Other Lmicmentioning

confidence: 99%

“…[2] The ability to perform comparable follow-up in LMIC simply does not exist -evidenced by the limited survival data and absence of long term follow-up data. [20,24] M A N U S C R I P T…”

Section: Limitations Highlight Socioeconomic Realitiesmentioning

confidence: 99%

Pediatric Central Nervous System Tumors in Nepal: Retrospective Analysis and Literature Review of Low- and Middle-Income Countries

et al. 2015

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Pediatric brain tumors in Nigeria: clinical profile, management strategies, and outcome

Abstract: Focal motor signs and elevated intracranial pressure are the salient presenting features of brain tumors in children seen in Nigeria. Those of them with hydrocephalus are likely to present early. The outcome for pediatric brain tumors remains poor.

Cited by 41 publications

References 20 publications

Determinants and Outcomes of Ventriculoperitoneal Shunt Infections in Enugu, Nigeria

Determinants and Outcomes of Ventriculoperitoneal Shunt Infections in Enugu, Nigeria

Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran

Pediatric Central Nervous System Tumors in Nepal: Retrospective Analysis and Literature Review of Low- and Middle-Income Countries

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