Pediatric Classification and Epidemiology of Acute Renal Injury

Савенкова, Н. Д.

doi:10.21508/1027-4065-2018-63-5-36-42

Cited by 4 publications

(7 citation statements)

References 35 publications

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“…В исследование включены 30 детей, находившихся на лечении в отделении новорожденных и недоношенных детей ГБУЗ НО «Детская городская клиническая больница № 1» Нижнего Новгорода с признаками острого повреждения почек на основании его диагностических критериев [3,11]. Дети были рождены на сроке гестации от 29 до 36 недель включительно.…”

Section: материа лы и методыunclassified

“…При оценке степени тяжести острого повреждения почек с использованием pRIFLE по A. Аkcan-Arikan et al [7] было выявлено снижение СКФ в 1-й группе детей на 44 % относительно возрастного норматива [3]. Во 2-й группе отмечалось снижение СКФ на 32,8 % по сравнению с возрастной нормой [3]. Полученные данные указывают на легкую степень тяжести острого повреждения почек в обеих группах пациентов, классифицируемую как стадию риска («Risk»).…”

Section: результаты и их обс у ж дениеunclassified

“…Поражению почек в неонатальном периоде также способствует их морфофункциональная незрелость, в ряде случаев усугубляемая развитием внутриутробной инфекции и других патологических процессов [2,3]. Кроме того, интенсивная терапия, включающая в себя респираторную поддержку, парентеральное питание, массивную медикаментозную терапию, приводит к повышению нагрузки на незрелые почки недоношенного ребенка [11].…”

Section: Introductionunclassified

“…Результаты эпидемиологических исследований демонстрируют рост частоты острого повреждения почек с высоким риском летального исхода у недоношенных новорожденных, имеющих низкий гестационный возраст и низкую, очень низкую, экстремально низкую массу тела при рождении [1,3,7,8]. Приведенные данные указывают на необходимость раннего выявления данного состояния для своевременной коррекции проводимой терапии.…”

Section: Introductionunclassified

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Renal function in premature infants in the neonatal period

et al. 2020

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The aim of the investigation was to assess the functional state of the kidneys of preterm infants of various gestational ages with signs of acute kidney injury. Materials and Methods. The study included 30 preterm infants born at 29 to 36 weeks gestation with signs of acute kidney injury. Patients were divided into two groups: group I included children with low body weight, born at 3236 weeks of gestation; group II with very low birth weight, born at 2931 weeks of gestation. In the study of kidney function, the main markers were analyzed serum creatinine, urea, diuresis level, glomerular filtration rate (GFR) at the third week of life, as well as at discharge from the hospital when reaching the postconceptual gestational age of 36.0 [35.0; 39.0] weeks. Severity was assessed in both groups of patients. Results. In both groups of children, a slight degree of severity was recorded, the risk stage (Risk) according to the pRIFLE classification criteria (2007). The evaluation of the biochemical blood test did not show a statistically significant difference in creatinine, urea, GFR, and the rate of diuresis between groups of children with low body weight and very low birth weight. In both groups of patients, creatinine and urea levels in the third week of life exceeded the age standards. By the time the postconceptual gestational age was reached at 36.0 [35.0; 39.0] weeks, there was a statistically significant decrease in the level of these indicators in patients of both groups. In addition, it was found that premature children are at risk for the formation of hyperoxaluria (53% in the structure of crystalluria). Conclusion. Timely diagnosis of acute kidney injury in premature newborns will allow adequate therapy to prevent the progression and further formation of terminal renal failure. It is important to determine the level of excretion of oxalates in the urine to prevent the development of urolithiasis.

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Section: материа лы и методыunclassified

Section: результаты и их обс у ж дениеunclassified

Section: Introductionunclassified

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Renal function in premature infants in the neonatal period

et al. 2020

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“…Следует подчеркнуть, что в проведенном нами анализе отечественной и зарубежной литературы [14], в опубликованных результатах научных исследований у новорожденных, монографиях чаще представлены классификации AKI Network ( 2007) [4], J.G. Jetton, D.J.…”

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Acute kidney injury in the newborn infant: classification, causes and epidemiology

Ivanov

Савенкова

2019

Nefrologiâ (St.-Peterbg.)

