Pediatric celiac disease

Zawahir, Shamila; Safta, Anca; Fasano, Alessio

doi:10.1097/mop.0b013e32832f5b9d

Cited by 43 publications

(40 citation statements)

References 29 publications

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“…[1][2][3] CD is caused by an inflammatory T-cell response to the storage proteins in wheat (gliadin), rye (secalin) and barley (hordein), which are collectively called gluten. Large-scale screening studies in the general population have shown a CD prevalence of nearly 0.5-1.0% in both adults and children.…”

Section: Mass Screening Of CD In Young Childrenmentioning

confidence: 99%

Childhood coeliac disease: towards an improved serological mass screening strategy

Esch

Csizmadia

Hoogstraten

et al. 2010

Aliment Pharmacol Ther

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Section: Mass Screening Of CD In Young Childrenmentioning

confidence: 99%

Childhood coeliac disease: towards an improved serological mass screening strategy

Esch

Csizmadia

Hoogstraten

et al. 2010

Aliment Pharmacol Ther

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“…Research suggests that CD is a relatively common diagnosis, with estimates approximating nearly 1 in 100 children living with CD, although many cases remain undiagnosed in part due to the heterogeneity of symptom presentation [45][46][47]. As previously noted, the primary treatment for the disorder is life-long adherence to a gluten-free diet.…”

Section: Celiac Diseasementioning

confidence: 95%

“…As previously noted, the primary treatment for the disorder is life-long adherence to a gluten-free diet. Compliance with such a stringent diet has been shown to be problematic and challenging to many children and adolescents with CD [7,47,48], and may put children and adolescents at an increased risk for the development of eating pathology.…”

Section: Celiac Diseasementioning

confidence: 99%

“…Umbrella term for Crohn's Disease and ulcerative colitis, which are chronic, autoimmune disorders that affect the GI system and causes inflammation, disrupting the absorption of nutrients [3] 10%-15% of those with IBD are diagnosed before of the age of 18 [33] Celiac Disease (CD) Autoimmune condition where an individual has difficulty digesting gluten, and if the individual does, it can cause pain and inflammation in the GI system [6] Approximately 1 in 100 children is living with CD, while many cases may remain undiagnosed [45][46][47] Long-term psychosocial issues often present alongside DRCHCs. For instance, individuals with T1D often experience mood difficulties and anxiety associated with their disorder, which may result in nonadherence [12,13].…”

Section: Drchc Definition Prevalencementioning

confidence: 99%

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Adolescents with Diet-Related Chronic Health Conditions (DRCHCs) and Unique Risk for Development of Eating Pathology

David¹,

Culnan²,

Эрнст³

2017

J Child Adolesc Behav

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Diet-Related Chronic Health Conditions (DRCHCs) are a subset of chronic health illnesses, which presently includes Inflammatory Bowel Disease (IBD), Type 1 Diabetes (T1D), Cystic Fibrosis (CF), and Celiac Disease (CD). Food and diet play integral roles in the management and progression of each condition. The diversity of treatments for DRCHCs encompass therapies that impact diet, weight, and body shape, such as steroids, insulin, and special and/or restrictive diets. Often with efforts to control unwanted side effects of the myriad of treatments, there is poor adherence to prescribed therapies. Given the psychosocial burden of DRCHCs, and the high degree of focus on weight and diet involved in managing each disorder, it is not surprising that those living with DRCHCs may be at risk for developing body image concerns, including poor body image and weight concerns, which may increase the risk for the development of eating pathology. In addition to summarizing current eating pathology risk factors present in DRCHCs, the proposed article builds on previous research by recommending an expansion of the category of DRCHCs to include Type II Diabetes and serious/anaphylactic food allergies, and hypothesizes DRCHC-specific eating pathology risk factors, such as hyper focus on weight, medically-related food restriction, and societal acceptance of thinness despite health issues. The article concludes with clinical recommendations for pediatric medical providers to potentially minimize the negative impact of DRCHC on pediatric patients' medical and psychosocial outcomes.

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“…The vast majority of these symptoms are mainly seen in young children (Zawahir 2009, Lionetti 2011). …”

Section: Clinical Features and Demographicsmentioning

confidence: 99%

Demographics, clinical features and treatment of pediatric celiac disease

Tapsas¹

2015

Linköping University Medical Dissertations

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Celiac disease (CD) is a chronic small intestinal immune-mediated enteropathy triggered by ingestion of gluten-containing food in genetically predisposed subjects. The enteropathy is presented with a wide variety of clinical manifestations, which can occur even outside the gastrointestinal tract. In the majority of cases, the diagnosis of CD is based on a small intestinal biopsy showing mucosal alterations, i.e. intraepithelial lymphocytosis, crypt hyperplasia, and villous atrophy. The treatment, gluten-free diet (GFD), has recently been revised with the addition of gluten-free oats. Oats give a more diversified nutrition and increase the fibre content. The use of oats in CD is though still debated in some reports. A strict life-long adherence to the GFD can be problematic, especially for pediatric CD patients. Sweden reported of one of the highest observed CD prevalences worldwide, i.e. 3%, among 12-year-olds born during what has been described as "the Swedish celiac epidemic", 1984−1996.The aims of this thesis were to elucidate how pediatric CD has changed during a 41-year period in Sweden, i.e. 1973Sweden, i.e. −2013, in terms of clinical presentation, disease severity, incidence, and demographics. We also wanted to adress the compliance to the GFD, the use of oats in the GFD and the safety of oats inclusion in the diet by measuring urinary nitric oxide (NO) metabolites.Filed information provided data about 2856 pediatric patients investigated for suspected CD between 1973 and 2013; of which 1030 patients were diagnosed with CD. After the data analyses the mean age of CD patients was shown to increase after the celiac epidemic period.Currently, CD shows a less severe picture in terms of symptoms and intestinal pathology.Younger children suffer primarily from gastrointestinal symptoms and growth failure, whereas extra-intestinal manifestations are more often displayed among adolescents. viWe also reported an unusually high pediatric CD incidence rate and cumulative incidence, likely the highest reported worldwide. We hypothesised that the introduction of new antibody tests would affect the diagnostic activity and accuracy in performing small intestinal biopsies for CD investigation. However, the outcome of diagnostic activity and accuracy could not clearly be attributed to the use of antibody tests due to changes occurring in parallel during the 41-year study period, e.g. a different pattern of symptoms at presentation and improved knowledge of the disease among parents and health professionals.In a questionnaire-based study our patient group reported a high compliance to the GFD.Long duration of the GFD may, however, influence compliance negatively. Oats have been included to the GFD of our study population in most of the cases without reporting major complications related to their well-being.The urinary measurements of NO metabolites revealed two patient groups, one with high and one with low levels. The two populations did not differ regarding sex, age, compliance to the GFD or oats consumption. Fa...

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Pediatric celiac disease

Cited by 43 publications

References 29 publications

Childhood coeliac disease: towards an improved serological mass screening strategy

Childhood coeliac disease: towards an improved serological mass screening strategy

Adolescents with Diet-Related Chronic Health Conditions (DRCHCs) and Unique Risk for Development of Eating Pathology

Demographics, clinical features and treatment of pediatric celiac disease

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