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In the article are presented classifications, causes and epidemiology of acute kidney injury (AKI) in newborns, unsolved problems. Neonatal AKI classifications proposed by Acute Kidney Injury Network (2007), JG Jetton, DJ Askenazi (2012), modifications from NKC, KDIGO, and AWAKEN (2016), AKI Workshop (2017) are discussed. The results of the international assessment Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN), JG Jetton et al (2016, 2017) are discussed. Of the 2022 babies, 605 (30 %) had the status of AKI: in 48 % of the 273 preterm neonates with gestatoinal age 22-29 weeks; 18 % of 916 preterm neonates with gestatoinal age 29-36 weeks; in 37 % of 833 neonates with gestatoinal age after 36 weeks. The risk factors for the development of early AKI in preterm infants include low gestational age and very low birth weight. According to international epidemiological studies, the development of AKI in premature newborns is the main and independent risk factor for mortality and the formation of chronic kidney disease. The absence of multicenter epidemiological studies of acute kidney damage in newborns in our country is still an unsolved problem. The solution of the problem facing the national neonatology should be aimed at ensuring a unified approach to the classifications of acute kidney damage, on studying epidemiology, features of development, course, and outcome of acute kidney damage of various etiologies, on developing algorithms for prevention, diagnosis and treatment in term and preterm infants.

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Prenatal renal oligohydramnion and renal function in newborns and infants with cystic kidney diseases

Андреева

Савенкова

2021

Nefrologiâ (St.-Peterbg.)

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THE AIM:to describe the causes, pathogenesis, clinical course and outcome of Potter sequence in children with cystic kidney disease. PATIENTS AND METHODS:the follow-up study of 23 newborns with cystic kidney disease was studied, in which renal oligohydramnios (ROH) was confirmed prenatally by ultrasound (US). RESULTS:Of the 155 children with autosomal dominant polycystic kidney disease (ADPKD), 8 (5,2 %) prenatal after 30 weeks of gestation established ROH, at 26-32 weeks of gestation – cyst in the kidney by US, in 2 of them ROH confirmed simultaneously with the detection of cysts in kidneys of a fetus, 6 – late detection of kidney cysts. Of the 8 newborns with a very early onset ADPKD, prenatal developed in ROH conditions, in 2 (25 %) in the neonatal period diagnosed the Potter phenotype. Of the 20 children with autosomal recessive polycystic kidney disease (ARPKD), 12 (60 %) prenatally revealed ROH after 18 weeks of gestation prenatally, of these, 8 (67 %) in the neonatal period diagnosed the Potter phenotype. Of the 12 newborns with ARPKD, that developed in ROH conditions, in 5 (42 %) kidney cysts were detected prenatally by US at 32-37 weeks of gestation, in 7 (58 %) in the neonatal period. ROH and the Potter phenotype are more common with ARPKD in the fetus than with ADPKD. Among children with ARPKD and ADPKD undergoing ROH, no statistically significant differences in the frequency of deaths in the neonatal and infancy. The characteristics of course and outcome of the Potter sequence in the neonatal and infant periods in a boy with deletion of 12p and cystic kidney disease are described. ROH in 2 children with cystic kidneys and coloboma of the optic nerve disc did not lead to the formation of the Potter phenotype. In 15 children with multicystic kidney prenatal US showed no ROH. CONCLUSION: the results of a follow-up study of children after ROH and the course of the Potter sequence for different cystic kidney disease in children are presented.

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Pediatric Classification and Epidemiology of Acute Renal Injury

Cited by 4 publications

References 35 publications

Renal function in premature infants in the neonatal period

Renal function in premature infants in the neonatal period

Acute kidney injury in the newborn infant: classification, causes and epidemiology

Prenatal renal oligohydramnion and renal function in newborns and infants with cystic kidney diseases

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